Edarbyclor
Edarbyclor (azilsartan / chlorthalidone) is used to treat high blood pressure in adults. It's a combination medication that contains an angiotensin II receptor blocker (ARB), azilsartan, and a thiazide diuretic, chlorthalidone, both of which are first-choice blood pressure medications. Edarbyclor might be a good option for people who need many medications to manage blood pressure. The tablets are taken by mouth once per day. This medication has few side effects, which can include dizziness. It's brand name only, though; there's no lower-cost generic yet.
What is Edarbyclor (azilsartan / chlorthalidone)?
What is Edarbyclor (azilsartan / chlorthalidone) used for?
- High blood pressure in adults
How Edarbyclor (azilsartan / chlorthalidone) works
Edarbyclor (azilsartan / chlorthalidone) is a combination of two blood pressure medications.
- Azilsartan is an angiotensin II receptor blocker (ARB). It works by blocking angiotensin II, a hormone that's naturally found in the body. This helps relax your blood vessels so blood can flow through more easily.
- Chlorthalidone is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium). This lessen the amount of fluid that flows through your blood vessels, which helps lower blood pressure.
Drug facts
Side effects of Edarbyclor (azilsartan / chlorthalidone)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dizziness (9%)
- Fatigue (2%)
Less Common Side Effects
- Low blood pressure
- Feeling faint
Edarbyclor (azilsartan / chlorthalidone) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: trouble breathing; rash; swelling of the face, arms or legs, lips, tongue, or throat
- Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
- Serious kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain
The following Edarbyclor (azilsartan / chlorthalidone) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Blurred vision
confusion
convulsions
decreased urine
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
increased thirst
irregular heartbeat
loss of appetite
muscle pain or cramps
nausea or vomiting
numbness or tingling in the hands, feet, or lips
shortness of breath
sweating
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Dizziness
Incidence not known
Headache
loss of appetite
rash
stomach cramps
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Edarbyclor (azilsartan / chlorthalidone)
Pros
- Has two first-choice blood pressure medications within a single pill
- Taken by mouth once per day
- Can take together with other blood pressure medications, if needed
Cons
- Available as a brand-name medication only
- Might make you urinate more often
- Not safe to take while pregnant or breastfeeding
- Can't change the dose of each medication in Edarbyclor
Pharmacist tips for Edarbyclor (azilsartan / chlorthalidone)
- Take Edarbyclor (azilsartan / chlorthalidone) with or without food at any time of day.
- It's recommended that you check your blood pressure at home, keep a record of your readings, and share this log with your prescriber at each follow-up visit. This helps your prescriber understand how well Edarbyclor (azilsartan / chlorthalidone) is working for you and they can recommend any dose changes if needed.
- Mark your calendar with your appointments to see your prescriber and to get any blood work done as you take Edarbyclor (azilsartan / chlorthalidone). Your care team will order tests during treatment to check your electrolyte levels and kidney function. These lab results help make sure the medication is safe for you to take.
- Take Edarbyclor (azilsartan / chlorthalidone) exactly as prescribed. Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Otherwise, your blood pressure might rise quickly. Your prescriber might lower your dose slowly over time before you can completely stop taking. This prevents your blood pressure from changing too quickly while you're making these adjustments.
- Edarbyclor (azilsartan / chlorthalidone) can cause dizziness, especially when you first start taking it or when your dose goes up. These symptoms should lessen as you continue taking the medication. Stand up slowly from sitting or lying positions to prevent falls. Let your prescriber know if you feel faint, lightheaded, or confused.
- Edarbyclor (azilsartan / chlorthalidone) might make your skin be more sensitive to sunlight, so you might sunburn more easily. It's a good idea to apply sunscreen and wear protective clothing when you go out.
- It's best to avoid or limit how much alcohol you drink while you're taking Edarbyclor (azilsartan / chlorthalidone). Drinking regularly, especially in high amounts, can make your blood pressure get higher. Alcohol might also raise your risk for side effects like feeling dizzy or lightheaded.
- Tell your care team about the medications you're taking or planning to take. They can check that your medications are safe to take together. This is because Edarbyclor (azilsartan / chlorthalidone) can interact with many medications, including nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil).
- It's important to eat nutritious foods that are low in salt while you're taking Edarbyclor (azilsartan / chlorthalidone). Be sure to also add low-fat milk or yogurt, whole grains, and vegetables into your diet. Ask your care team for more information about different foods to include in your diet to help lower your blood pressure.
- Speak with your prescriber right away if you're pregnant or thinking of getting pregnant and you're taking Edarbyclor (azilsartan / chlorthalidone). This medication can harm an unborn baby if it's taken while you're pregnant. Your prescriber will switch you to a different medication that's safe during pregnancy.
- It's not recommended to breastfeed while you're taking Edarbyclor (azilsartan / chlorthalidone). It's not known whether this medication is safe for you or your baby while breastfeeding. To be safe, discuss with your prescriber about possibly switching to a different blood pressure medication.
Common questions about Edarbyclor
Edarbyclor contains two first-choice medications that work well to lower blood pressure. In clinical studies, the systolic blood pressure (the "top number") dropped by an average of about 40 mmHg for people who took azilsartan and chlorthalidone together for 2 months. Note that everyone can have a different experience taking Edarbyclor. Your prescriber will keep track of your progress while you're taking this medication and adjust your treatment plan when needed.
You might have a change in your blood pressure within hours of taking Edarbyclor. But it can take about 1 to 2 weeks to see the full blood pressure-lowering effect of this medication. Note that it can take a few weeks before your prescriber finds a stable dose that works best for you since you might need dose adjustments depending on your blood pressure readings. Your prescriber might add another blood pressure medication on top of Edarbyclor if your blood pressure is still too high. Make sure to be patient, continue to take Edarbyclor, and follow up with your prescriber regularly.
Since Edarbyclor is made up of two medications, each medication stays in your system for a different amount of time. It takes about 2.5 days for most of azilsartan and about 9 days for most of chlorthalidone to leave your body after a single dose. This time frame is estimated based on the half-life of azilsartan and chlorthalidone. The medication can stay in the system for a longer period of time for people with kidney problems because Edarbyclor is removed from the body by the kidneys. Talk with your healthcare team if you have any specific concerns related to how long this medication stays in your body.
Don't cut Edarbyclor tablets in half unless your healthcare team says it's safe to do so. Edarbyclor is a combination medication, and the tablets don't have a score line (an indented line in the middle of the tablet to cut). It's generally not recommended to cut pills that are combination medications because the two resulting halves might not contain the same amount of the active ingredients. Also, it's difficult to cut a non-scored tablet evenly (even if you're using a pill splitter), which can cause you to take the wrong dose. Speak with your prescriber if you're having trouble swallowing Edarbyclor tablets whole.
No, Edarbyclor isn't a beta blocker. Edarbyclor is a combination of two medications: azilsartan, which is an angiotensin II receptor blocker (ARB), and chlorthalidone, which is a thiazide diuretic. Beta blockers, ARBs, and diuretics all work to lower blood pressure, but they do so in different ways. Ask your healthcare team if you have more questions on the different types of blood pressure medications.
People who took Edarbyclor during clinical studies didn't say that they had hair loss as a side effect of the medication. Contact a healthcare professional if you experience hair loss while you're taking Edarbyclor. They can help you figure out possible causes for the hair loss.
Weight gain isn't a typical side effect of Edarbyclor. Let your primary care provider or cardiologist know if you experience unusual or unexpected weight gain while you're taking this medication.
No, Edarbyclor is currently only available as a brand-name medication.
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Risks and warnings for Edarbyclor (azilsartan / chlorthalidone)
Edarbyclor (azilsartan / chlorthalidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Not safe during pregnancy
Edarbyclor (azilsartan / chlorthalidone) can cause severe and sometimes life-threatening harm to an unborn baby if it's taken during pregnancy. For this reason, you shouldn't take Edarbyclor (azilsartan / chlorthalidone) if you're pregnant. Stop taking Edarbyclor (azilsartan / chlorthalidone) and let your prescriber know right away if you become pregnant while you're taking this medication. They'll recommend safer options to treat your blood pressure.
Low blood pressure
- Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking higher doses of diuretic medications | Dialysis
Sometimes, taking Edarbyclor (azilsartan / chlorthalidone) can cause your blood pressure to drop too much. This can cause you to feel dizzy, tired, or lightheaded. Having very low blood pressure while you're taking this medication is more likely if you're dehydrated or if you're taking a high dose of a diuretic.
Make sure to stay well-hydrated. Sit down slowly while holding onto something and let your care team know if your blood pressure drops too much and you feel dizzy. Get medical help right away if you fall and hit your head.
Changes in electrolyte levels
Edarbyclor (azilsartan / chlorthalidone) can affect the level of certain electrolytes in your body like sodium, potassium, and magnesium. Your prescriber might regularly order blood tests to make sure your electrolytes are at a safe level. Let your care team know if you have a fast heartbeat, weakness, low energy, muscle pain or cramps, less urination than usual, nausea, or vomiting. These can be signs of electrolyte changes in your body.
Kidney damage and waste buildup due to kidney problems
- Risk factors: Severe congestive heart failure | Kidney problems | Not enough fluid in your body | Taking other medications that can cause kidney damage
Sometimes, Edarbyclor (azilsartan / chlorthalidone) can cause your kidneys to not work as well. The risk is higher for people who have certain types of kidney problems or severe congestive heart failure. Your prescriber might order lab tests every so often to make sure your kidneys are healthy and working properly. Tell your care team if you're having problems urinating, as this could be a sign that your kidneys aren't working as well.
Typically, the kidneys are responsible for getting rid of certain waste products from the body. But when the kidneys don't work as well (like in people with kidney problems), taking Edarbyclor (azilsartan / chlorthalidone) can cause these waste products to build up in the body. Contact your prescriber right away if you have symptoms such as trouble making urine, swelling in your legs, weakness, and confusion.
Higher risk for gout attacks
- Risk factors: History of gout
Edarbyclor (azilsartan / chlorthalidone) can cause your body to hang onto uric acid, which can raise your risk of gouty attacks. Let your prescriber know if you have a history of gout.
Edarbyclor (azilsartan / chlorthalidone) dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 40mg/12.5mg | 30 tablets | $261.48 | $8.72 |
| 40mg/25mg | 30 tablets | $260.28 | $8.68 |
Typical dosage for Edarbyclor (azilsartan / chlorthalidone)
The typical starting dose is 40 mg/12.5 mg (azilsartan/chlorthalidone) by mouth once daily. The maximum dose is 40 mg/25 mg (azilsartan/chlorthalidone) per day.
Your prescriber will adjust your dose based on how well Edarbyclor (azilsartan / chlorthalidone) is working to control your blood pressure and whether you're having side effects.
Interactions between Edarbyclor (azilsartan / chlorthalidone) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Acetyldigoxin
- Amtolmetin Guacil
- Arsenic Trioxide
- Aspirin
- Benazepril
- Bepridil
- Bromfenac
- Bufexamac
- Captopril
- Celecoxib
- Ceritinib
- Choline Salicylate
- Clonixin
- Deslanoside
- Desmopressin
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Digitalis
- Digitoxin
- Digoxin
- Dipyrone
- Dofetilide
- Droperidol
- Droxicam
- Enalapril
- Enalaprilat
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Flecainide
- Floctafenine
- Fluconazole
- Flufenamic Acid
- Flurbiprofen
- Fosinopril
- Ibuprofen
- Indomethacin
- Ketanserin
- Ketoprofen
- Ketorolac
- Levomethadyl
- Lisinopril
- Lithium
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Metildigoxin
- Moexipril
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Perindopril
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Potassium Phosphate
- Proglumetacin
- Propyphenazone
- Proquazone
- Quinapril
- Ramipril
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sodium Salicylate
- Sotalol
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Trandolapril
- Trimethoprim
- Valdecoxib
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Bromfenac
- Bufexamac
- Celecoxib
- Choline Salicylate
- Clonixin
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Gossypol
- Ibuprofen
- Indomethacin
- Ketoprofen
- Ketorolac
- Licorice
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Proglumetacin
- Propionic Acid
- Propyphenazone
- Proquazone
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sodium Salicylate
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Valdecoxib
- Warfarin
How much does Edarbyclor (azilsartan / chlorthalidone) cost?
$260.28
Edarbyclor (azilsartan / chlorthalidone) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Edarbyclor (azilsartan / chlorthalidone) will not be safe for you to take.
- Taking it along with aliskiren (Tekturna) in people with diabetes
- Not urinating at all
What are alternatives to Edarbyclor (azilsartan / chlorthalidone)?
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