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methylphenidate

Generic Daytrana
Used for ADHD
Used for ADHD

Daytrana, also known by its generic name methylphenidate, is a stimulant medication. It's used to treat children ages 6 to 17 years with ADHD (attention deficit-hyperactivity disorder). Daytrana is a patch that's applied on the skin once per day in the hip area. The patch is also available as a lower-cost generic. Treatment typically starts with a low dosage, and then the dosage is adjusted depending on how well the medication works to manage ADHD. Side effects include low appetite, headache, and nausea.

Last reviewed on June 26, 2024
Daytrana (methylphenidate) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Daytrana (methylphenidate)?

What is Daytrana (methylphenidate) used for?

  • ADHD (attention deficit-hyperactivity disorder) in children ages 6 to 17 years

How Daytrana (methylphenidate) works

Daytrana (methylphenidate) is a stimulant medication. It's not exactly known how Daytrana (methylphenidate) helps to improve attention and focus. But it's thought to work by raising the levels of chemicals in your brain called norepinephrine, dopamine, and serotonin.

Drug Facts

Common BrandsDaytrana
Drug ClassStimulant
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Daytrana (methylphenidate) essentials

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What are the risks and warnings for Daytrana (methylphenidate)?

Daytrana (methylphenidate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Risk for misuse and addiction

  • Risk factors: History of substance or alcohol use disorder | Taking more Daytrana (methylphenidate) than prescribed

    Daytrana (methylphenidate) has a risk for misuse and addiction. Misuse is when a medication is used differently than how it's prescribed. Misusing Daytrana (methylphenidate) can raise your risk for serious side effects such as fast heart rate, high blood pressure, aggressive behavior, and even thoughts of hurting yourself. In addition, misusing Daytrana (methylphenidate) can sometimes lead to addiction. Take Daytrana (methylphenidate) exactly as prescribed. Speak with your child's prescriber if you're concerned about this risk.

    Because of the risk for misuse and addiction, store Daytrana (methylphenidate) in a safe place out of reach from children, pets, and visitors. Don't give the medication to anyone else. If your child no longer needs Daytrana (methylphenidate), dispose of the patches through a take-back program. You can also remove the Daytrana (methylphenidate) patch from the pouch, fold it in half with the sticky sides touching each other, and flush it down the toilet. This lowers the risk for accidental overdose and helps prevent medication misuse.

    risk-warning

    Risk for dependence and withdrawal

    • Risk factors: Suddenly stopping Daytrana (methylphenidate)

      Taking Daytrana (methylphenidate) for a long period of time can put people at risk for dependence. This means that over time, people can become physically dependent on Daytrana (methylphenidate) to function normally. Physical dependence is usually related to having withdrawal symptoms, like irritability, nightmares, and sleep problems, if people take the medication for a long time and then suddenly stop or suddenly lower the dose. Make sure to take Daytrana (methylphenidate) exactly as prescribed. Don't change the dose or how often you take without talking to the prescriber first.

      risk-warning

      Risks for people with serious heart problems

      • Risk factors: History of heart problems

        There have been reports of sudden death and heart attack in people with a heart condition who took stimulant medications like Daytrana (methylphenidate) at usual doses. This medication can also raise blood pressure and heart rate.

        Tell your child's prescriber if your child has a history of heart problems before treatment starts to make sure Daytrana (methylphenidate) is safe to take. Your child's prescriber will check for heart problems before starting treatment. Your child might not be able to take Daytrana (methylphenidate) if they have serious heart problems.

        Let your child's prescriber or primary care provider know if your child experiences unexplained fainting, chest pain with physical activity, or irregular heartbeat during treatment with Daytrana (methylphenidate). The care team can check your child's heart to make sure everything is okay.

        risk-warning

        Aggressive behavior and psychosis

        • Risk factors: History of psychotic episodes, bipolar disorder, or other mental health or mood-related conditions

          Some people who've taken a stimulant like Daytrana (methylphenidate) can have mental health problems, such as hallucinations (seeing things that aren't really there), aggressive behavior, unclear thinking, and mania. This medication can worsen mood-related problems that your child already has, but these changes in behavior can also happen even if they haven't had these problems before. Talk to your child's prescriber right away if your child develops these mood or behavior changes during treatment with Daytrana (methylphenidate). Your child might have to stop the medication.

          risk-warning

          Slowed growth in children

          In studies, stimulants like Daytrana (methylphenidate) slowed the growth rate (both in height and weight) and caused weight loss in children. Let your child's pediatrician or primary care provider know that your child is taking Daytrana (methylphenidate). They'll need to check your child's growth progress closely. Your child might need to briefly stop or completely stop taking Daytrana (methylphenidate) if there's a possibility of any slowed growth that's happened. Talk to your child's primary care provider if you have any concerns.

          risk-warning

          Seizures

          • Risk factors: History of seizures | High risk of seizures

            Although rare, taking stimulants like Daytrana (methylphenidate) might raise the likelihood of having a seizure more easily, especially if your child had seizures before. Get medical help right away if your child has a seizure. Your child will probably have to stop taking Daytrana (methylphenidate) if a seizure happens during treatment.

            risk-warning

            Blood circulation problems (such as Raynaud's phenomenon)

            Daytrana (methylphenidate) might be linked to poor blood circulation problems, such as Raynaud's phenomenon. People with Raynaud's phenomenon can have episodes of poor blood flow in the fingers and toes, which can cause the skin to turn pale and to feel cold, numb, or painful. Symptoms are usually mild. But rarely, it can cause sores or ulcers in more serious cases. Let your child's prescriber know if your child complains about instances of numbness or pain in the fingers or toes. Your child's prescriber might need to lower the Daytrana (methylphenidate) dose or consider a different medication.

            risk-warning

            Risk for high pressure in the eye and for glaucoma

            Although rare, some people who took methylphenidate medications like Daytrana (methylphenidate) reported developing higher pressure in the eyes, which can lead to glaucoma. Make sure your child visits their optometrist for regular eye exams. Speak with the optometrist if your child reports any changes in vision during treatment.

            risk-warning

            Drug interactions

            Daytrana (methylphenidate) can interact with many medications. For example, Daytrana (methylphenidate) can counteract (work against) the effects of many blood pressure medications. This means that blood pressure medications might not work as well if they're taken with Daytrana (methylphenidate). Additionally, taking Daytrana (methylphenidate) with monoamine oxidase inhibitors (MAOIs) can raise the risk of having severely high blood pressure, so it's best to avoid this combination. Discuss with your child's care team about all the medications they take (including over-the-counter medications and supplements) before and during treatment with Daytrana (methylphenidate).

            basics-icon

            What are the side effects of Daytrana (methylphenidate)?

            The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

            Common Side Effects

            • Low appetite (26%)
            • Headache (up to 15%)
            • Trouble sleeping (up to 13%)
            • Nausea (up to 12%)
            • Feeling irritable (up to 11%)
            • Vomiting (up to 10%)
            • Weight loss (up to 9%)
            • Stomach pain (up to 7%)
            • Dizziness (up to 6%)

            Other Side Effects

            • Blurry vision
            • Fatigue
            • Nervousness
            • Application site reaction (e.g., redness, itchy)
            • Rash

            Serious Side Effects

            Contact your healthcare provider immediately if you experience any of the following.
            • Allergic reactions: rash; hives; swelling or blisters where the patch is applied; difficulty breathing; swelling of face, lips, tongue, or throat
            • Heart problems: heart attack, fast heart rate, high blood pressure
            • Brain-related problems: seizures, stroke
            • Mental health-related problems: manic episodes, changes in thoughts or behavior, hallucinations
            • Prolonged and painful erection (lasting several hours)
            • Accidentally take too much medication (overdose): restlessness, quick breathing, fast heartbeat, irritability, aggression, fever

            Source: DailyMed

            The following side effects have also been reported

            Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

            Check with your doctor immediately if any of the following side effects occur:

            More common

            Aggressive and violent behavior

            arm, back, or jaw pain

            black, tarry stools

            blistering, peeling, or loosening of the skin

            blood in the urine

            bloody nose

            chest pain or discomfort

            chest tightness or heaviness

            chills

            cold

            confusion

            cough or hoarseness

            cracks in the skin

            crying

            depersonalization

            diarrhea

            dizziness

            dysphoria

            euphoria

            fainting

            fast, pounding, or irregular heartbeat or pulse

            fever

            flu-like symptoms

            heavier menstrual periods

            joint or muscle pain

            loss of heat from the body

            nausea

            nervousness

            paranoia

            pinpoint red spots on the skin

            quick to react or overreact emotionally

            rapidly changing moods

            red, irritated eyes

            red, swollen skin

            scaly skin

            seeing, hearing, or feeling things that are not there

            severe or sudden headache

            skin rash or itching

            sore throat

            sores, ulcers, or white spots in the mouth or on the lips

            sudden loss of coordination

            sudden slurring of speech

            sweating

            twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

            unusual bleeding or bruising

            unusual tiredness or weakness

            Rare

            Convulsions

            difficulty with breathing

            high fever

            increased sweating

            loss of bladder control

            severe muscle stiffness

            tiredness

            uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

            unusually pale skin

            Incidence not known

            Blistering, burning, crusting, dryness, or flaking of the skin

            chest pain

            difficulty with swallowing

            hives, itching, scaling, severe redness, soreness, or swelling of the skin

            large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

            painful or difficult urination

            pale skin

            paleness or cold feeling in the fingertips and toes

            puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

            swollen glands

            tingling or pain in the fingers or toes when exposed to cold

            troubled breathing with exertion

            Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

            More common

            Abdominal or stomach pain

            decreased weight

            difficulty with moving

            drowsiness

            headache

            loss of appetite

            muscle pain or stiffness

            redness of the skin

            trouble sleeping

            vomiting

            welts

            Less common

            Decreased appetite

            stuffy or runny nose

            weight loss

            Incidence not known

            Bigger, dilated, or enlarged pupils (black part of the eye)

            bleeding, bruising, burning, itching, redness, skin rash, swelling, or soreness at the application site

            blurred or loss of vision

            disturbed color perception

            double vision

            hair loss

            halos around lights

            increased sensitivity of the eyes to light

            night blindness

            overbright appearance of lights

            thinning of the hair

            tunnel vision

            Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

            Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

            pros-and-cons

            Pros and cons of Daytrana (methylphenidate)

            thumbs-up

            Pros

            Patch allows for convenient once-a-day dosing

            Available in different dosage strengths

            Provides long-lasting symptom control for up to 12 hours

            Good option for children who don't want to take pills

            thumbs-down

            Cons

            Not approved for children younger than 6 years of age or adults

            Might permanently lighten the color of your skin and irritate the skin

            Dose needs to be adjusted slowly to avoid side effects and withdrawal symptoms

            Has a risk for misuse and dependence, so it's a controlled substance

            pharmacist-tips

            Pharmacist tips for Daytrana (methylphenidate)

            pharmacist
            • Review the instructions for use for the Daytrana (methylphenidate) patch. Ask your prescriber or pharmacist if you have any questions about how to apply or remove it.

              • Apply the Daytrana (methylphenidate) patch to the hip area 2 hours before you need the medication's effects to start. Wear the patch for up to 9 hours. Applying the patch later in the day or keeping the patch on for longer than 9 hours can raise the risk for side effects, like trouble falling asleep at night.

                • How to apply the Daytrana (methylphenidate) patch: Put the sticky side of the patch to clean, dry, and cool skin on the hip. Firmly press down on the patch and make sure the edges are smoothed down. Alternate areas on the hip where you place the patch each day to prevent skin irritation.

                  • How to remove and throw away the Daytrana (methylphenidate) patch: Slowly peel the patch off. Fold it in half so that the sticky sides are pressed together. Then, flush the patch down the toilet.

                    • Don't cut the Daytrana (methylphenidate) patch. Also, don't get the patch exposed to any direct heat (e.g., heaters, electric blankets). And don't cover the patch with bandages or tape. In all of these situations, extra medication can get released from the patch and raise the risk for serious side effects or life-threatening overdose.

                      • Don't apply lotions, creams, and oils on the skin where you're going to apply Daytrana (methylphenidate). They can make the patch stick less well. Also be aware that bathing, swimming, and showering can make the patch stick less well. Don't try to reapply the patch in any way if it starts to fall off. Take the patch off and place a new one to a different area on the hip.

                        • There might be skin redness, small bumps on the skin, or other skin irritation where you applied the Daytrana (methylphenidate) patch. Contact the prescriber right away if there's any swelling or blistering. These might signs of a more serious problem, like an allergic reaction.

                          • Sometimes, Daytrana (methylphenidate) can make the color of the skin under or near where the patch is placed lighter. This can be permanent. The risk is higher for children with vitiligo. Call the prescriber right away if you notice lighter areas of skin.

                            • Stimulants like Daytrana (methylphenidate) tend to lower appetite, which can potentially lead to weight loss. Make sure your child follows a nutritious and balanced diet. Let the prescriber know if your child seems to have lost their appetite or have had concerning weight changes during treatment.

                              • If your child can drive, your child should avoid driving during the first few days after starting treatment with Daytrana (methylphenidate) and after dose changes until they know how the medication affects them. This medication might cause dizziness and blurry vision, which can affect how well they're able to drive safely.

                                • Daytrana (methylphenidate) might worsen tics and Tourette syndrome. Talk to a healthcare professional if your child has these problems so they can see whether this medication is right for them.

                                  • Take Daytrana (methylphenidate) exactly as prescribed. Don't change the dose or stop taking the medication without talking to the prescriber first. Doing so can lead to bothersome withdrawal symptoms, such as irritability, tiredness, changes in sleep patterns, and depression.

                                    faqs

                                    Frequently asked questions about Daytrana (methylphenidate)

                                    Is the Daytrana (methylphenidate) patch still available?
                                    Yes. Both the Daytrana brand-name patches and generic methylphenidate patches are still available on the market.
                                    Is there a generic for Daytrana (methylphenidate)?
                                    Yes. The Daytrana (methylphenidate) patch is available as a lower-cost generic.
                                    How long does it take for Daytrana (methylphenidate) to kick in?
                                    It takes about 2 hours for the effects of Daytrana (methylphenidate) to kick in. This is why you should apply the patch to the skin about 2 hours before the time you need the medication's effect to start, such as before school.
                                    How long does Daytrana (methylphenidate) last?
                                    When you wear a Daytrana (methylphenidate) patch for 9 hours, the effects of the medication can last for up to 12 hours. Make sure to take off the Daytrana (methylphenidate) patch at the 9-hour mark. Keeping the patch on for too long raises the risk for side effects like trouble falling asleep at night.
                                    Can adults use Daytrana (methylphenidate) patch?
                                    Daytrana (methylphenidate) is FDA-approved for children ages 6 to 17 years old only. It's not recommended for adults to use Daytrana (methylphenidate) patches because this hasn't been studied, so it's not known how well the patches will work for adults. Additionally, studies show that methylphenidate products might not work as well as amphetamine medications like Adderall for adults with ADHD. Speak with your prescriber about your options if you're looking for an ADHD medication that's available as patches for adults, such as Xelstrym (dextroamphetamine).
                                    Can Daytrana (methylphenidate) patch be cut in half?
                                    No, don't cut Daytrana (methylphenidate) patches in half. Cutting the patch can damage it and make too much medication get released from the patch too quickly. This can raise the risk of having a life-threatening overdose. Contact the prescriber if the Daytrana (methylphenidate) patch is too big for your or your child's liking. Also speak with the prescriber if you're concerned that the dose for your child's Daytrana (methylphenidate) patch is too high. The prescriber can discuss about available options.
                                    Where do I apply Daytrana (methylphenidate) patch?
                                    Apply the Daytrana (methylphenidate) patch onto the skin of your child's hip. After applying the patch, press it down firmly so that the whole patch, including the edges, sticks to the skin well. Make sure to apply the Daytrana (methylphenidate) patch to clean, dry, and cool skin. Don't put the patch over skin that has powder, lotion, or oil on it. Choose a different area on the hip to apply the Daytrana (methylphenidate) patch to each day to lower the risk of skin irritation.
                                    What's the difference between Daytrana and Adderall?
                                    The only similarity between Daytrana and Adderall is that they're both types of stimulants that can be used to treat ADHD. The active ingredient in Daytrana is methylphenidate. And for Adderall, it's a mixture of dextroamphetamine and amphetamine salts. Daytrana is a patch that's applied to the skin once per day, whereas Adderall is a tablet that's taken by mouth once or twice per day. Studies show that amphetamine products (like Adderall) are generally preferred for adults, whereas methylphenidate products (like Daytrana) are preferred for children and adolescents. Ask your psychiatrist or primary care provider if you have more questions about comparing between Daytrana and Adderall.
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                                    dosage

                                    Daytrana (methylphenidate) dosage forms

                                    The average cost for 1 package of 30 patches of 10mg of Daytrana (methylphenidate) is $191.51 with a free GoodRx coupon. This is 63.53% off the average retail price of $525.14.
                                    package
                                    Package
                                    DosageQuantityPrice as low asPrice per unit
                                    30 patches of 10mg1 package$191.51$191.51
                                    30 patches of 15mg1 package$194.33$194.33
                                    30 patches of 20mg1 package$191.51$191.51
                                    30 patches of 30mg1 package$194.33$194.33
                                    patch
                                    Patch
                                    DosageQuantityPrice as low asPrice per unit
                                    10mg30 patches$183.06$6.10
                                    15mg4 patches$27.56$6.89
                                    20mg4 patches$27.55$6.89
                                    30mg4 patches$27.56$6.89

                                    Typical dosing for Daytrana (methylphenidate)

                                    Daytrana (methylphenidate) comes as a patch that's applied to the hip area 2 hours before you need the medication's effects to kick in. Then, the patch is removed 9 hours after putting it on.

                                    The typical starting dose is a 10 mg patch applied to the skin once daily for at least a week. Your child's prescriber will slowly raise the dose, no sooner than once per week, based on how well the medication is working and whether there are bothersome side effects. The maximum dose is a 30 mg patch once per day.

                                    interactions

                                    Interactions between Daytrana (methylphenidate) and other drugs

                                    Daytrana (methylphenidate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Daytrana (methylphenidate). Please note that only the generic name of each medication is listed below.

                                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    drug-cost

                                    How much does Daytrana (methylphenidate) cost?

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                                    contraindications-icon

                                    Daytrana (methylphenidate) contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Daytrana (methylphenidate) will not be safe for you to take.
                                    alternatives

                                    What are alternatives to Daytrana (methylphenidate)?

                                    There are a number of medications that your doctor can prescribe in place of Daytrana (methylphenidate). Compare a few possible alternatives below.
                                    Daytrana (methylphenidate)
                                    Used for:
                                    • ADHD (attention deficit-hyperactivity disorder) in children ages 6 to 17 years

                                    $27.55 Lowest GoodRx priceView Prices
                                    Used for:
                                    • Attention-deficit hyperactivity disorder (ADHD)

                                    $22.50 Lowest GoodRx priceView Prices
                                    Used for:
                                    $380.05 Lowest GoodRx priceView Prices

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                                    References

                                    Best studies we found

                                    Centers for Disease Control and Prevention. (2024). Diagnosis for tic disorders.

                                    Drugs@FDA: FDA-Approved Drugs. (n.d.). Daytrana. U.S. Food and Drug Administration.

                                    Findling, R. L., et al. (2014). Transdermal therapy for attention-deficit hyperactivity disorder with the methylphenidate patch (MTS). Central Nervous System Drugs.

                                    View All References (10)

                                    MedlinePlus. (2023). Prescription drug misuse.

                                    National Institute of Neurological Disorders and Stroke. (2024). Tourette syndrome.

                                    Noven Pharmaceuticals, Inc. (2023). Instructions for use: Daytrana® (day-TRON-ah) (methylphenidate transdermal system) CII.

                                    Noven Therapeutics, LLC. (2024). Daytrana- methylphenidate patch [package insert]. DailyMed.

                                    Shoptaw, S. J., et al. (2009). Treatment for amphetamine withdrawal. The Cochrane Database of Systematic Reviews.

                                    U.S. Food and Drug Administration. (2016). FDA drug safety communication: FDA reporting permanent skin color changes associated with use of Daytrana patch (methylphenidate transdermal system) for treating ADHD.

                                    U.S. Food and Drug Administration. (2022). Drug disposal: Drug take back locations.

                                    U.S. Food and Drug Administration. (2024). Some medicines and driving don’t mix.

                                    Verghese, C., et al. (2023). Methylphenidate. StatPearls.

                                    Zorn, S. Z. (2015). The safety of stimulant medication use in cardiovascular and arrhythmia patients. American College of Cardiology.

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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