Medications for atrophic vaginitis are used to treat vaginal dryness, itching, and discomfort. Some of these medications also have other uses, such as managing menopause symptoms. They work by replacing or mimicking estrogen to help restore vaginal tissue and moisture. Common classes include estrogens and selective estrogen receptor modulators (SERMs). Estrogens, such estradiol (Vagifem, Estrace) and conjugated estrogens (Premarin), are available in forms such as vaginal tablets, oral pills, and creams. SERMs like ospemifene (Osphena) are usually taken as oral pills. These options provide different ways to help manage your symptoms effectively.