Zymfentra vs. Remicade for Ulcerative Colitis and Crohn's Disease: Important Differences and Potential Risks.

Zymfentra

(infliximab)

Remicade

(infliximab)

Summary for Zymfentra

Prescription only

Zymfentra (infliximab or infliximab-dyyb) is an injectable biologic medication for moderate-to-severe ulcerative colitis and Crohn's disease. It's a monoclonal antibody called a tumor necrosis factor (TNF) blocker. Zymfentra (infliximab) is a maintenance treatment that's injected under the skin once every 2 weeks at home, either by yourself or with the help of a caregiver. It's approved for adults who've already had 10 weeks of treatment with an intravenous (IV) infliximab product like Remicade (infliximab). Side effects of Zymfentra (infliximab) include reactions at the injection site. It can also raise your risk for infection.

Indications for Zymfentra

Maintenance treatment of moderate-to-severe ulcerative colitis (UC) after 10 weeks of infliximab treatment through the vein (IV).
Maintenance treatment of moderate-to-severe Crohn's disease (CD) after 10 weeks of IV infliximab treatment.

Pros and Cons for Zymfentra

Pros

Injected every 2 weeks
Available as prefilled syringes and pens so you can inject the medication at home
Can help people achieve remission

Cons

Must be injected
Can raise the risk for infections
Not recommended to take with other biologics (e.g., Humira (adalimumab), Kineret (anakinra)) because of the risk for infections

Common Side Effects for Zymfentra

People with ulcerative colitis:

COVID-19 symptoms (10%)
Anemia (5%)
Joint pain (4%)
Reaction at the injection site (e.g., bruising, swelling, pain, redness; 3%)
Elevated liver enzyme levels (3%)
Belly pain (3%)

People with Crohn's disease:

COVID-19 symptoms (10%)
Headache (8%)
Upper respiratory infections (7%)
Reaction at the injection site (e.g., bruising, swelling, pain, redness; 5%)
Diarrhea (5%)
Higher creatine phosphokinase levels (4%)
Joint pain (4%)
Elevated liver enzyme levels (4%)

Warnings for Zymfentra

Serious infections
Possible risk of cancer
Liver problems
Heart failure
Low blood cell counts
Serious allergic reaction
Effects on the nervous system
Interaction with vaccines

Summary for Remicade

Prescription only

Remicade (infliximab) is an injectable medication used to treat many autoimmune conditions, including ulcerative colitis and Crohn's disease. It's given through an intravenous (IV) infusion by a healthcare provider.

Indications for Remicade

Moderate-to-severe Crohn's disease (CD)
Moderate-to-severe ulcerative colitis (UC)
Moderate-to-severe rheumatoid arthritis (RA)
Ankylosing spondylitis (AS)
Psoriatic arthritis (PsA)
Severe plaque psoriasis (PsO)

Pros and Cons for Remicade

Pros

Can be used for many autoimmune conditions
Typically only needs to be given every 6 to 8 weeks
Can be used in children 6 years of age and older for UC and CD

Cons

Can only be given as an IV infusion by a healthcare professional
Can cause a lot of side effects
Brand name only, which can be expensive

Common Side Effects for Remicade

Infections
Nausea
Infusion-related reactions (e.g., headache, flushing, shortness of breath, rash)
Headache
Diarrhea
Stomach pain
Sore throat
Cough
Rash
Bronchitis
Indigestion
Tiredness
General pain
Joint pain

Warnings for Remicade

Serious or deadly infections
Cancer
Liver problems and liver failure
Heart problems
Low blood cell counts
Nervous system problems
Medications to avoid

Prices with our coupons for Zymfentra vs. Remicade

Zymfentra2 cartons / 2 pens of 120mg/ml

$6,424.28$14,670.94

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Remicade4 vials / 100mg

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Zymfentra vs. Remicade

Zymfentra

Remicade

Summary for Zymfentra

Indications for Zymfentra

Pros and Cons for Zymfentra

Pros

Cons

Common Side Effects for Zymfentra

Warnings for Zymfentra

Summary for Remicade

Indications for Remicade

Pros and Cons for Remicade

Pros

Cons

Common Side Effects for Remicade

Warnings for Remicade

Prices with our coupons for Zymfentra vs. Remicade

Browse medications by letter

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Zymfentra

Remicade

Summary for Zymfentra

Indications for Zymfentra

Pros and Cons for Zymfentra

Pros

Cons

Common Side Effects for Zymfentra

Warnings for Zymfentra

Summary for Remicade

Indications for Remicade

Pros and Cons for Remicade

Pros

Cons

Common Side Effects for Remicade

Warnings for Remicade