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Zymfentra vs. Remicade

Zymfentra (infliximab or infliximab-dyyb) is an injectable biologic medication for moderate-to-severe ulcerative colitis and Crohn's disease. It's a monoclonal antibody called a tumor necrosis factor (TNF) blocker. Zymfentra (infliximab) is a maintenance treatment that's injected under the skin once every 2 weeks at home, either by yourself or with the help of a caregiver. It's approved for adults who've already had 10 weeks of treatment with an intravenous (IV) infliximab product like Remicade (infliximab). Side effects of Zymfentra (infliximab) include reactions at the injection site. It can also raise your risk for infection.

• Maintenance treatment of moderate-to-severe ulcerative colitis (UC) after 10 weeks of infliximab treatment through the vein (IV).
• Maintenance treatment of moderate-to-severe Crohn's disease (CD) after 10 weeks of IV infliximab treatment.

People with ulcerative colitis:

• COVID-19 symptoms (10%)
• Anemia (5%)
• Joint pain (4%)
• Reaction at the injection site (e.g., bruising, swelling, pain, redness; 3%)
• Elevated liver enzyme levels (3%)
• Belly pain (3%)

People with Crohn's disease:

• COVID-19 symptoms (10%)
• Headache (8%)
• Upper respiratory infections (7%)
• Reaction at the injection site (e.g., bruising, swelling, pain, redness; 5%)
• Diarrhea (5%)
• Higher creatine phosphokinase levels (4%)
• Joint pain (4%)
• Elevated liver enzyme levels (4%)

• Serious infections
• Possible risk of cancer
• Liver problems
• Heart failure
• Low blood cell counts
• Serious allergic reaction
• Effects on the nervous system
• Interaction with vaccines

Remicade (infliximab) is an injectable medication used to treat many autoimmune conditions, including ulcerative colitis and Crohn's disease. It's given through an intravenous (IV) infusion by a healthcare provider.

• Moderate-to-severe Crohn's disease (CD)
• Moderate-to-severe ulcerative colitis (UC)
• Moderate-to-severe rheumatoid arthritis (RA)
• Ankylosing spondylitis (AS)
• Psoriatic arthritis (PsA)
• Severe plaque psoriasis (PsO)

• Infections
• Nausea
• Infusion-related reactions (e.g., headache, flushing, shortness of breath, rash)
• Headache
• Diarrhea
• Stomach pain
• Sore throat
• Cough
• Rash
• Bronchitis
• Indigestion
• Tiredness
• General pain
• Joint pain

• Serious or deadly infections
• Cancer
• Liver problems and liver failure
• Heart problems
• Low blood cell counts
• Nervous system problems
• Medications to avoid