Tecentriq
(atezolizumab)
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Summary for Tecentriq
Tecentriq (atezolizumab) is an immunotherapy medication that’s used to treat several different types of cancer, like lung cancer, liver cancer, and melanoma. It turns on your immune system to fight cancer. But this can sometimes cause side effects like rash, diarrhea, and lung problems that might need temporary treatment with corticosteroids. Tecentriq (atezolizumab) is given through the vein (intravenously, IV) at an infusion center or provider’s office.
Indications for Tecentriq
- Non-small cell lung cancer (NSCLC)
- Early-stage cancer that’s had surgery and chemotherapy, given by itself
- Cancer that has spread (metastatic), given by itself or with chemotherapy
- Advanced small cell lung cancer (SCLC), given with chemotherapy
- Certain liver cancers that can’t be surgically removed or has spread, given with Avastin (bevacizumab)
- Advanced melanoma in people with a specific mutation, given with other targeted therapy
- Advanced alveolar soft part sarcoma (ASPS)
Pros and Cons for Tecentriq
Pros
- Doesn’t cause side effects, like nausea, vomiting, and hair loss, that are common with traditional chemotherapy
- First-choice treatment option for certain small-cell and non-small-cell lung and liver cancers
- Uses your body’s own immune system to fight cancer
Cons
- Might cause immune-related side effects like diarrhea, rash, and lung problems
- Might require treatment breaks and a corticosteroid to manage side effects
- Given through an IV, which requires using a needle
Common Side Effects for Tecentriq
- Low red blood cells (anemia; up to 69%)
- Other abnormal lab test results (up to 48%)
- Low white blood cells (up to 49%)
- Tiredness (up to 44%)
- Higher liver enzyme levels in blood (up to 38%)
- Cough (up to 26%)
- Lower appetite (up to 23%)
- Trouble breathing (up to 22%)
- Muscle pain (up to 20%)
- Nausea (up to 18%)
Warnings for Tecentriq
- Immune-related side effects
- Infusion reactions
- Stem cell transplant complications
- Harm to unborn baby
Summary for Tecentriq Hybreza
Tecentriq Hybreza (atezolizumab / hyaluronidase) is an immunotherapy cancer medication that’s given as an injection under the skin. It’s FDA approved for some adults with lung cancer, liver cancer, or melanoma. It can also help treat people 12 years and older with alveolar soft part sarcoma (ASPS). A nurse will give the injection into the thigh every 3 weeks at a clinic. Side effects include tiredness, muscle or bone pain, and cough. Depending on your cancer type and treatment plan, you might take Tecentriq Hybreza on its own or with other chemotherapy.
Indications for Tecentriq Hybreza
Certain types of:
- Non-small cell lung cancer (NSCLC) in adults
- Small cell lung cancer (SCLC) in adults
- Liver cancer in adults
- Melanoma in adults
- Alveolar soft part sarcoma (ASPS) in people 12 years and older weighing 88 lbs or more
Pros and Cons for Tecentriq Hybreza
Pros
- Given as an injection under the skin that takes a few minutes
- Given every 3 weeks
Cons
- Must be given by a healthcare professional
- Risk of reactions like chills or flushing during the injection
Common Side Effects for Tecentriq Hybreza
- Low hemoglobin levels (67%)
- Low white blood cells (37%)
- Low sodium levels (46%)
- Higher liver enzyme levels (up to 33%)
- Low calcium levels (22%)
- High potassium levels (21%)
- High calcium levels (20%)
- Tiredness (19%)
- Muscle or bone pain (15%)
Warnings for Tecentriq Hybreza
- Immune-related side effects
- Injection-related reactions
- Complications from stem cell transplants
- Harm to an unborn baby
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