Key takeaways
Silver sulfadiazine (SSD) and Polysporin (bacitracin/polymyxin B) are both topical antibiotics, but they have different uses and availability. Silver sulfadiazine (SSD), available under brands like Silvadene and Thermazene, is a prescription-only cream used to treat or prevent infections in second- and third-degree burns. It works by damaging the protective coverings of bacteria. On the other hand, Polysporin, which contains bacitracin and polymyxin B, is an over-the-counter ointment used to prevent infections in minor cuts, scrapes, and burns. While SSD is typically applied once or twice a day, Polysporin can be used up to three times daily. SSD is not recommended for pregnant women close to their due dates or for babies under two months old, whereas Polysporin is generally safe for most people if used as directed. Additionally, SSD can cause more severe side effects like serious allergic reactions and changes in blood cell levels, while Polysporin's side effects are usually limited to minor skin rashes and itching.
