Key takeaways
Nyquil Cold and Flu (acetaminophen/dextromethorphan/doxylamine) and Advil PM (ibuprofen/diphenhydramine) are both over-the-counter medications, but they serve different purposes. Nyquil Cold and Flu is designed to relieve symptoms of the common cold and flu, such as cough, sore throat, fever, and runny nose. It contains acetaminophen for pain relief, dextromethorphan as a cough suppressant, and doxylamine, an antihistamine that can make you sleepy. On the other hand, Advil PM can help you fall asleep and stay asleep when you have minor aches and pains. It combines ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation, with diphenhydramine, an antihistamine that also causes drowsiness. While both medications can make you sleepy, Nyquil Cold and Flu is more focused on treating cold and flu symptoms, whereas Advil PM is specifically for pain relief and sleep aid. Additionally, Nyquil Cold and Flu comes in both liquid and capsule forms, while Advil PM is available as tablets and liquid gels. Both medications should be used short-term and have potential side effects, including sleepiness and dizziness.
