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Mucinex vs. Cheratussin AC

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Guaifenesin ER (Mucinex ER, Mucus Relief ER) and codeine/guaifenesin (Cheritussin AC) are both used to treat cough, but they have some key differences. Guaifenesin ER is an over-the-counter expectorant that helps loosen mucus in your chest, making it easier to cough up. It is taken every 12 hours and is generally well-tolerated with few side effects. On the other hand, codeine/guaifenesin is a prescription-only medication that combines an expectorant with an opioid to both loosen mucus and reduce the urge to cough. It is taken every 4 hours as needed and is meant for short-term use due to the risk of addiction and side effects like drowsiness and nausea. While guaifenesin ER is available as a generic medication, codeine/guaifenesin is also available in generic form but is a controlled substance due to the presence of codeine. Both medications can be used by those 12 and older.

guaifenesin ER

 

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Codeine/guaifenesin

 

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Summary for Mucinex

Over-the-counter

Guaifenesin extended-release (ER) is an over-the-counter expectorant used to relieve wet cough. It helps loosen phlegm in the throat and chest so you can cough it up more easily. Guaifenesin ER can be taken orally by adults and children 12 years and older, typically every 12 hours as needed. Most people experience few to no side effects after taking this medication as directed. Guaifenesin ER is available as a brand-name and generic medication.

Indications for Mucinex

  • Loosens and breaks up mucus in the airways (chest congestion)

Pros and Cons for Mucinex

Pros

  • Available as a lower-cost generic medication
  • Taken by mouth
  • Longer-lasting compared to guaifenesin IR

Cons

  • Tablets can't be cut or crushed
  • Not meant to be taken long-term
  • Guaifenesin in many over-the-counter products, so you can accidentally take too much

Common Side Effects for Mucinex

  • Nausea
  • Diarrhea
  • Dizziness
  • Headache

Warnings for Mucinex

  • Accidentally taking too much medication (overdose)

Summary for Cheratussin AC

Prescription only

Codeine/guaifenesin is a cough syrup that contains an expectorant and an opioid. It's used to help loosen mucus and calm coughs in adults and older children. Codeine/guaifenesin is taken by mouth, typically every 4 hours as needed. But it's meant for short-term use only because it contains codeine, which is a controlled substance and can be habit-forming. Some side effects of codeine/guaifenesin include sleepiness and nausea. Brand name Cheratussin AC has been discontinued.

Indications for Cheratussin AC

  • Temporarily easily cough from throat or lung irritations
  • Loosens mucus so that its easier to cough up

Pros and Cons for Cheratussin AC

Pros

  • Available as a lower-cost generic medication
  • Helps you cough less often
  • A possible option for people who can't swallow pills

Cons

Common Side Effects for Cheratussin AC

Warnings for Cheratussin AC

  • Potential for addiction and misuse
  • Short-term use only
  • Not for children under 12 years old
  • Dangerous interactions

Prices with our coupons for Mucinex vs. Cheratussin AC

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Guaifenesin ER60 tablets / 600mg
$25.07-
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Guaifenesin/Codeine120 ml / 100mg/10mg/5ml
$9.90$20.56
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