Compare Methyltestosterone vs. Depo-Testosterone

Methyltestosterone (Methitest) and testosterone cypionate (Depo-Testosterone) are both used to treat low testosterone in males, but they have some key differences. Methyltestosterone is taken orally, while testosterone cypionate is given as an injection. Methyltestosterone can also be used to treat breast cancer in females and delayed puberty in males. Methyltestosterone has a higher risk of causing serious liver damage, while testosterone cypionate is more likely to cause heart attack and stroke if misused. Both medications are available as a lower-cost generic, potentially making treatment less expensive. Testosterone cypionate can be injected once every 2 to 4 weeks at home, whereas methyltestosterone must be taken daily. Both medications carry risks of misuse, dependency, and serious side effects, so they’re both considered controlled medications.