Inrebic vs. Jakafi for Myelofibrosis: Important Differences and Potential Risks.

Inrebic

(fedratinib)

Jakafi

(ruxolitinib)

Summary for Inrebic

Prescription only

Inrebic (fedratinib) is a medication used to treat a rare type of blood cancer called myelofibrosis (MF) in adults. It’s a JAK inhibitor that helps stop abnormal blood cells from growing too much. This medication is a tablet that you take by mouth once a day. But common side effects include diarrhea, nausea, and anemia (low red blood cells). There’s also a risk of a serious brain problem called Wernicke encephalopathy.

Indications for Inrebic

Intermediate or high-risk myelofibrosis (MF) in adults

Pros and Cons for Inrebic

Pros

Taken by mouth once a day
Can help shrink an enlarged spleen, which can improve comfort
Can help control MF symptoms, like tiredness and night sweats

Cons

Often causes diarrhea and anemia
Must also take vitamin B1 every day to lower the risk of a rare brain problem (Wernicke encephalopathy)
Can interact with other medications, like fluconazole (Diflucan) and certain antibiotics

Common Side Effects for Inrebic

Anemia (low red blood cells, 74%)
Diarrhea (66%)
Nausea (62%)
Higher creatinine levels (59%)
Low platelets (47%)
Higher liver enzyme levels (up to 43%)
Vomiting (39%)
Higher lipase levels (35%)
Low sodium (26%)
Higher amylase levels (24%)
Low white blood cells (23%)

Warnings for Inrebic

Serious brain problems, including Wernicke encephalopathy
Anemia and low platelets
Nausea, vomiting, and diarrhea
Serious liver problems
Higher digestive protein levels
Eye inflammation
Possible serious health outcomes, like heart-related death, heart attack, and stroke
Possible blood clots
New cancers
Worsening of symptoms after pausing or stopping treatment

Summary for Jakafi

Prescription only

Jakafi (ruxolitinib) is a JAK inhibitor. It's used to treat adults with certain blood conditions called myelofibrosis (MF) and polycythemia vera (PV). This medication can also treat graft-versus-host disease (GVHD) in people 12 years and older. Jakafi (ruxolitinib) comes as a tablet that's taken by mouth twice a day. There's also Jakafi XR (ruxolitinib), the extended-release version that's taken once a day. Side effects can include low blood cell counts, infection, and dizziness.

Indications for Jakafi

Intermediate or high-risk myelofibrosis (MF) in adults
Polycythemia vera (PV) in adults who can’t take or have already tried hydroxyurea
Acute graft-versus-host disease (aGVHD) in people 12 years and older who’ve already tried steroids
Chronic graft-versus-host disease (cGVHD) in people 12 years and older who’ve already tried at least another therapy

Pros and Cons for Jakafi

Pros

Taken by mouth
A recommended treatment option for certain people with myelofibrosis and polycythemia vera

Cons

Often causes low blood cell counts
Can raise your risk of serious infections

Common Side Effects for Jakafi

Anemia (low red blood cells, 96%)
Low platelets (70%)
Bruising (23%)
Low white blood cells (19%)
Dizziness (18%)
Headache (15%)

Warnings for Jakafi

Low blood cell counts
Risk of infection
Worsening of symptoms after pausing or stopping Jakafi (ruxolitinib)
Possible higher cholesterol levels
Risk of skin cancer
Possible risk of serious heart problems and stroke
Possible risk of blood clots
Possible risk of new cancers

Prices with our coupons for Inrebic vs. Jakafi

Inrebic60 capsules / 100mg

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Jakafi60 tablets / 10mg

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Inrebic vs. Jakafi

Inrebic

Jakafi

Summary for Inrebic

Indications for Inrebic

Pros and Cons for Inrebic

Pros

Cons

Common Side Effects for Inrebic

Warnings for Inrebic

Summary for Jakafi

Indications for Jakafi

Pros and Cons for Jakafi

Pros

Cons

Common Side Effects for Jakafi

Warnings for Jakafi

Prices with our coupons for Inrebic vs. Jakafi

Browse medications by letter

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Inrebic

Jakafi

Summary for Inrebic

Indications for Inrebic

Pros and Cons for Inrebic

Pros

Cons

Common Side Effects for Inrebic

Warnings for Inrebic

Summary for Jakafi

Indications for Jakafi

Pros and Cons for Jakafi

Pros

Cons

Common Side Effects for Jakafi

Warnings for Jakafi