Key takeaways
Fluvastatin (Lescol XL) and rosuvastatin (Crestor) are both statins used to treat high cholesterol and lower the risk of heart-related problems like heart attacks and strokes. They work by blocking a protein in the liver that makes cholesterol. However, they differ in several ways. Fluvastatin is a low-to-moderate intensity statin, while rosuvastatin is a moderate-to-high intensity statin, meaning rosuvastatin can lower cholesterol levels more effectively. Fluvastatin is available in immediate-release capsules and extended-release tablets, while rosuvastatin comes in oral tablets. Both medications are available as lower-cost generics. Common side effects of fluvastatin include headache and indigestion, while rosuvastatin may cause muscle pain and joint pain. Both medications can cause serious side effects like liver problems and rhabdomyolysis, a severe muscle condition. You should avoid alcohol with both medications to reduce the risk of liver issues. Additionally, fluvastatin should not be taken with cyclosporine (Gengraf, Neoral, Sandimmune) or fluconazole (Diflucan) due to interactions, while rosuvastatin requires caution with cyclosporine and warfarin (Coumadin, Jantoven). Neither medication is recommended during pregnancy or breastfeeding.
