How Much Is Cobenfy Without Insurance?
Cobenfy can cost over $2,000 for a 30-day supply without insurance. Learn more about how much Cobenfy costs without insurance with this guide from GoodRx.
Cobenfy
Used for Schizophrenia
Used for Schizophrenia
Cobenfy (xanomeline / trospium) is a prescription medication used to treat schizophrenia in adults. It's a combination of two medications: xanomeline (a muscarinic agonist) and trospium (a muscarinic antagonist). Cobenfy (xanomeline / trospium) works differently from traditional antipsychotic medications because it doesn’t target dopamine receptors. It comes as a capsule you take by mouth twice a day on an empty stomach. Common side effects include nausea, indigestion, constipation, and vomiting.
What is Cobenfy (xanomeline / trospium)?
What is Cobenfy (xanomeline / trospium) used for?
- Schizophrenia in adults
How Cobenfy (xanomeline / trospium) works
Cobenfy is a combination of two medications, but how it works isn't completely clear.
- Xanomeline is a muscarinic agonist. It activates muscarinic receptors in the brain that affect thinking and behavior. This is thought to help reduce symptoms of schizophrenia like hallucinations and delusions.
- Trospium is a muscarinic antagonist. It blocks similar receptors outside the brain, which can help reduce side effects like diarrhea, sweating, vomiting, and stomach cramps.
Drug facts
| Common Brands | Cobenfy |
|---|---|
| Drug Class | Muscarinic agonist / Muscarinic antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Cobenfy (xanomeline / trospium) essentials
Side effects of Cobenfy (xanomeline / trospium)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea (19%)
- Indigestion (18%)
- Constipation (17%)
- Vomiting (15%)
- High blood pressure (11%)
- Stomach pain (8%)
- Diarrhea (6%)
Less Common Side Effects
- Fast heart rate
- Dizziness
- Acid reflux
- Dry mouth
- Sleepiness
- Blurry vision
- Too much saliva
- Cough
Cobenfy (xanomeline / trospium) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: swelling of the face, lips, tongue, or throat; trouble breathing
The following Cobenfy (xanomeline / trospium) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Anticholinergic toxicity—flushed face, blurry vision, dry mouth and skin, confusion, fast or irregular heartbeat, trouble passing urine, constipation
- Constipation, bloating, nausea or vomiting, stomach pain, which may be signs of slow movement through the digestive tract
- Fast or irregular heartbeat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Trouble passing urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Dizziness
- Heartburn
- Nausea
- Stomach pain
- Upset stomach
- Vomiting
Get your GoodRx coupon
$2231.28
GoodRx discount
$1817.77
Pros and cons of Cobenfy (xanomeline / trospium)
Pros
- Works differently from other schizophrenia medications
- Lower risk of weight gain compared to older antipsychotics
- Less movement-related side effects compared to antipsychotics
Cons
- Must be taken twice a day on an empty stomach
- Commonly causes nausea, constipation, and vomiting
- Not recommended for people with certain kidney or liver problems
Pharmacist tips for Cobenfy (xanomeline / trospium)
- Take Cobenfy (xanomeline / trospium) twice a day on an empty stomach to help the medication work properly. That means take it at least 1 hour before a meal or 2 hours after eating.
- Swallow Cobenfy (xanomeline / trospium) capsules whole. Don't chew, open, or break them. If you're having trouble swallowing pills, talk to your prescriber.
- Cobenfy (xanomeline / trospium) commonly causes stomach-related side effects, such as nausea, indigestion, constipation, and vomiting. These are usually mild, but tell your prescriber if they get worse or don’t go away.
- Cobenfy (xanomeline / trospium) might affect how you think, focus, and react. You might also feel dizzy or have blurry vision. Don’t drive or use heavy equipment until you know how the medication affects you.
- Cobenfy (xanomeline / trospium) can raise your heart rate. Your prescriber might check your heart rate before and during treatment. Tell your care team if you notice a fast or irregular heartbeat.
- Cobenfy (xanomeline / trospium) can make it hard to urinate, especially in older adults or people with bladder problems. Watch for signs like weak flow, pain, or not feeling like your bladder is empty. If you can’t urinate at all, get medical help right away.
- Some people might have a serious allergic reaction to Cobenfy (xanomeline / trospium). Get help right away if your tongue or throat swells or you have trouble breathing. Stop taking the medication and call your care team immediately if this happens.
- Cobenfy (xanomeline / trospium) can interact with many common medications. Tell your care team about everything you're taking, including over-the-counter drugs and supplements. Don’t start anything new without checking with your prescriber or pharmacist first.
- Tell your prescriber if you're pregnant or think you might be while taking Cobenfy (xanomeline / trospium). They can help you decide if it's safe to keep taking during pregnancy. If so, you’re encouraged to join the pregnancy registry to help track health outcomes.
Risks and warnings for Cobenfy (xanomeline / trospium)
Cobenfy (xanomeline / trospium) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Trouble urinating
- Risk factors: Older adults | History of bladder conditions | Enlarged prostate | Moderate-to-severe kidney problems
Cobenfy (xanomeline / trospium) can make it harder for your bladder to empty fully. This might occur at any time during treatment and is more likely with higher doses. It can also raise your risk of a urinary tract infection (UTI). Your risk is higher if you're an older adult or have certain conditions like an enlarged prostate (also called benign prostatic hyperplasia, or BPH).
Watch for signs like trouble starting to urinate, a weak or slow stream, going more often than usual, feeling like your bladder is full but not emptying, or pain when urinating. Tell your prescriber if you notice any of these symptoms. They might lower your dose, stop the medication, or refer you to a specialist. Get medical help immediately if you can’t urinate at all.
Caution in people with liver problems
If you have liver problems, you might have a higher risk of side effects from Cobenfy (xanomeline / trospium). Tell your prescriber about any liver conditions before starting this medication. They will check your liver with a blood test before treatment and might test while you're taking it. Call your care team if you notice signs of liver problems like yellowing of your skin or eyes, dark urine, stomach pain, itching, nausea, vomiting, loss of appetite, fever, chills, light-colored stools, or feeling very tired.
Caution in people with bile duct and gallbladder problems
Cobenfy (xanomeline / trospium) isn't recommended in people with active gallbladder problems like gallstones. Your prescriber will check your liver and bilirubin levels before starting Cobenfy (xanomeline / trospium). Contact your care team if you experience symptoms like upset stomach, nausea, vomiting, or pain in the upper stomach.
Slow emptying of your stomach
- Risk factors: Ulcerative colitis | Problems with slow stomach emptying | Myasthenia gravis
Cobenfy (xanomeline / trospium) contains trospium, which can slow down how food moves through your gut. If you have certain stomach or muscle conditions — like ulcerative colitis (UC), myasthenia gravis (MG), or a blockage in your gut — this medication could make your symptoms worse. Tell your prescriber about any digestive or muscle-related health problems before starting Cobenfy (xanomeline / trospium).
Serious allergic reaction
Some people who took Cobenfy (xanomeline / trospium) have had a rare but serious side effect called angioedema. This causes swelling in areas like the face, throat, or tongue. Swelling in your throat or tongue can be life-threatening because it can make it hard to breathe. Go to the emergency room right away if you have trouble breathing or sudden swelling around your face or throat.
Caution in people with glaucoma
Cobenfy (xanomeline / trospium) can cause your pupils to get bigger. This can be dangerous if you have a type of eye condition called narrow-angle glaucoma, as it might cause a sudden attack. Tell your prescriber right away if you notice symptoms like red eyes, blurry vision, seeing halos or bright colors around lights, eye pain, nausea or vomiting, or a severe headache.
Rise in heart rate
Cobenfy (xanomeline / trospium) can raise your heart rate. Your prescriber might check your heart rate before you start the medication and during treatment if needed. Let your care team know if you feel a fast or pounding heartbeat while taking this medication.
Caution in people with kidney problems
Cobenfy (xanomeline / trospium) isn't recommended if you have moderate or severe kidney problems because the medication can build up in your body. This can raise the chance of side effects like dry mouth, constipation, indigestion, urinary tract infections (UTIs), or trouble urinating. Talk to your prescriber if you have kidney problems before starting this medication.
Nervous system side effects
Cobenfy (xanomeline / trospium) can cause side effects like sleepiness, dizziness, confusion, and seeing or hearing things that aren’t there (hallucinations). These side effects are more likely to happen when you first start the medication or when your dose changes. Avoid driving or doing anything that needs your full attention until you know how this medication affects you. Let your care team know if you're experiencing any of these side effects, especially if they affect your usual daily activities. They might lower your dose or stop the medication if needed.
Cobenfy (xanomeline / trospium) dosage
The average cost for 60 capsules of 50mg/20mg of of Cobenfy (xanomeline / trospium) is $0.00 with a free GoodRx coupon. This is 100.00% off the average retail price of $2,203.10.
Typical dosage for Cobenfy (xanomeline / trospium)
The typical starting dose is 50 mg/20 mg (xanomeline/trospium) by mouth twice a day on an empty stomach — 1 hour before or 2 hours after a meal — for at least 2 days. After that, the dose is usually raised to 100 mg/20 mg (xanomeline/trospium) twice a day for at least 5 days. If needed, your prescriber might raise the dose again to 125 mg/30 mg (xanomeline/trospium) twice a day.
The dose might differ for older adults.
How much does Cobenfy (xanomeline / trospium) cost?
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Cobenfy (brand)
$0.00
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Cobenfy (xanomeline / trospium) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cobenfy (xanomeline / trospium) will not be safe for you to take.
- Trouble emptying your bladder
- Moderate or severe liver problems
- Slow emptying of the stomach
- Allergy to xanomeline or trospium
- Untreated narrow-angle glaucoma
What are alternatives to Cobenfy (xanomeline / trospium)?
There are a number of medications that your doctor can prescribe in place of Cobenfy (xanomeline / trospium). Compare a few possible alternatives below.
