Cobenfy

• Risk factors: Older adults | History of bladder conditions | Enlarged prostate | Moderate-to-severe kidney problems

Cobenfy (xanomeline / trospium) can make it harder for your bladder to empty fully. This might occur at any time during treatment and is more likely with higher doses. It can also raise your risk of a urinary tract infection (UTI). Your risk is higher if you're an older adult or have certain conditions like an enlarged prostate (also called benign prostatic hyperplasia, or BPH).

Watch for signs like trouble starting to urinate, a weak or slow stream, going more often than usual, feeling like your bladder is full but not emptying, or pain when urinating. Tell your prescriber if you notice any of these symptoms. They might lower your dose, stop the medication, or refer you to a specialist. Get medical help immediately if you can’t urinate at all.

If you have liver problems, you might have a higher risk of side effects from Cobenfy (xanomeline / trospium). Tell your prescriber about any liver conditions before starting this medication. They will check your liver with a blood test before treatment and might test while you're taking it. Call your care team if you notice signs of liver problems like yellowing of your skin or eyes, dark urine, stomach pain, itching, nausea, vomiting, loss of appetite, fever, chills, light-colored stools, or feeling very tired.

Cobenfy (xanomeline / trospium) isn't recommended in people with active gallbladder problems like gallstones. Your prescriber will check your liver and bilirubin levels before starting Cobenfy (xanomeline / trospium). Contact your care team if you experience symptoms like upset stomach, nausea, vomiting, or pain in the upper stomach.

• Risk factors: Ulcerative colitis | Problems with slow stomach emptying | Myasthenia gravis

Cobenfy (xanomeline / trospium) contains trospium, which can slow down how food moves through your gut. If you have certain stomach or muscle conditions — like ulcerative colitis (UC), myasthenia gravis (MG), or a blockage in your gut — this medication could make your symptoms worse. Tell your prescriber about any digestive or muscle-related health problems before starting Cobenfy (xanomeline / trospium).

Some people who took Cobenfy (xanomeline / trospium) have had a rare but serious side effect called angioedema. This causes swelling in areas like the face, throat, or tongue. Swelling in your throat or tongue can be life-threatening because it can make it hard to breathe. Go to the emergency room right away if you have trouble breathing or sudden swelling around your face or throat.

Cobenfy (xanomeline / trospium) can cause your pupils to get bigger. This can be dangerous if you have a type of eye condition called narrow-angle glaucoma, as it might cause a sudden attack. Tell your prescriber right away if you notice symptoms like red eyes, blurry vision, seeing halos or bright colors around lights, eye pain, nausea or vomiting, or a severe headache.

Cobenfy (xanomeline / trospium) can raise your heart rate. Your prescriber might check your heart rate before you start the medication and during treatment if needed. Let your care team know if you feel a fast or pounding heartbeat while taking this medication.

Cobenfy (xanomeline / trospium) isn't recommended if you have moderate or severe kidney problems because the medication can build up in your body. This can raise the chance of side effects like dry mouth, constipation, indigestion, urinary tract infections (UTIs), or trouble urinating. Talk to your prescriber if you have kidney problems before starting this medication.

Cobenfy (xanomeline / trospium) can cause side effects like sleepiness, dizziness, confusion, and seeing or hearing things that aren’t there (hallucinations). These side effects are more likely to happen when you first start the medication or when your dose changes. Avoid driving or doing anything that needs your full attention until you know how this medication affects you. Let your care team know if you're experiencing any of these side effects, especially if they affect your usual daily activities. They might lower your dose or stop the medication if needed.