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Clorpres

Clonidine And Chlorthalidone
Used for Hypertension
Used for Hypertension

Chlorthalidone/clonidine is convenient for people who need more than one medication to help lower their blood pressure. This combination medication is no longer available in the United States because it was discontinued.

Reviewed by:
reviewer
Michelle Nguyen, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on January 10, 2022
BasicsFAQsInteractionsPricesMedicare
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What is Chlorthalidone/clonidine?

How Chlorthalidone/clonidine works

Are you looking for information on chlorthalidone or clonidine (Catapres) instead?

Drug Facts

Common BrandsClorpres (brand no longer available)
Drug ClassDiuretic (water pill) / Alpha agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Chlorthalidone/clonidine

What is chlorthalidone/clonidine?
Chlorthalidone/clonidine is made up of two medications that lower your blood pressure. Chlorthalidone is a thiazide-like diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, which lowers blood pressure and gets rid of swelling. Clonidine is an alpha agonist that lowers blood pressure by telling the brain to lower the activity of stress hormones. Fewer stress hormones leads to more relaxed blood vessels.
Is chlorthalidone/clonidine still available?
No, chlorthalidone/clonidine has been discontinued and is no longer available in the United States.
Why was chlorthalidone/clonidine discontinued?
It's not clear why chlorthalidone/clonidine has been discontinued by the FDA, but it wasn't taken off of the market because of any issues about safety or how well it works. The individual medications, clonidine and chlorthalidone, are still available as separate medications.
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interactions

Interactions between Chlorthalidone/clonidine and other drugs

Chlorthalidone/clonidine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Chlorthalidone/clonidine. Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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