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Climara Pro

Climara Pro Side Effects

Cydnee Ng, PharmDKristianne Hannemann, PharmD
Reviewed by Cydnee Ng, PharmD, Kristianne Hannemann, PharmD
Last reviewed on July 24, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Application site reaction (e.g., skin irritation; 41%)
  • Vaginal bleeding or spotting (37%)
  • Breast pain (19%)
  • Upper respiratory infection (13%)
  • Depression (6%)
  • Back pain (6%)
  • General pain (5%)
  • Headache (5%)
  • Flu-like symptoms (5%)

Less Common Side Effects

  • Stomach pain
  • Gas
  • Joint pain
  • Swelling
  • Weight gain
  • High blood pressure
  • Bronchitis
  • Sinus infection
  • Other infection
  • Urinary tract infection (UTI)
  • Vaginal inflammation, discharge, itching, or pain
  • Rash

Climara Pro serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot: trouble breathing, leg pain or swelling, skin that's warm to the touch
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweat, lightheadedness
  • Stroke: sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache
  • Vaginal bleeding

Source: DailyMed

The following Climara Pro side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Increase in blood pressure
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Vaginal bleeding after menopause, pelvic pain

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Back pain
  • Breast pain or tenderness
  • Headache
  • Irritation at application site
  • Swelling of the ankles, hands, or feet
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