Keratolytics are used to treat dry, tough, or thick skin caused by conditions such as eczema or psoriasis. They also have other uses, such as softening calluses and corns. Keratolytics work by breaking down the outer layer of the skin, which helps to remove dead skin cells and reduce scaling. Keratolytics are typically applied topically. Examples include urea (Keralac, Umecta, Utopic) and cantharidin (Ycanth).