buprenorphine
Buprenorphine patch, also known by its brand name Butrans, treats people with severe chronic (long-term) pain that isn't relieved with other treatment options. It works as an opioid partial agonist to help with pain. Buprenorphine patch (Butrans) is applied onto the skin once per week. This transdermal patch comes in many strengths. The pain specialist will decide on the dosage based on how severe your pain is and whether you were taking opioid pain medication before starting buprenorphine patch (Butrans). Side effects include nausea, dizziness, and headache.
What is Buprenorphine patch (Butrans)?
What is Buprenorphine patch (Butrans) used for?
Severe chronic pain that isn't relieved with non-opioid pain medications
How Buprenorphine patch (Butrans) works
Buprenorphine patch (Butrans) is a type of opioid medication called an opioid partial agonist. It works by attaching to certain opioid receptors (signaling proteins) in the brain. This changes how you react to pain and helps lower how much pain you feel.
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What are the risks and warnings for Buprenorphine patch (Butrans)?
Buprenorphine patch (Butrans) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Potential for addiction and misuse
Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of depression or other mental health condition | Taking more buprenorphine patch (Butrans) than prescribed
The buprenorphine patch (Butrans) is a schedule III controlled substance that has a risk for addiction and misuse. Misusing this medication by placing it in the mouth, chewing it, or swallowing it can lead to choking. Misuse can also raise the risk for serious and fatal side effects, such as dangerously slow breathing and overdose.
Use the buprenorphine patch (Butrans) exactly as prescribed. Don't change the dose or how often you take it without talking to your pain specialist first.
Because of the risk for addiction and misuse, buprenorphine patch (Butrans) is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and discuss with you about how to use the buprenorphine patch (Butrans) safely.
Dangerously slow breathing (respiratory depression)
Risk factors: Taking medications that can cause slow breathing or slow the body down | Drinking alcohol | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Older age | Frail
The buprenorphine patch (Butrans) can cause dangerously slow breathing, which can be life-threatening. Slowed breathing can happen to anyone at recommended doses of the buprenorphine patch (Butrans). But the risk is higher when you first start treatment and when your dose gets raised. The risk is also higher if you take other medications that can slow your body down (e.g., benzodiazepines, opioids), drink alcohol, or have other breathing problems (e.g., asthma).
Your pain specialist might prescribe naloxone (Narcan) for you to have with you at all times so that you can quickly treat very slowed breathing if needed. It's important for you and your loved ones to know how to use naloxone (Narcan) in case you have extremely slowed breathing. Give naloxone (Narcan) and call 911 right away if you have trouble breathing or have bluish-colored lips, fingers, or toes.
Risk for opioid overdose
Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of buprenorphine patch (Butrans) | Taking more opioids than prescribed | Alcohol use
Use the buprenorphine patch (Butrans) exactly as prescribed. Using too much medication or using it more often than prescribed can lead to an overdose. Keep the opioid medication out of reach from children, pets, and visitors to prevent accidental exposure or overdose.
Symptoms of an opioid overdose include not responding to sound or touch, extremely slowed breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your pain specialist will probably prescribe naloxone (Narcan), a medication that can help treat an opioid overdose. Have naloxone with you at all times; use it and call 911 right away if an overdose happens.
Difficulty concentrating and extreme sleepiness
Risk factors: Drinking alcohol | Taking other medications that can cause sleepiness
The buprenorphine patch (Butrans) can cause extreme sleepiness and lower how well you can think, react, and focus. Don't drink alcohol or take other medications that can cause sleepiness or "brain fog" (e.g., opioids, benzodiazepines, muscle relaxants, sleep medications) with the buprenorphine patch (Butrans). Mixing these medications together might make you feel even sleepier or have an even harder time thinking.
Be sure you know how the buprenorphine patch (Butrans) affects you before driving a car or doing activities that require your concentration. Talk to your prescriber right away if you feel too sleepy from the medication.
Harm to newborns when taken during pregnancy
Risk factors: Taking buprenorphine patch (Butrans) long term during pregnancy
Long-term use of the buprenorphine patch (Butrans) during pregnancy can cause your unborn baby to become dependent on the medication. This is because buprenorphine can get to your unborn baby through the placenta. It can cause your baby to have withdrawal symptoms after birth.
Symptoms of withdrawal in your newborn can include high-pitched crying, poor feeding and sucking behavior, and seizures. Withdrawal can be life-threatening for babies if not recognized and treated in time.
Make sure to tell your pain specialist if you've taken the buprenorphine patch (Butrans) during pregnancy. Specialized healthcare professionals will know how to treat your newborn and make sure your baby gets the care they need once they're born.
Serious risks with patch exposure to high temperatures (e.g., heat, high fever)
Risk factors: Exposing the buprenorphine patch (Butrans) to external heat sources | High fever | Very rigorous movement or exercise (leading to a high body temperature)
Exposing the buprenorphine patch (Butrans) to heat or having areas of skin around your patch that's hot raises the risk for opioid side effects. High temperatures — including when you have a high fever or when you exercise rigorously – can cause more medication to get released from the patch and into the body, which can lead to side effects like very slowed breathing and overdose.
Don't use any external heat sources, like heating pads, electric blankets, heat or tanning lamps, heated beds or water beds, over the buprenorphine patch (Butrans) and the area of skin around it. Also avoid sunbathing, hot baths, hot tubs, and saunas. Don't get hot water directly over the area and avoid getting the patch exposed to direct sunlight for too long. Try to avoid extreme workouts, exercise, or movement that can make you get very hot.
Contact a healthcare professional as soon as you can if you have a high fever for appropriate treatment. Call 911 right away if you have any symptoms of overdose, like extreme sleepiness or slowed breathing.
Low adrenal hormone levels
Risk factors: Taking the buprenorphine patch (Butrans) for longer than 1 month
Some people taking opioids experienced a drop in their adrenal hormone levels. Having low adrenal hormone levels is more likely to happen after you take the medication for a month or longer. Tell your pain specialist if you have symptoms of low adrenal hormones, including long-lasting tiredness, muscle weakness, nausea, vomiting, and low appetite. Your pain specialist might discuss with you about stopping the buprenorphine patch (Butrans) and treating you with corticosteroids.
Low blood pressure
Risk factors: Medical conditions that make it hard to have a stable blood pressure | Taking medications that can drop blood pressure
The buprenorphine patch (Butrans) can sometimes cause extremely low blood pressure. This can include a drop in blood pressure when you stand from a sitting or lying down position. Low blood pressure can lead to dizziness and fainting.
To avoid falling, get up slowly if you've been sitting or lying down. Talk to your prescriber if you feel too dizzy or lightheaded or if you notice vision changes.
Liver damage
Risk factors: History of liver damage | Hepatitis B or C infection | Taking other medications that can cause liver damage | Injection drug use | Heavy alcohol use
Some people who took buprenorphine dissolved under the tongue have developed liver damage. This liver damage was sometimes serious. The risk of liver injury from buprenorphine might be higher for people who already have liver problems.
Tell your pain specialist about your medical and social history and the medications you take so they can check your risk for liver damage. If you have or are at risk for liver damage, your pain specialist might recommend that you get blood tests done before you start the buprenorphine patch (Butrans) and periodically during treatment. This helps make sure your liver is healthy.
Let your primary care provider or pain specialist know if you have symptoms of liver problems while you're taking the buprenorphine patch (Butrans). Watch for symptoms such as dark urine, pale stool, and yellowing of the whites of the eyes and skin.
Withdrawal symptoms
Risk factors: Long-term use of the buprenorphine patch (Butrans) | Switching from a different opioid to buprenorphine patch (Butrans)
The buprenorphine patch (Butrans) can cause physical dependence when it's used regularly for a long period of time. This means that your body starts to rely on the medication to function. You might experience withdrawal if you suddenly stop using the medication or if you lower your dose too fast. Withdrawal can make your pain come back and cause unpleasant symptoms like anxiety, restlessness, body aches, stomach upset, and chills.
Don't lower your dose or stop using the buprenorphine patch (Butrans) without talking to your prescriber first. Your prescriber will slowly lower your dose to prevent withdrawal. Talk to your prescriber about alternative pain medications if you have concerns about the risk for dependence and withdrawal with the buprenorphine patch (Butrans).
Seizures
Risk factors: History of seizures | Taking other medications or having health conditions that raise your risk of seizures
If you've had a seizure in the past, opioids like the buprenorphine patch (Butrans) can raise the risk of having seizures more often. This medication can also put you at risk of seizure in certain situations. Get medical help if you have a seizure while you're using the buprenorphine patch (Butrans).
Life-threatening heart rhythm problems (QT prolongation)
Risk factors: Heartbeat or heart rhythm problems | Heart failure | Abnormal electrolyte levels in the body
Buprenorphine can make it take longer for your heart to recharge between beats. This is called QT prolongation and it can sometimes lead to a potentially life-threatening heart rhythm problem.
Tell your pain specialist about your full medical history before you start taking the buprenorphine patch (Butrans). Your risk for QT prolongation might be higher if you already have heart problems or abnormal electrolyte levels in your body.
Contact your pain specialist if you feel symptoms of heart problems while you're taking the buprenorphine patch (Butrans). Look out for symptoms like pounding chest, trouble breathing, feeling faint or lightheaded, or chest pain.
More on Buprenorphine patch (Butrans) warnings
What are the side effects of Buprenorphine patch (Butrans)?
Common Side Effects
- Nausea (21%)
- Itching at the application site (15%)
- Dizziness (15%)
- Headache (14%)
- Sleepiness (13%)
- Constipation (13%)
- Vomiting (9%)
Other Side Effects
- Redness at the application site
- Rash at the application site
- Tiredness
- More sweating
- Swelling in the arms, legs, or ankles
- Dry mouth
- Upset stomach
Serious Side Effects
- Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
- Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, slow heartbeat
- Opioid withdrawal: return of pain, suicidal thoughts, anxiety, restlessness, irritability, body aches, stomach upset, yawning, sweating, chills
- Heart rhythm problems: chest pounding, fluttering in the chest, chest pain, trouble breathing, feeling faint or lightheaded
- Severe skin reaction at the application site: severe inflammation, burning sensation, discharge, blisters
- Serious allergic reaction: rash, hives, itchiness, shortness of breath, trouble breathing, fast heartbeat, dizziness, swelling of the face or tongue
Source:Â DailyMed
More on Buprenorphine patch (Butrans) side effects
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Drowsiness
relaxed and calm feeling
sleepiness
Rare
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
bluish color of the fingernails, lips, skin, palms, or nail beds
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
confusion
difficult or labored breathing
feeling, seeing, or hearing things that are not there
feeling that others are watching you or controlling your behavior
feeling that others can hear your thoughts
headache
severe mood or mental changes
slurred speech
tightness of the chest
unusual behavior
Incidence not known
Agitation
darkening of the skin
deep or fast breathing with dizziness
dizziness
fainting
irregular heartbeats
irritability
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
loss of muscle coordination
nervousness
noisy breathing
overactive reflexes
poor coordination
restlessness
seizures
shaking
shivering
skin rash
sweating
talking or acting with excitement which you cannot control
trouble sleeping
twitching
unusual tiredness or weakness
vomiting
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Blurred vision
confusion
difficult or trouble breathing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
irregular, fast or slow, or shallow breathing
pale or blue lips, fingernails, or skin
pinpoint pupils
relaxed and calm
sleepiness or unusual drowsiness
sweating
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Constricted, pinpoint, or small pupils (black part of the eye)
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extremely shallow or slow breathing
sweating
Rare
Burning, dry, or itching eyes
chills
continuing ringing or buzzing or other unexplained noise in the ears
decrease in the frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
discharge, excessive tearing
dreaming
false or unusual sense of well-being
fast, pounding, or irregular heartbeat or pulse
feeling of warmth
hearing loss
itching of the skin
pounding in the ears
redness of the face, neck, arms, and occasionally, upper chest
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
Incidence not known
Belching
bloated
bluish lips or skin
change in vision
excess air or gas in the stomach or intestines
feeling of fullness
feeling of unreality
general feeling of discomfort or illness
hives or welts
impaired vision
indigestion
not breathing
paleness of the skin
passing gas
redness of the skin
sense of detachment from self or body
stomach discomfort, upset, or pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Buprenorphine patch (Butrans)
Pros
Applied on the skin once per week
An option for people who can't swallow pills
Cons
Has many serious risks, like dangerously slow breathing, misuse, and addiction
Doesn't treat sudden breakthrough pain
Not the best choice for people who need to take large doses of opioids (greater than 80 mg of oral morphine equivalents per day)
Pharmacist tips for Buprenorphine patch (Butrans)
Use the buprenorphine patch (Butrans) exactly as prescribed by your pain specialist. It's recommended to take the lowest dose possible for the shortest amount of time needed for pain relief because this medication has many serious risks, including misuse and overdose. Speak with your prescriber if you have concerns about using the buprenorphine patch (Butrans).
Apply one buprenorphine patch (Butrans) onto the skin once per week. Choose a day of the week that's convenient for you and easy for you to remember. After every 7 days, remove the patch you're wearing and apply a new patch on a different area of skin. Use the patch application site tracker to help you keep track of when you apply the patches. Review the tips below about applying and removing the patches.
Buprenorphine patch (Butrans) can make you feel tired and drowsy. Don't operate any heavy machinery or drive a vehicle until you know how the medication affects you. Also avoid alcohol or other medications that can make you tired, such as sedatives and muscle relaxers, while you're using the patches.
Never change the dose or the number of buprenorphine patches (Butrans) you wear by yourself. Also don't stop using the medication suddenly without talking to your prescriber first. If you need a lower dose or if you need to stop the medication, your pain specialist will work with you to do this slowly over time. This lowers your risk for withdrawal.
Always have naloxone (Narcan) with you. Naloxone helps reverse the effects of buprenorphine in situations like an accidental overdose. Teach your loved ones how to give naloxone to you if you can't do it yourself. Call 911 if you need to use naloxone because its effects are temporary.
Store buprenorphine patches (Butrans) out of reach from children, visitors, and pets to lessen the risk for accidental overdose and medication misuse. Choose a drug take-back option to get rid of the patches safely if you don't need them anymore.
More tips on how to use the buprenorphine patch (Butrans):
Open the pouch and take out the buprenorphine patch (Butrans) only when you're ready to place it on your skin. Be careful not to cut the patch if you're using scissors to open the pouch.
Don't cut the buprenorphine patch (Butrans) into a smaller size. It can affect how much and how fast medication gets released from the patch and into your body. This can lead to serious side effects.
Before you place the buprenorphine patch (Butrans) onto the skin, clean the area of skin with water only and pat completely dry. Don't put any lotion, oils, soap, or alcohol on the skin before you stick the patch on. These products can irritate your skin and affect how well the patch sticks to your skin.
Avoid touching the sticky side of the buprenorphine patch (Butrans) with your fingers after you peel off the clear plastic liners. This can make the patch less sticky. And for people helping you put the patch on, touching the sticky side can expose them to the medication accidentally and put them at risk for serious side effects.
Avoid placing the buprenorphine patch (Butrans) onto skin that's sensitive, burned, cut, irritated, or damaged.
Apply the buprenorphine patch (Butrans) on a flat area of your skin that has no hair. Body hair might make the patch not stick as well. Don't shave to get rid of any body hair where you'll be applying the patch. Instead, clip the hair as close to your skin as possible to avoid irritation.
Where to apply the buprenorphine patch (Butrans): Apply the patch to your upper outer arm, upper chest, upper back, or the side of the chest. Every week when you change your patch, pick a different spot to apply the new patch. Don't reuse an area for at least 21 days (3 weeks). Keep track of where you apply the patches by using the patch application site tracker.
You can shower or bathe as usual while you're wearing the buprenorphine patch (Butrans). But avoid getting hot water on the patch and using hot tubs or saunas. Heat can cause too much medication get released into your body from the patch. This can raise your risk for serious side effects and overdose.
If the edges of the buprenorphine patch (Butrans) start to come off before it's time for a new patch, you can use first-aid tape to stick the outer edges back onto the skin. Don't cover the patch with other types of tape unless your prescriber says so.
If the buprenorphine patch (Butrans) completely falls off before it's time for a new patch, throw the patch away properly and apply a new patch onto a different area of skin. Keep the new patch on for 7 days before you replace it.
How to get rid of the used buprenorphine patch (Butrans): Remove the used patch. Fold the used patch in half so that the sticky sides are together. Then, flush it down the toilet right away. Another option is to place the used patch into the Patch-Disposal Unit before throwing it away in the regular trash. Never throw away the patch into the regular trash without using the Patch-Disposal Unit.
Frequently asked questions about Buprenorphine patch (Butrans)
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Buprenorphine patch (Butrans) dosage forms
Typical dosing for Buprenorphine patch (Butrans)
Your pain specialist will work with you to prescribe the right dose of buprenorphine patch (Butrans) for your individual needs. It's recommended to use the lowest dose possible for the shortest length of time to manage your pain.
In general, your starting dose depends on whether you were taking other opioid pain medications before.
For people who were previously taking opioids with a total daily dose less than 30 mg of oral morphine equivalents per day: The typical starting dose is one 5 mcg/hour buprenorphine patch (Butrans) applied to the skin once per week.
For people who were previously taking opioids with a total daily dose of 30 mg to 80 mg of oral morphine equivalents per day: The typical starting dose is one 10 mcg/hour buprenorphine patch (Butrans) applied to the skin once per week.
Your pain specialist will adjust your dose based on how well the medication is working to manage your pain and whether you have bothersome side effects.
Interactions between Buprenorphine patch (Butrans) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bepridil
- Cisapride
- Dronedarone
- Fluconazole
- Ketoconazole
- Mesoridazine
- Nalmefene
- Naltrexone
- Pimozide
- Piperaquine
- Posaconazole
- Safinamide
- Saquinavir
- Sparfloxacin
- Terfenadine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acecainide
- Acepromazine
- Alfentanil
- Alfuzosin
- Almotriptan
- Alprazolam
- Amineptine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amitriptylinoxide
- Amobarbital
- Amoxapine
- Amphetamine
- Amprenavir
- Anagrelide
- Apomorphine
- Aprepitant
- Aripiprazole
- Aripiprazole Lauroxil
- Armodafinil
- Arsenic Trioxide
- Asenapine
- Astemizole
- Atazanavir
- Azithromycin
- Baclofen
- Bedaquiline
- Benperidol
- Benzhydrocodone
- Benzphetamine
- Boceprevir
- Bosentan
- Bromazepam
- Bromopride
- Brompheniramine
- Buserelin
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Carbamazepine
- Carbinoxamine
- Cariprazine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chloroquine
- Chlorpheniramine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Dabrafenib
- Dantrolene
- Darunavir
- Dasatinib
- Degarelix
- Delamanid
- Delavirdine
- Desipramine
- Deslorelin
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexamethasone
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan
- Dezocine
- Diazepam
- Dibenzepin
- Dichloralphenazone
- Difenoxin
- Diltiazem
- Diphenhydramine
- Diphenoxylate
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Doxylamine
- Droperidol
- Duloxetine
- Ebastine
- Efavirenz
- Eletriptan
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Eribulin
- Erythromycin
- Escitalopram
- Esketamine
- Eslicarbazepine Acetate
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Etravirine
- Famotidine
- Felbamate
- Fenfluramine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluoxetine
- Fluphenazine
- Flurazepam
- Fluspirilene
- Fluvoxamine
- Formoterol
- Fosamprenavir
- Fosaprepitant
- Foscarnet
- Fosphenytoin
- Fospropofol
- Fostemsavir
- Frovatriptan
- Furazolidone
- Gabapentin
- Gabapentin Enacarbil
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Gonadorelin
- Goserelin
- Granisetron
- Halazepam
- Halofantrine
- Haloperidol
- Halothane
- Hexobarbital
- Histrelin
- Hydrocodone
- Hydromorphone
- Hydroquinidine
- Hydroxychloroquine
- Hydroxytryptophan
- Hydroxyzine
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Iproniazid
- Isocarboxazid
- Isoflurane
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ketamine
- Ketazolam
- Ketobemidone
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Levocetirizine
- Levofloxacin
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofepramine
- Lofexidine
- Lomitapide
- Lopinavir
- Lorazepam
- Lorcaserin
- Loxapine
- Lumacaftor
- Lumefantrine
- Lurasidone
- Macimorelin
- Magnesium Oxybate
- Meclizine
- Mefloquine
- Melitracen
- Melperone
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Metaxalone
- Methadone
- Methamphetamine
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metoclopramide
- Metronidazole
- Mibefradil
- Midazolam
- Mifepristone
- Milnacipran
- Mirtazapine
- Mitotane
- Mizolastine
- Moclobemide
- Modafinil
- Molindone
- Moricizine
- Morphine
- Moxifloxacin
- Nafarelin
- Nafcillin
- Nalbuphine
- Naratriptan
- Nefazodone
- Nelfinavir
- Nevirapine
- Nialamide
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Opipramol
- Opium
- Opium Alkaloids
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymorphone
- Ozanimod
- Palbociclib
- Paliperidone
- Palonosetron
- Panobinostat
- Papaveretum
- Paregoric
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenelzine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pipamperone
- Piperacetazine
- Pipotiazine
- Piritramide
- Pitolisant
- Ponesimod
- Potassium Oxybate
- Prazepam
- Prednisone
- Pregabalin
- Primidone
- Probucol
- Procainamide
- Procarbazine
- Prochlorperazine
- Promazine
- Promethazine
- Propafenone
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranitidine
- Ranolazine
- Rasagiline
- Remifentanil
- Remimazolam
- Remoxipride
- Ribociclib
- Rifabutin
- Rifampin
- Rifapentine
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How much does Buprenorphine patch (Butrans) cost?
Buprenorphine patch (Butrans) contraindications
Very slowed breathing (respiratory depression)
Severe asthma
Medical conditions that cause blockage of the stomach passageway
Previous allergic reaction to any buprenorphine medication
What are alternatives to Buprenorphine patch (Butrans)?
Severe chronic pain that isn't relieved with non-opioid pain medications
Osteoarthritis (OA)
Rheumatoid arthritis (RA)
Sudden pain
Menstrual cramps
What is the latest news about Buprenorphine patch (Butrans)?
Buprenorphine patch (Butrans) images
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References
Best studies we foundAnesthesia Patient Safety Foundation. (n.d.). Respiratory depression and opioids.
Benyamin, R., et al. (2008). Opioid complications and side effects. Pain Physician Journal.
Centers for Disease Control and Prevention. (2016). Calculating total daily dose of opioids for safer dosage.
Centers for Disease Control and Prevention. (2024). About opioid use during pregnancy.
Lutfy, K., et al. (2004). Buprenorphine: A unique drug with complex pharmacology. Current Neuropharmacology.
MedlinePlus. (2023). Prescription drug misuse.
MedlinePlus. (2024). Fluid and electrolyte balance.
National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison's disease.
Poliwoda, S., et al. (2022). Buprenorphine and its formulations: A comprehensive review. Health Psychology Research.
Preuss, C. V., et al. (2023). Prescription of controlled substances: Benefits and risks. StatPearls.
Purdue Pharma LP. (2024). Butrans- buprenorphine patch, extended release [package insert]. DailyMed.
Purdue Pharma LP. (n.d.). Patch application site tracker.
Romita, P., et al. (2018). Contact dermatitis due to transdermal therapeutic systems: a clinical update. Acta Biomedica.
Smith, H. S., et al. (2012). Opioid-induced nausea and vomiting. Annals of Palliative Medicine.
U.S. Food and Drug Administration. (2024). Drug disposal: Drug take-back options.
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