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Probuphine

buprenorphine
Used for Opioid Dependence, Pain

Probuphine (buprenorphine) is an implant used with counseling and behavioral therapy for long-term treatment of opioid use disorder. It's placed under the skin on the inside of the upper arm by a trained healthcare provider. Probuphine (buprenorphine) has been discontinued and is no longer available in the United States.

Reviewed by:
reviewerSarah Lobello Pearson, PharmD
reviewerDaisy Chau, PharmD
Last reviewed on January 9, 2023
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What is Probuphine (buprenorphine)?

What is Probuphine (buprenorphine) used for?

  • Opioid use disorder (OUD) in people already stable on low-to-medium doses of under-the-tongue buprenorphine

Drug facts

Common BrandsProbuphine(brand no longer available)
Drug ClassOpioid partial agonist
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Common questions about Probuphine (buprenorphine)

Probuphine (buprenorphine) is an implanted form of the medication buprenorphine, the same active ingredient found in Suboxone and Subutex. Four small rods, delivering a consistent amount of medication, are inserted under the skin in the upper arm, and left in place for 6 months. Probuphine (buprenorphine) is a long-acting partial opioid which binds to opioid receptors in your brain to reduce cravings and prevent withdrawal symptoms.

No, Probuphine (buprenorphine) has been discontinued by the manufacturer, Titan Pharmaceuticals, and is no longer available in the United States.

In October 2020, Titan Pharmaceuticals announced that they were withdrawing Probuphine (buprenorphine) from the U.S. market and that it was no longer possible to start treatment with this medication. The company states that this was a business decision and not related to the safety of the product.

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Probuphine (buprenorphine) dosage

Typical dosage for Probuphine (buprenorphine)

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References

Best studies we found

Titan Pharmaceuticals, Inc. (2020). Titan Pharmaceuticals provides a strategic & corporate update. PRNewswire.

Titan Pharmaceuticals, Inc. (2021). PROBUPHINE- buprenorphine hydrochloride implant.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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