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Probuphine

buprenorphine
Used for Pain, Opioid Dependence
Used for Pain, Opioid Dependence

Probuphine (buprenorphine) is an implant used with counseling and behavioral therapy for long-term treatment of opioid use disorder. It's placed under the skin on the inside of the upper arm by a trained healthcare provider. Probuphine (buprenorphine) has been discontinued and is no longer available in the United States.

Reviewed by:
reviewer
Sarah Lobello Pearson, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on January 9, 2023
BasicsFAQsReferencesPricesMedicare
Probuphine (buprenorphine) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
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What is Probuphine (buprenorphine)?

What is Probuphine (buprenorphine) used for?

  • Opioid use disorder (OUD) in people already stable on low-to-medium doses of under-the-tongue buprenorphine

How Probuphine (buprenorphine) works

Are you looking for information on Sublocade (buprenorphine) injection or buprenorphine sublingual tablet instead?

Drug Facts

Common BrandsProbuphine (brand no longer available)
Drug ClassOpioid partial agonist
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Probuphine (buprenorphine)

What is Probuphine (buprenorphine)?
Probuphine (buprenorphine) is an implanted form of the medication buprenorphine, the same active ingredient found in Suboxone and Subutex. Four small rods, delivering a consistent amount of medication, are inserted under the skin in the upper arm, and left in place for 6 months. Probuphine (buprenorphine) is a long-acting partial opioid which binds to opioid receptors in your brain to reduce cravings and prevent withdrawal symptoms.
Is Probuphine (buprenorphine) still available?
No, Probuphine (buprenorphine) has been discontinued by the manufacturer, Titan Pharmaceuticals, and is no longer available in the United States.
Why was Probuphine (buprenorphine) discontinued?
In October 2020, Titan Pharmaceuticals announced that they were withdrawing Probuphine (buprenorphine) from the U.S. market and that it was no longer possible to start treatment with this medication. The company states that this was a business decision and not related to the safety of the product.
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References

Best studies we found

Titan Pharmaceuticals, Inc. (2020). Titan Pharmaceuticals provides a strategic & corporate update. PRNewswire.

Titan Pharmaceuticals, Inc. (2021). PROBUPHINE- buprenorphine hydrochloride implant.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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