What is Probuphine?

They need to know if you have any of these conditions:

• Addison's disease
• adrenal gland problem
• brain tumor
• head injury
• heart disease
• history of alcoholism
• history of keloid formation or connective tissue disease (such as scleroderma)
• history of skin infections, conditions, or sensitivities
• liver disease
• lung or breathing disease, like asthma
• mental illness
• problems urinating
• prostate disease
• thyroid disease
• an unusual or allergic reaction to buprenorphine, morphine, codeine, other medicines, antiseptics, anesthetics, ethylene vinyl acetate, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

The implants will be inserted under the skin in your upper arm by a specially trained physician in a hospital or clinic setting. Follow your doctor's instructions for care of the area where the implants were inserted. Apply an ice pack to your arm for 40 minutes every 2 hours for the first 24 hours after insertion of the implants and as needed. Removal of the implants will also be done in a hospital or clinic setting by a specially trained physician. Do not try to remove the implants yourself. This could lead to infection or you could experience withdrawal symptoms. Your doctor will decide how long the implants will stay in your arm.

Your healthcare provider will give you a Patient Identification Card to carry with you. Keep track of the date the implants are to be removed. Schedule an appointment with your healthcare provider to remove the implants on or before the removal date.

A special MedGuide will be given to you by your healthcare provider each time this medicine is inserted into your arm. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 16 years for selected conditions, precautions do apply.

This does not apply.

This medicine is inserted in a hospital or clinic and will not be stored at home.