The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Higher blood sugar levels (55%)
- Low blood cell counts, all (up to 50%)
- Muscle or joint pain (up to 45%)
- Cough, runny nose, and other symptoms of an upper respiratory tract infection (up to 44%)
- Bleeding (up to 42%)
- Rash (up to 36%)
- Higher creatinine levels (34%)
- Tiredness (up to 31%)
- Higher liver enzyme levels (up to 28%)
- Changes in electrolyte levels (up to 27%)
- Diarrhea (up to 25%)
- Higher potassium levels (24%)
- Bruising (up to 24%)
Less Common Side Effects
- Nausea
- Headache
- Fever
- Constipation
- Vomiting
- Itching
- Dizziness
- Swelling in the hands and feet
Note: These side effects were reported by people in clinical trials for MCL, MZL, or WM.
Brukinsa serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: body aches, chills, fever, headache, new cough, sore throat, feeling tired, lowered blood cell counts
- Serious bleeding (general): bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
- Brain bleeds: headache, weakness, changes in vision, nausea, vomiting, trouble speaking or understanding speech, difficulty maintaining balance
- Stomach bleeds: dizziness, trouble breathing, feeling faint, stomach pain, nausea, vomiting, bright red blood in vomit, dark and tarry stool
- Heart rhythm problems: fainting, dizziness, chest pain, fast heartbeat, dizziness, difficulty breathing
Source: DailyMed
The following Brukinsa side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Bone, joint, or muscle pain
- Fatigue
- Skin rash
