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Bimzelx

bimekizumab
Used for Plaque Psoriasis
Used for Plaque Psoriasis

Bimzelx (bimekizumab or bimekizumab-bkzx) is an injection that's used to treat several inflammatory conditions in adults. They include plaque psoriasis, psoriatic arthritis, and hidradenitis suppurativa, to name a few. It's a type of monoclonal antibody called an interleukin antagonist. It works to reduce inflammation in the body. Bimzelx (bimekizumab) comes in prefilled autoinjectors or prefilled syringes. You inject the medication under the skin either every month or every other month. Common side effects are upper respiratory infections.

Last reviewed on May 12, 2025
basics-icon

What is Bimzelx (bimekizumab)?

What is Bimzelx (bimekizumab) used for?

How Bimzelx (bimekizumab) works

Bimzelx (bimekizumab) is a monoclonal antibody known as an interleukin antagonist. It blocks interleukin-17A and interleukin-17F (IL-17A, IL-17F). These are proteins in your immune system that play a role in causing inflammation (redness and swelling).

By blocking these proteins, Bimzelx (bimekizumab) calms down the immune system. This helps ease symptoms of certain inflammatory conditions.

When does Bimzelx (bimekizumab) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsBimzelx
Drug ClassInterleukin antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$15982.03
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What are the side effects of Bimzelx (bimekizumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

Note: Side effects listed were reported by adults with plaque psoriasis. Side effects might differ for other conditions.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Tuberculosis (TB): coughing up blood or mucus, weight loss, feeling tired or weak, fever, chills, night sweats
  • Other serious infections: fever, cough, chills, sore throat, runny or stuffy nose, body aches
  • Liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
  • Suicidal thoughts and behavior
When do Bimzelx (bimekizumab) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Injection site reaction
Risk of infection
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Severe or prolonged diarrhea
  • Severe stomach pain
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Cold sores
  • Fatigue
  • Headache
  • Pain, redness, or irritation at injection site
  • Small, red, pus-filled bumps on skin around hair follicles
  • Thrush—white patches in the mouth
pros-and-cons

Pros and cons of Bimzelx (bimekizumab)

thumbs-up

Pros

Dosing schedule is either every month or every other month, so it's convenient for most people

An option for plaque psoriasis if topical medications have stopped working

Available as prefilled autoinjectors and prefilled syringes

thumbs-down

Cons

Can cause injection reactions, such as pain, bruising, and swelling

Might raise the risk of infections

Unknown if safe during pregnancy or while breastfeeding

pharmacist-tips

Pharmacist tips for Bimzelx (bimekizumab)

pharmacist
  • Keep Bimzelx (bimekizumab) in the refrigerator in its original box and away from light. Don't let it freeze. Throw the medication away if it's past the expiration date on the box.

    • You can also keep Bimzelx (bimekizumab) in its box at room temperature (up to 77°F) for up to 30 days. Don't place it back in the refrigerator once it's at room temperature. Don't use it after 30 days at room temperature.

      • The area where you inject Bimzelx (bimekizumab) might get red, swollen, or warm a couple hours afterwards. These reactions usually go away on their own in about 1 to 2 days. You can try using an ice pack wrapped in a towel to help. If it gets worse or doesn't go away, talk to your care team.

        • Before getting any vaccines, tell the healthcare professional you're taking Bimzelx (bimekizumab). They'll check if the vaccine is safe for you. It's not clear how this medication affects how well vaccines work or how safe they are for you. But it's best to avoid live vaccines during treatment to be safe.

          Tips on how to take Bimzelx (bimekizumab)

          • Make sure you understand and are comfortable with how to inject Bimzelx (bimekizumab) before doing it yourself. Your healthcare professional will show you how to inject it your first time. Ask your care team if you have questions.

            • Check with your prescriber about when to inject Bimzelx (bimekizumab). Your dosing schedule depends on what you're using the medication for.

              • Before injecting Bimzelx (bimekizumab): Take it out of the refrigerator and let it come to room temperature. This should take about 30 to 45 minutes. Don't microwave, run hot water over it, or leave it in direct sunlight. Then, wash your hands with soap and water and clean the injection area with an alcohol swab.

                • Where to inject Bimzelx (bimekizumab): Inject the medication under the skin of the belly or thigh. You can also inject it into the back of your upper arm with someone's help. Don't inject into bruised, red, tender, or hard skin. Choose a different spot for each injection to avoid skin irritation.

                  • For the Bimzelx (bimekizumab) prefilled syringes: Carefully pull the needle cap off the syringe. Gently pinch and hold a section of skin. Then, insert the needle into the skin at a 45-degree angle. Slowly push the plunger down until all the medication in the syringe is gone and you feel a little resistance. Then, let go of the plunger. The needle will move back into the needle shield by itself.

                    • For the Bimzelx (bimekizumab) prefilled autoinjectors: Take off the cap, place the pen straight against your skin (at a 90-degree angle), and press down. When the injection starts, you'll hear a click and the window on the pen will start to turn yellow. Keep holding it against your skin until the window is all yellow and you hear another click. This means your injection is done (should take about 15 seconds).

                      • Throw away all used autoinjectors, syringes, and needle caps into a sharps container. You can visit the FDA website to learn more about how to throw your sharps away safely to avoid needle-stick injuries.

                        faqs

                        Frequently asked questions about Bimzelx (bimekizumab)

                        Does Bimzelx (bimekizumab) cause weight gain?
                        Current evidence doesn't show that Bimzelx (bimekizumab) causes weight gain. It's not listed as a common or serious side effect in the official prescribing information. If you're worried about your weight, reach out to your primary care provider.
                        Is Bimzelx (bimekizumab) a biologic?
                        Yes, Bimzelx (bimekizumab) is a biologic. This means that it's made from living sources. It's a type of lab-made medication called a monoclonal antibody. Bimzelx (bimekizumab) blocks certain proteins called interleukins from causing inflammation in the body.
                        How long does it take for Bimzelx (bimekizumab) to work?
                        Bimzelx (bimekizumab) usually starts working within 4 weeks for many people with plaque psoriasis. For other approved conditions (like psoriatic arthritis or hidradenitis suppurativa), some people can improve within 2 weeks of starting treatment. Keep in mind that it can take a few months to see the full effects. Talk to your prescriber if you have questions about how long it should take the medication to work for you.
                        Does Bimzelx (bimekizumab) cause hair loss?
                        Hair loss wasn't a common side effect in people taking Bimzelx (bimekizumab). If you notice more hair falling out than usual, talk to a healthcare professional. They can help figure out what might be causing the hair loss and suggest ways to manage this side effect.
                        How long can Bimzelx (bimekizumab) be out of the fridge?
                        If needed, you can keep Bimzelx (bimekizumab) outside of a refrigerator at room temperature for up to 30 days. Once it's out of the fridge, don't put it back in. Write the date you took the medication out of the fridge in the provided space on the box.
                        Can you drink alcohol with Bimzelx (bimekizumab)?
                        There aren't any known interactions between Bimzelx (bimekizumab) and alcohol. But drinking alcohol while taking this medication can raise your risk of side effects. For example, both Bimzelx (bimekizumab) and alcohol can affect the liver. So drinking alcohol during treatment might raise the chance of having liver damage. To stay safe, ask your prescriber about how much alcohol is okay for you to drink.
                        What's the difference between Bimzelx and Skyrizi?
                        Both Bimzelx (bimekizumab) and Skyrizi (risankizumab) are injections that treat plaque psoriasis and psoriatic arthritis. But they're both also used for other conditions. Skyrizi can also help with inflammatory bowel disease (IBD), like Crohn's disease. And Bimzelx can also treat conditions like non-radiographic axial spondyloarthritis, ankylosing spondylitis, and hidradenitis suppurativa. Bimzelx and Skyrizi work in different ways and have different dosing schedules, too. Talk to your prescriber to learn about how they compare.
                        What's the difference between Bimzelx and Cosentyx?
                        Cosentyx (secukinumab) is an injectable medication that's FDA approved to treat all the same conditions as Bimzelx (bimekizumab). Cosentyx can also treat one more condition called enthesitis-related arthritis. Cosentyx can be used in children for certain conditions, but Bimzelx is only for adults. Both are injections under the skin. But Cosentyx can also be given as an intravenous infusion for some conditions. Ask your prescriber about how the two medications compare.
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                        What are the risks and warnings for Bimzelx (bimekizumab)?

                        Bimzelx (bimekizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Suicidal thoughts or behavior

                        • Risk factors: History of depression | History of suicidal thoughts or behavior | Taking other medications that affect mood

                          Some people who took Bimzelx (bimekizumab) had suicidal thoughts or behavior during studies. But it's not too common. Tell your prescriber if you've ever had serious depression or suicidal thoughts. They'll help decide if this medication is safe for you.

                          Watch for signs of depression or any unusual changes in mood or behavior while taking Bimzelx (bimekizumab). Let your prescriber know if you notice anything concerning. If you or someone close to you notices suicidal thoughts or behavior, call 911 right away.

                          risk-warning

                          Risk of infections

                          • Risk factors: Active, chronic (long-term), or recurrent infection | History of active or latent tuberculosis (TB)

                            Bimzelx (bimekizumab) can make it harder for your body to fight infections. This can raise your risk of infections, including tuberculosis (TB). These infections can also include sinus infections, fungal infections, stomach infections, and herpes. Serious infections were rare in studies.

                            Before you start Bimzelx (bimekizumab), talk to your prescriber about your medical history. Don't start the medication if you're sick or if you get infections often. Your prescriber will also check you for TB before starting. If you have latent TB, you might need to take antibiotics to help keep it from becoming active during treatment.

                            Tell your prescriber right away if you have any signs of an infection while taking Bimzelx (bimekizumab). Look out for signs like fever, chills, cough, sore throat, weakness, or night sweats.

                            risk-warning

                            Liver problems

                            • Risk factors: History of liver problems

                              Rarely, people taking Bimzelx (bimekizumab) can have higher liver test results. This can sometimes be a sign of liver injury. Because of this, people with liver problems, such as cirrhosis, should avoid this medication.

                              Before starting Bimzelx (bimekizumab), you'll need blood tests done to check your liver. Your prescriber will also ask you to get more blood tests done during treatment to make sure you stay safe. Tell your prescriber right away if you have signs of liver damage. This includes pain in the upper right side of your stomach, yellow skin or eyes, or dark urine. If you show signs of liver damage, your prescriber might tell you to stop taking Bimzelx (bimekizumab).

                              risk-warning

                              Inflammatory bowel disease

                              Some people taking Bimzelx (bimekizumab) have had symptoms of inflammatory bowel disease (IBD). Before you start treatment, tell your prescriber if you have IBD. This medication might not be right for you.

                              Talk to your prescriber if you have symptoms of IBD while taking Bimzelx (bimekizumab). Look out for stomach pain, bloody stools, changes in bathroom habits (like having diarrhea or constipation), or losing weight suddenly. Your prescriber will check for IBD and help you figure out what to do next.

                              risk-warning

                              Interaction with vaccines

                              • Risk factors: Getting live vaccines

                                Before starting Bimzelx (bimekizumab), talk to a healthcare professional about your vaccine history. They'll help make sure you're up to date.

                                We don't fully know how Bimzelx (bimekizumab) affects vaccines. But it might make some vaccines work less well. It could also raise the risk of infection from live vaccines themselves. So, it's best to avoid getting any live vaccines, like MMR (measles, mumps, and rubella vaccine), while taking Bimzelx (bimekizumab).

                                dosage

                                Bimzelx (bimekizumab) dosage forms

                                Typical dosing for Bimzelx (bimekizumab)

                                • Plaque psoriasis

                                  • Starting dose for adults: Inject 320 mg under the skin every 4 weeks for 16 weeks. Then, continue with maintenance treatment.

                                  • Maintenance dose for adults: Inject 320 mg under the skin every 8 weeks. For people weighing 264 lbs or more, you might need to inject every 4 weeks instead.

                                • Psoriatic arthritis, non-radiographic axial spondyloarthritis, or ankylosing spondylitis

                                  • Adults: Inject 160 mg under the skin every 4 weeks.

                                • Hidradenitis suppurativa

                                  • Starting dose for adults: Inject 320 mg under the skin every 2 weeks for 16 weeks. Then, continue with maintenance treatment.

                                  • Maintenance dose for adults: Inject 320 mg under the skin every 4 weeks.

                                More on Bimzelx (bimekizumab) dosage forms

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                                alternatives

                                What are alternatives to Bimzelx (bimekizumab)?

                                There are a number of medications that your doctor can prescribe in place of Bimzelx (bimekizumab). Compare a few possible alternatives below.
                                Bimzelx (bimekizumab)
                                $15982.03 Lowest GoodRx priceView Prices
                                Used for:
                                • Moderate-to-severe plaque psoriasis in people ages 6 years and older

                                • Psoriatic arthritis (PsA) in adults

                                • Ankylosing spondylitis (AS) in adults

                                • Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

                                Used for:
                                $7701.78 Lowest GoodRx priceView Prices

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                                References

                                Best studies we found

                                Camiña-Conforto, G., et al. (2023). Bimekizumab in the treatment of plaque psoriasis: Focus on patient selection and perspectives. Patient Preference and Adherence.

                                Centers for Disease Control and Prevention. (2025). Clinical overview of latent tuberculosis infection.

                                Kuwabara, T., et al. (2017). The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators of Inflammation.

                                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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