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Bijuva

Bijuva Side Effects

Cydnee Ng, PharmDKristianne Hannemann, PharmD
Reviewed by Cydnee Ng, PharmD, Kristianne Hannemann, PharmD
Last reviewed on February 27, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Breast tenderness (up to 10%)
  • Headache (up to 4%)
  • Nausea (up to 4%)
  • Vaginal discharge (up to 3%)
  • Vaginal bleeding (3%)
  • Pelvic pain (3%)

Less Common Side Effects

  • Stomach pain or discomfort
  • Nausea
  • Vomiting
  • Diarrhea
  • Swelling
  • Pain in arm or leg
  • Muscle spasms
  • Tiredness
  • Dizziness
  • Sleepiness
  • Trouble sleeping (insomnia)
  • Breast pain
  • Night sweats
  • Hot flush (hot flash)

Bijuva serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot in leg: leg pain or swelling, skin that's warm to the touch
  • Blood clot in lungs: trouble breathing, chest pain
  • Blood clot near the heart (heart attack): chest pain that travels to the arm, neck, or jaw; shortness of breath; cold sweat
  • Blood clot in the brain (stroke): sudden weakness on one side of the body, bad headache, changes in speech or vision, drooping face, confusion
  • Unusual changes in breast shape, size, or color
  • Unusual vaginal bleeding, vaginal discharge, or pelvic pain

Source: DailyMed

The following Bijuva side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
  • Change in vision such as blurry vision, seeing halos around lights, vision loss
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Heavy vaginal bleeding
  • Increase in blood pressure
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Swelling of the ankles, hands, or feet
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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