Bevyxxa (betrixaban) is an oral anticoagulant (blood thinner) that is used to prevent blood clots in people who have been hospitalized and are at risk for developing blood clots. It can raise your risk for serious life-threatening bleeding. Bevyxxa (betrixaban) was discontinued by the manufacturer in April 2020 due to business reasons.
Blood clot prevention in people who have been hospitalized
Bevyxxa (betrixaban) is an anticoagulant (blood thinner) that works by stopping factor Xa, a protein that’s involved in the blood clotting process. When this protein is blocked, blood clots are less likely to form in your body.
Source: FDA
Does not need routine blood monitoring like warfarin
Only needs to be taken once a day, whereas some other oral anticoagulants such as Eliquis (apixaban) are used twice daily
Available as an oral capsule, unlike other injectable anticoagulants, such as enoxaparin (Lovenox) or heparin
Available in 2 different strengths
Recently discontinued by the manufacturer in 2020
Can only be used for people who have been hospitalized
No generic available, so it is very expensive
Can cause you to bruise more easily. Minor cuts to the skin can take longer to stop bleeding.
No FDA approved way to quickly stop the effects of the medication in cases of a life-threatening bleed
Bevyxxa (betrixaban) makes blood clots less likely to form, which means it will make you bleed easier. Watch out for signs of bleeding like black, red, or tarry stools, vomiting blood, unexplained bruises or bruises that get bigger, or bleeding that won’t stop.
Let your provider know right away if you fall and hit your head, especially if you are dizzy or have a headache. This could be a sign of bleeding in your brain and needs to be addressed immediately.
If you are going to have surgery or a dental procedure, it is important to tell your provider that you are taking Bevyxxa (betrixaban). You might have to stop this medication a few days before your procedure to prevent a serious bleed during the procedure.
Bevyxxa (betrixaban) should be taken with food so that your body doesn’t absorb too much of the medication. This lowers the risk of serious side effects, such as life-threatening bleeding.
Bevyxxa (betrixaban) interacts with many common over-the-counter (OTC) products such as medications that are used for pain and herbal supplements. Talk to your provider or pharmacist before starting any new medications or supplements.
There is no FDA-approved way to reverse the effects of Bevyxxa (betrixaban) in an emergency bleeding situation. It is important that all of your providers or emergency personnel know you are taking this medication in case of an emergency.
It is important to take Bevyxxa (betrixaban) at the same time every day. If you forget to take a dose at your usual time, take the dose as soon as possible on the same day. Never take two doses to make up for a missed dose because it increases your risk of having a life-threatening bleed.
Bevyxxa (betrixaban) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Using other blood thinners or NSAIDs | History of spinal surgery or spinal tap | Use of in-dwelling epidural catheter | Anesthesia in the spine (epidural)
Taking Bevyxxa (betrixaban) puts you at a greater risk for bleeding around the spine, which can leave you paralyzed. This risk is even greater before a spinal surgery, including spinal taps or epidurals. If you are going to have a spinal tap or epidural, your provider will tell you how to safely stop Bevyxxa (betrixaban) before your procedure to lower the risk of a spinal bleed. Call your provider immediately if you notice any signs or symptoms of a spinal bleed, such as back pain, weakness, numbness, difficulty walking, or a loss of bowel or bladder control.
Risk factors: Taking other blood thinners or NSAIDs | Taking selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) | Severe kidney damage | Taking medications that are P-gp inhibitors
Taking Bevyxxa (betrixaban) puts you at risk of having a major life-threatening bleed. This risk is greater in people taking other medications that can also cause bleeding, such as: other blood thinners or NSAIDs like ibuprofen (Advil) or naproxen (Aleve); SSRIs, like escitalopram (Lexapro) or sertraline (Zoloft); and SNRIs like venlafaxine (Effexor).
Bleeding is more likely to happen in people with severe kidney damage, so the dose will be lowered to reduce the risk for bleeds. In addition, people taking medications that are considered to be P-glycoprotein inhibitors, such as azithromycin, clarithromycin, ketoconazole, amiodarone, and verapamil also start with a lower dose because they have a greater risk for bleeding. This is because these medications can raise the levels of Bevyxxa (betrixaban) in your body. Tell your provider immediately if you notice black, red, or tarry stools, blood in your vomit, unexplained bruises or bruises that get bigger, or bleeding that won’t stop.
People with APS are more likely to have recurrent blood clots when taking Bevyxxa (betrixaban) compared to people taking warfarin (Coumadin). This is especially true for people with triple-positive APS. Bevyxxa (betrixaban) should be avoided in people with APS to help prevent blood clots from occurring again.
Bevyxxa (betrixaban) is usually taken as a single dose of 160 mg by mouth, followed by 80 mg once daily for 35 to 42 days. It should be taken with food.
Your dose might be lower if you have kidney problems or are taking medications that are Pgp (P-glycoprotein) inhibitors, such as azithromycin (Zithromax), clarithromycin (Biaxin), ketoconazole, verapamil (Calan), and amiodarone.
Active bleeding
Lower the risk of stroke or blood clots in people with atrial fibrillation (AFib) not caused by a heart valve problem
Treat blood clots in the legs (deep vein thrombosis (DVT)) or lungs (pulmonary embolism (PE))
Lower the risk of DVT or PE coming back after treatment
Treat blood clots and lower the risk of new clots in children from birth and older
Lower the risk of stroke and blood clots in people with atrial fibrillation (AFib) not caused by a heart valve problem
Treat blood clots in the legs (deep vein thrombosis (DVT)) or lungs (pulmonary embolism (PE))
Lower the risk of DVT or PE coming back after treatment
Prevent blood clots in people in the hospital or recently released who are at high risk
Lower the risk of serious heart problems, like heart attack or stroke, in people with coronary artery disease (CAD), taken with aspirin
Lower the risk of blood clots and related problems in people with peripheral artery disease (PAD), taken with aspirin
Treat blood clots and lower the risk of new clots in children from birth to under 18 years old
Prevent blood clots in children 2 years and older with congenital heart disease (CHD) after a Fontan procedure
By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.