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Ayvakit Coupon - Ayvakit 25mg tablet

Ayvakit

avapritinib
Used for GIST, ISM, AdvSM
Used for GIST, ISM, AdvSM

Ayvakit (avapritinib) is a medication that’s FDA approved in adults to treat a certain type of cancer of the digestive system called gastrointestinal stromal tumor (GIST). It also treats adults with systemic mastocytosis, a blood cancer related to immune cells called mast cells. Ayvakit (avapritinib) is a type of targeted therapy called a tyrosine kinase inhibitor. It’s a tablet that’s taken by mouth once a day on an empty stomach. Common side effects include swelling, tiredness, and nausea. It can also cause changes in memory and attention.

Reviewed by:
reviewer
Julia Lee, PharmD, BCOP
reviewer
Cydnee Ng, PharmD
Last reviewed on November 13, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesImagesReferencesPricesMedicare
basics-icon

What is Ayvakit (avapritinib)?

What is Ayvakit (avapritinib) used for?

How Ayvakit (avapritinib) works

Ayvakit (avapritinib) is a tyrosine kinase inhibitor.

In the body, tyrosine kinases are proteins that help make sure cells grow and work normally. But in people with GIST or systemic mastocytosis, certain tyrosine kinases like PDGFRA and KIT can become overly active and cause cells to grow out of control.

Ayvakit (avapritinib) blocks the PDGFRA and KIT proteins. This helps slow down the condition’s growth.

Drug Facts

Common BrandsAyvakit
Drug ClassTyrosine kinase inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Ayvakit (avapritinib)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Indigestion
  • Constipation
  • Dizziness
  • Headache
  • Changes in taste
  • Sleep problems
  • Mood changes
  • Changes to hair
  • Trouble breathing
  • Weight loss
  • Rash
Note: Side effect percentages are from studies of people taking Ayvakit (avapritinib) for GIST. Side effects might differ for people with other types of cancer who take this medication.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Bleeding in the brain: very severe headache, nausea, vomiting, confusion, changes in vision

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding in the brain—severe headache, stiff neck, confusion, dizziness, change in vision, numbness or weakness of the face, arm, or leg, trouble speaking, trouble walking, vomiting
  • Difficulty with paying attention, memory, or speech
  • Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Diarrhea
  • Increased tears
  • Nausea
  • Skin reactions on sun-exposed areas
  • Stomach pain
  • Swelling of the ankles, hands, or feet
  • Unusual weakness or fatigue
pros-and-cons

Pros and cons of Ayvakit (avapritinib)

thumbs-up

Pros

A tablet that’s taken by mouth just once a day

Recommended option for people with GIST with specific mutations or people with certain types of systemic mastocytosis

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Cons

Must take on an empty stomach

Can cause problems with attention, thinking, and memory

pharmacist-tips

Pharmacist tips for Ayvakit (avapritinib)

pharmacist

  • Take Ayvakit (avapritinib) once a day on an empty stomach, at least 1 hour before or 2 hours after a meal.

    • Ayvakit (avapritinib) is available as 25 mg, 50 mg, 100 mg, 200 mg, and 300 mg tablets. You might need to take more than one tablet each time to make up your regular dose. Ask your oncologist or pharmacist if you have questions about your dose and how to take it.

      • If you miss a dose of Ayvakit (avapritinib) and it’s within 8 hours of your next dose, skip the dose you missed and take your next dose as usual. If you vomit after you take Ayvakit (avapritinib), there’s no need to take an extra dose to make up for it. Don’t double your dose because it can raise your risk for side effects.

        • Changes in memory, attention, or confusion are common side effects of Ayvakit (avapritinib). They’re usually mild and don’t typically affect people’s daily routines. If you notice these changes, avoid driving, operating heavy machinery, or doing anything that you need your complete attention for until you can check in with your oncology team. Also speak with them if these side effects get too troublesome.

          • Share your complete medication list, which should include over-the-counter products and supplements, with your oncology team. They can review your medications to check that they’re all safe for you to take. Ayvakit (avapritinib) can interact with other medications and supplements. These drug interactions can either make Ayvakit (avapritinib) work less well or raise your risk for side effects.

            • Keep Ayvakit (avapritinib) out of reach of visitors, children, or pets. Anticancer medications can be harmful to people who handle or come in contact with them.

              faqs

              Frequently asked questions about Ayvakit (avapritinib)

              Is Ayvakit (avapritinib) chemotherapy?
              No, Ayvakit (avapritinib) isn’t considered a traditional chemotherapy. Traditional chemotherapy are medications that damage and kill fast-growing cells. But Ayvakit (avapritinib) is a type of targeted therapy that works to prevent cell growth. It blocks certain proteins in the body that cause cells to divide uncontrollably.
              How do I know whether Ayvakit (avapritinib) is right for me?
              Talk with your oncologist if Ayvakit (avapritinib) would be a treatment option for you. Currently, this medication is FDA approved to treat certain people who have GIST that’s caused by specific gene changes (mutations). Your oncologist will collect a sample of your tumor (biopsy) and test it for a specific gene change in PDGFRA exon 18. If your GIST has this mutation, Ayvakit (avapritinib) might be a treatment option for you. It's also approved for treating indolent and advanced systemic mastocytosis. Discuss with your oncologist or specialist about available treatment options for your specific condition.
              How long do you take Ayvakit (avapritinib)?
              How long you take Ayvakit (avapritinib) will depend on why you’re taking the medication and how well it’s working for you. It also depends on how well you can tolerate the medication’s side effects or whether you have serious side effects from it. In clinical studies, the majority of people took Ayvakit (avapritinib) for at least 6 months. Talk with your oncologist about your specific treatment plan.
              Does Ayvakit (avapritinib) cause hair loss?
              In clinical studies, some people reported hair loss while they were taking Ayvakit (avapritinib). Usually, hair starts to grow back over several months after you stop treatment. Other people also noticed that their hair color changed. Speak with your oncology care team if you notice hair loss, hair thinning, or unusual hair changes while you’re taking Ayvakit (avapritinib). Your care team can recommend ways to help you manage this side effect.
              Is it safe to take Ayvakit (avapritinib) while pregnant?
              Based on how Ayvakit (avapritinib) works and on animal data, it’s possible that the medication can harm an unborn baby if it’s taken during pregnancy. For this reason, it’s important to prevent pregnancy during treatment if you’re sexually active. If you or your partner can become pregnant, use effective birth control while you’re taking Ayvakit (avapritinib) and for 6 weeks after your last dose.
              Can you breastfeed while you’re taking Ayvakit (avapritinib)?
              Avoid breastfeeding while you’re taking Ayvakit (avapritinib) and for 2 weeks after stopping the medication. Although we don’t know whether Ayvakit (avapritinib) can get into breast milk, there’s a risk that it does and that it can harm breastfeeding infants. Speak with your oncology care team or obstetrician-gynecologist (OB-GYN) about safer alternatives to breastfeeding, like using baby formula.
              Can Ayvakit (avapritinib) affect fertility?
              Based on studies done in animals, Ayvakit (avapritinib) might affect fertility, or the ability to have children at doses of 200 mg or higher. Before you start taking Ayvakit (avapritinib), talk with your oncologist or care team about resources for family planning if you’re considering becoming pregnant or fathering a child.
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              What are the risks and warnings for Ayvakit (avapritinib)?

              Ayvakit (avapritinib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Bleeding in the brain

              • Risk factors: History of swollen or ruptured blood vessels (aneurysms) | Previous stroke or brain bleeds within the past year | Taking blood thinners | Low platelet levels

                Bleeding in the brain is a rare but serious side effect of Ayvakit (avapritinib). Make sure to share your complete medical history and medication list with your oncology care team. Previous strokes, brain bleeds, or swollen or ruptured blood vessels (aneurysms) and treatment with blood thinners can raise your risk of having bleeding in the brain while you’re taking Ayvakit (avapritinib).

                If you’re taking Ayvakit (avapritinib) for advanced systemic mastocytosis, you’ll need to have your blood drawn to check your platelet levels before you start treatment. You’ll also get them checked every 2 to 4 weeks while you’re taking the medication. Having low platelet levels can put you at risk for bleeding in the brain. If your platelet levels get too low, your oncologist will stop your Ayvakit (avapritinib) treatment for a while and restart it at a lower dose once your platelet levels normalize.

                Get medical help right away if you develop any symptoms of a brain bleed, such as a severe headache, confusion, nausea, repeated vomiting, or changes in vision, while you’re taking Ayvakit (avapritinib). You’ll have to stop taking the medication if you have a brain bleed during treatment.

                risk-warning

                Side effects affecting the nervous system

                • Risk factors: High Ayvakit (avapritinib) dose | Older age

                  People who take Ayvakit (avapritinib) can have a variety of side effects affecting the nervous system. These side effects can include confusion, forgetfulness, and speaking problems.

                  During clinical studies, these side effects were more common in people who took high doses of Ayvakit (avapritinib). Some people noticed these side effects within 2 to 4 months (and sometimes as early as a day) of starting the medication. Usually, the symptoms went away about 2 months after lowering the dose, pausing, or stopping treatment.

                  Let your healthcare team know if you have any new or worsening drowsiness, forgetfulness, problems concentrating, or problems with speaking while you’re taking Ayvakit (avapritinib). Avoid driving or doing anything that you need to concentrate on until a healthcare professional examines you. You might need to take a break from Ayvakit (avapritinib) so that you can recover from these side effects. Once your symptoms improve, you might be able to restart Ayvakit (avapritinib) at a lower dose.

                  risk-warning

                  Harm to an unborn baby

                  Based on findings from animal studies, it’s possible for Ayvakit (avapritinib) to harm to an unborn baby if it’s taken during pregnancy. You might need to take a pregnancy test before starting treatment to make sure you’re not pregnant. Use effective birth control, such as birth control pills or condoms, while you’re taking Ayvakit (avapritinib) and for at least 6 weeks after your last dose if you’re sexually active. Let your oncologist know if you or your partner gets pregnant or plans to become pregnant while you’re taking Ayvakit (avapritinib).

                  dosage

                  Ayvakit (avapritinib) dosage forms

                  Typical dosing for Ayvakit (avapritinib)

                  • Gastrointestinal stromal tumor (GIST) with PDGFRA mutations: The typical dose is 300 mg by mouth once daily.

                  • Indolent systemic mastocytosis: The typical dose is 25 mg by mouth once daily.

                  • Advanced systemic mastocytosis: The typical dose is 200 mg by mouth once daily.

                  Your oncologist might lower your dose if you have side effects from the medication (e.g., nausea, abnormal blood test results). They might also lower your dose if you have severe liver problems.

                  alternatives

                  What are alternatives to Ayvakit (avapritinib)?

                  There are a number of medications that your doctor can prescribe in place of Ayvakit (avapritinib). Compare a few possible alternatives below.
                  Ayvakit (avapritinib)
                  Used for:
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                  Rydapt (midostaurin)
                  Used for:
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                  Imatinib (Gleevec)
                  Used for:

                  • Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)

                  • Ph+ acute lymphoblastic leukemia (Ph+ ALL)

                  • Myelodysplastic or myeloproliferative diseases (MDS/MPD)

                  • Aggressive systemic mastocytosis (ASM)

                  • Hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia (CEL)

                  • Dermatofibrosarcoma protuberans (DFSP)

                  • Gastrointestinal stromal tumors (GIST)

                  $44.00 Lowest GoodRx priceView Prices
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                  Ayvakit (avapritinib) images

                  White Round Blu And 25 - AYVAKIT 25mg Tablet
                  This medicine is White, Round Tablet Imprinted With "Blu" And "25".White Round Blu And 25 - AYVAKIT 25mg Tablet

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                  References

                  Best studies we found

                  American Academy of Allergy, Asthma & Immunology. (2024). Systemic mastocytosis.

                  American Cancer Society. (2019). Chemotherapy safety.

                  American Cancer Society. (2019). Tests for gastrointestinal stromal tumors.

                  View All References (16)

                  American Cancer Society. (2019). What are gastrointestinal stromal tumors?

                  Belum, V. R., et al. (2015). Alopecia in patients treated with molecularly targeted anticancer therapies. Annals of Oncology.

                  Blueprint Medicines Corporation. (2024). Ayvakit- avapritinib tablet, film coated [package insert]. DailyMed.

                  Centers for Disease Control and Prevention. (2024). Facts about ultraviolet radiation.

                  Joseph, C. P., et al. (2021). Optimal avapritinib treatment strategies for patients with metastatic or unresectable gastrointestinal stromal tumors. The Oncologist.

                  Leukemia & Lymphoma Society. (2022). Mastocytosis.

                  MedlinePlus. (2021). KIT gene.

                  MedlinePlus. (2021). PDGFRA gene.

                  MedlinePlus. (2023). Platelet count.

                  MedlinePlus. (2024). Hemoglobin.

                  National Cancer Institute. (2020). Avapritinib approved to treat GIST with a rare gene alteration.

                  National Cancer Institute. (2022). Targeted therapy to treat cancer.

                  National Comprehensive Cancer Network. (2022). Systemic mastocytosis.

                  National Comprehensive Cancer Network. (2023). Gastrointestinal stromal tumors (GIST).

                  Sun, Y., et al. (2022). An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors. Frontiers in Oncology.

                  U.S. Food and Drug Administration. (2024). The sun and your medicine.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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