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Ayvakit

Avapritinib

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About Ayvakit

The average list price of Ayvakit (Avapritinib) is $38,929.00, but your out of pocket cost will likely be less if you have insurance. Ayvakit is covered by some Medicare and insurance plans. This drug is also a limited distribution drug, meaning it is not available at retail pharmacies. Refer to the Key Takeaways for additional information on Ayvakit and check our savings tips for other ways to reduce your cost. A generic version of Ayvakit is not yet available.

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Ayvakit Savings Card

Pay as little as

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Get treatment support for AYVAKIT® (avapritinib)

For patients prescribed AYVAKIT, YourBlueprint® provides personalized support for every step of the treatment journey.

Financial Assistance: With YourBlueprint, you may be eligible for our financial assistance programs if you don’t have insurance, coverage is limited, or your out-of-pocket costs are unaffordable.**
Co-Pay Assistance Program: If you’re an eligible patient, you could receive coverage on your co-pay, co-insurance or deductible expenses, paying as little as $0* per month.
1-on-1 Support: Through a dedicated Case Manager, you can get help navigating insurance coverage, financial support options and AYVAKIT access.

*Up to an annual maximum benefit of $25,000. Terms and conditions apply.

**Additional terms and conditions may apply.

Full Prescribing Information Patient Information

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INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS AYVAKIT® (avapritinib)?
AYVAKIT® (avapritinib) is a prescription medicine used to treat adults with indolent systemic mastocytosis (ISM). AYVAKIT is not recommended in people with low platelet counts (less than 50 X 10^9/L). It is not known if AYVAKIT is safe and effective in children.

IMPORTANT SAFETY INFORMATION
AYVAKIT® (avapritinib) may cause serious side effects, including:

Cognitive effects. Cognitive side effects can happen during treatment with AYVAKIT and can be severe. Tell your healthcare provider if you develop any new or worsening cognitive symptoms including forgetfulness, confusion, getting lost, trouble thinking, drowsiness, trouble staying awake (somnolence), word finding problems, seeing objects or hearing things that are not there (hallucinations), or a change in mood or behavior.

Skin sensitivity to sunlight (photosensitivity). Your skin may be sensitive to the sun or other forms of light (photosensitivity) during treatment with AYVAKIT. Avoid or limit exposure to direct sunlight, sunlamps, and other sources of ultraviolet radiation during treatment and for 1 week after stopping treatment with AYVAKIT. Use sunscreen or wear clothes that cover your skin if you need to be out in the sun.

Before taking AYVAKIT, tell your healthcare provider about all of your medical conditions, including if you:
• history of bulging or weakening of a blood vessel wall (aneurysm) or bleeding in your brain
• have a history of stroke within the last year
• have low platelet counts
• have or have had liver problems
• are pregnant or plan to become pregnant. AYVAKIT can cause harm to your unborn baby
◦Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start AYVAKIT. You should use effective birth control (contraception) during treatment with AYVAKIT and for 6 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with AYVAKIT.
◦Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 6 weeks after the final dose of AYVAKIT.
• are breastfeeding or plan to breastfeed. It is not known if AYVAKIT passes into your breast milk. Do not breastfeed during treatment with AYVAKIT and for at least 2 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. AYVAKIT may affect the way other medicines work, and certain other medicines may affect how AYVAKIT works. Especially tell your healthcare provider if you take estrogen-containing hormonal birth control or medicines that prevent blood clots.

Do not drive or operate hazardous machinery if you have confusion or trouble thinking during treatment with AYVAKIT.

The most common side effects of AYVAKIT in people with ISM include: swelling around your eyes, dizziness, swelling of your arms and legs, and flushing.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with AYVAKIT if you develop certain side effects. AYVAKIT may cause fertility problems in females and males. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of AYVAKIT. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here to see the full Prescribing Information and Patient Information for AYVAKIT.