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Tretinoin Coupon - Tretinoin 45g of 0.05% tube of gel

Atralin

tretinoin
Used for Acne

Atralin (tretinoin) is a prescription topical retinoid used to treat acne in adults and children 10 years and older. It comes as a gel that's applied to affected areas of the skin once a day. Common side effects include dry skin, peeling or flaking, burning, and redness.

Reviewed by:Last reviewed on October 19, 2026
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What is Atralin (tretinoin)?

What is Atralin (tretinoin) used for?

How Atralin (tretinoin) works

Atralin (tretinoin) is a retinoid, which is a form of vitamin A. The exact way it treats acne isn't fully understood, but it helps prevent dead skin cells from sticking together and clogging your pores. This helps clear existing clogged pores and prevent new acne from forming.

When does Atralin (tretinoin) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Initial effect
MONTHS
Full effect

Drug facts

Common BrandsAtralin
Drug ClassRetinoid
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Atralin (tretinoin)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry skin (16%)
  • Peeling, scaling, or flaking skin (12%)
  • Skin burning sensation (8%)
  • Skin redness (7%)
  • Itchy skin (2%)

Less Common Side Effects

  • Skin pain
  • Sunburn
  • Changes in skin color

Atralin (tretinoin) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: hives, severe itching, swelling, trouble breathing

Source: DailyMed

The following Atralin (tretinoin) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning, stinging, peeling, redness, or unusual dryness of the skin (severe)

Less common

Dryness, pain, redness, irritation, or peeling at the application site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, itching, stinging, scaling, or redness of the skin

chapping or slight peeling of the skin (mild)

darkening of the skin

lightening of normal skin color

lightening of treated areas of dark skin

redness of skin (mild)

unusual dryness of skin (mild)

unusually warm skin (mild)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Atralin (tretinoin)

Pros

  • Only applied once daily
  • Gel formulation designed to reduce skin irritation
  • Approved for adults and children ages 10 years and older

Cons

  • Acne can take several weeks to improve
  • Can make your skin more sensitive to sunlight
  • Might not be the best option for people with fish allergies
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Pharmacist tips for Atralin (tretinoin)

pharmacist
  • Apply Atralin (tretinoin) once a day in the evening before bedtime. Acne treatments take time to work, so use it regularly even if you don't see improvement right away.
  • Atralin (tretinoin) can cause dryness, redness, pain, and peeling, and your acne might temporarily get worse at first. A moisturizer can help with dryness. Contact your prescriber if irritation is severe or doesn't improve.
  • Atralin (tretinoin) can make your skin more sensitive to sunlight. Avoid tanning beds and sunlamps, and wear sunscreen and protective clothing when you're outside.
  • You can wear makeup while using Atralin (tretinoin). Make sure to remove it and gently clean your skin before applying the medication.
  • Cold weather, wind, and certain skin products can cause more irritation while you're using Atralin (tretinoin). If your skin becomes irritated, let it recover before applying the medication again.
  • Pregnancy: Atralin (tretinoin) generally isn't recommended during pregnancy. Talk to a healthcare professional about the risks and benefits if you're pregnant or planning to become pregnant.
  • Breastfeeding: Only a small amount of Atralin (tretinoin) is expected to enter your body through your skin, so it's considered low risk while breastfeeding. Talk to your prescriber before using it while breastfeeding.

How to use Atralin (tretinoin)

  • Before you apply the gel, gently wash your skin with a mild cleanser and pat it dry.
  • Apply a thin layer to the affected skin and gently rub it in.
  • Wash your hands after applying the gel, unless your hands are the area being treated. This helps prevent accidentally getting the medication in your eyes or other sensitive areas.
  • Don't apply the gel to broken, sunburned, or eczema-affected skin. These areas can become more irritated.
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Risks and warnings for Atralin (tretinoin)

Atralin (tretinoin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Skin irritation

  • Risk factors: Sunburned or irritated skin | Eczema | Washing or scrubbing your skin too often | Contact with lime peels

Atralin (tretinoin) can cause dryness, redness, peeling, or irritation where you apply it. To help prevent irritation, wash your skin gently with a mild cleanser, avoid scrubbing or washing too often, and use a moisturizer if needed. Also avoid contact with lime peels, which can irritate your skin.

Tell your care team if your skin becomes very irritated. They might recommend using less medication, applying it less often, pausing treatment, or stopping it.

Sun sensitivity

  • Risk factors: Spending a lot of time in the sun | Having skin that's sensitive to sunlight | Using sunlamps or tanning beds | Cold or windy weather

Atralin (tretinoin) can make your skin more sensitive to sunlight and more likely to become irritated from cold or windy weather. Limit time in the sun and avoid sunlamps and tanning beds. When you're outside, use sunscreen with at least SPF 15 and wear protective clothing over treated skin.

Use with caution in people with fish allergies

  • Risk factors: Allergy to fish or fish-containing products

Atralin (tretinoin) contains fish proteins, which might cause an allergic reaction if you have a fish allergy. Tell your care team about any fish allergies before starting treatment. Contact them if you develop itching or hives after using the medication.

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Atralin (tretinoin) dosage

The average cost for 1 tube of 45g of 0.05% of Atralin (tretinoin) is $101.78 with a free GoodRx coupon. This is 42.81% off the average retail price of $177.96.
tube of gelTube of gel
DosageQuantityPrice as low asPrice per unit
45g of 0.05%1 tube$101.78$101.78
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Interactions between Atralin (tretinoin) and other drugs

Atralin (tretinoin) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Atralin (tretinoin). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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How much does Atralin (tretinoin) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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What are alternatives to Atralin (tretinoin)?

There are a number of medications that your doctor can prescribe in place of Atralin (tretinoin). Compare a few possible alternatives below.
Atralin (tretinoin)
Used for:
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Used for:
  • Acne
$10.09Lowest GoodRx priceView prices
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  • Treatment of papules and pustules in adults with mild-to-moderate rosacea
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News about Atralin (tretinoin)

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Atralin (tretinoin) images

Not applicable - Tretinoin 0.025% Topical Gel
This medicine is Colorless Tube Of Gel.Not applicable - Tretinoin 0.025% Topical Gel
Yellow Not applicable - Tretinoin 0.05% Topical Gel
This medicine is Yellow Tube Of Gel.Yellow Not applicable - Tretinoin 0.05% Topical Gel

References

Best studies we found

Bausch Health US. (2024). ATRALIN (tretinoin) gel, 0.05% [package insert]. DailyMed.

Del Rosso, J. Q., et al. (2010). Absence of degradation of tretinoin when benzoyl peroxide is combined with an optimized formulation of tretinoin gel (0.05%). The Journal of Clinical and Aesthetic Dermatology.

Drugs and Lactation Database (LactMed). (n.d.). Tretinoin.

Journal of Drugs in Dermatology. (2012). Pipeline previews.

MotherToBaby. (2024). Topical tretinoin.

Rusu, A., et al. (2020). Recent advances regarding the therapeutic potential of adapalene. Pharmaceuticals.

U.S. Food and Drug Administration. (2018). Multi-disciplinary review and evaluation: ALTRENO (tretinoin) lotion, 0.05% for topical use.

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