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Naproxen Sodium Coupon - Naproxen Sodium 550mg tablet

naproxen sodium

Generic Anaprox DS
Used for Rheumatoid Arthritis, Osteoarthritis, Gout, Pain, Menstrual Pain
Used for Rheumatoid Arthritis, Osteoarthritis, Gout, Pain, Menstrual Pain

Prescription-strength naproxen sodium (Anaprox DS) is a non-steroidal anti-inflammatory drug (NSAID). It relieves pain and inflammation in children and adults by blocking specific proteins called cyclooxygenases. This medication is prescribed to treat certain conditions, such as rheumatoid arthritis and menstrual cramps. Naproxen sodium (Anaprox DS) is the sodium salt form of naproxen, and is absorbed more quickly into the body than naproxen. It comes as a tablet that's taken by mouth, typically 2 to 3 times daily. Some common side effects include stomach upset and dizziness.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Connie Zheng, PharmD
Last reviewed on May 14, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Naproxen sodium (Anaprox DS)?

What is Naproxen sodium (Anaprox DS) used for?

How Naproxen sodium (Anaprox DS) works

Naproxen sodium (Anaprox DS) is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking proteins (called cyclooxygenase, or COX) in your body that cause inflammation, pain, and swelling.

Are you looking for information on over-the-counter naproxen (Aleve) or naproxen (Naprosyn) instead?
When does Naproxen sodium (Anaprox DS) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsAnaprox DS
Drug ClassNSAID
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Naproxen sodium (Anaprox DS) essentials

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What are the side effects of Naproxen sodium (Anaprox DS)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The following side effects were reported in up to 10% of people in clinical studies:
  • Heartburn
  • Stomach pain
  • Constipation
  • Nausea
  • Dizziness
  • Drowsiness
  • Headache
  • Itchy skin
  • Bruising
  • Ringing in the ears
  • Swelling
  • Shortness of breath

Other Side Effects

  • Indigestion
  • Diarrhea
  • Sweating
  • Mouth sores
  • Racing heart
  • Spinning sensation
  • Being more thirsty than usual
  • Changes in hearing

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, slurred speech
  • Heart failure: difficulty breathing, swelling, fast heartbeat
  • Dangerously high blood pressure: headache, shortness of breath, changes in vision, light-headedness, fatigue
  • Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
  • Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing
  • Serious skin reaction: skin reddening, blisters, rash
When do Naproxen sodium (Anaprox DS) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Stomach pain
Heartburn
Nausea
Risk of stomach ulcers / bleeding
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Naproxen sodium (Anaprox DS) side effects

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The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Increase in blood pressure
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Round red or dark patches on the skin that may itch, burn, and blister
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Naproxen sodium (Anaprox DS)

thumbs-up

Pros

Taken by mouth

Sodium salt form of naproxen; might relieve pain more quickly than naproxen (Naprosyn)

Effect lasts longer than some other NSAIDs, such as ibuprofen (Advil)

thumbs-down

Cons

Only available as a tablet, not a good choice for people who have trouble swallowing tablets

Not a good option for children under 50 kg (110 lbs)

Can't take during pregnancy

pharmacist-tips

Pharmacist tips for Naproxen sodium (Anaprox DS)

pharmacist

  • You might start to feel the pain-relieving effects of naproxen sodium (Anaprox DS) within a few hours. But if you're taking naproxen sodium (Anaprox DS) for inflammation, it can take several weeks before the swelling goes down. Depending on what you're taking naproxen sodium (Anaprox DS) for, you might need to continue treatment for a while before you know whether this medication is helping or not.

    • Naproxen sodium (Anaprox DS) raises the risk of stomach bleeding. Tell your prescriber right away if you experience unexplained vomiting or stomach pain, or blood in your vomit or stool. They can let you know if you need more medical attention.

      • It's best to avoid drinking alcohol while taking naproxen sodium (Anaprox DS). Doing so can raise your risk for stomach bleeding and other stomach-related side effects. If you drink alcohol regularly and it's difficult for you to stop, talk with your healthcare team. They can recommend resources to help you stop drinking, or they can discuss other alternative options to help with your condition.

        • Never take naproxen sodium (Anaprox DS) with other NSAIDs, such as ibuprofen (Motrin, Advil). Doing so puts you at higher risk for stomach bleeds, stroke, and heart attack. Make sure to carefully check the manufacturer's label for over-the-counter pain and cold medications because they might contain NSAIDs. Ask a healthcare professional if you're not sure whether you're already taking a medication with an NSAID.

          • If you're taking aspirin for your heart, make sure to ask your prescriber if it's safe for you to also take naproxen sodium (Anaprox DS). Taking both medications together raises your risk for side effects.

            • If you're pregnant, talk to your healthcare team about safer alternatives than naproxen sodium (Anaprox DS) for pain. You should avoid taking naproxen sodium (Anaprox DS) during the second half of pregnancy because it might cause problems to your unborn baby or cause complications during delivery. And the safety of naproxen sodium (Anaprox DS) in the first half of pregnancy isn't clear.

              • If you're breastfeeding, discuss with your healthcare team about the risks and benefits of taking naproxen sodium (Anaprox DS). Limited research shows that naproxen sodium (Anaprox DS) can get into breastmilk. This means there might be a small risk of harm to the breastfed baby.

                faqs

                Frequently asked questions about Naproxen sodium (Anaprox DS)

                Is naproxen sodium (Anaprox DS) a narcotic?
                No, naproxen sodium (Anaprox DS) isn't a narcotic because it's not an opioid pain medication. Naproxen sodium (Anaprox DS) is a non-steroidal anti-inflammatory drug (NSAID).
                Can you take acetaminophen (Tylenol) with naproxen sodium (Anaprox DS)?
                Acetaminophen (Tylenol) doesn't have any known interactions with naproxen sodium (Anaprox DS). Sometimes, HCPs might prescribe both medications together for people who need additional pain relief. But acetaminophen (Tylenol) might not be a good add-on option for everyone because this medication can raise the risk for liver damage. Check with your healthcare team to see if you can take acetaminophen (Tylenol) with naproxen sodium (Anaprox DS).
                Does naproxen sodium (Anaprox DS) make you sleepy?
                Yes, naproxen sodium (Anaprox DS) can make you sleepy. In clinical studies, up to 9% of people taking naproxen reported sleepiness. Pay attention to how naproxen sodium (Anaprox DS) is affecting your sleep. If you feel too sleepy to go about your day, contact your prescriber. They can check to see if the sleepiness is caused by naproxen sodium (Anaprox DS) or other factors. If needed, they can recommend an alternative medication to help with your symptoms.
                Does naproxen sodium (Anaprox DS) raise blood pressure?
                Yes, it's possible for naproxen sodium (Anaprox DS) to potentially raise your blood pressure. This medication might not be the best choice if you already have high blood pressure or if you're taking blood pressure medications. If your healthcare provider decides to prescribe naproxen sodium (Anaprox DS), they might ask you to check your blood pressure regularly at home to see how the medication might be affecting your blood pressure. It's best to write down your blood pressure numbers in a journal and bring it to your appointments with your cardiologist or primary care provider. Let them know if you notice any changes in your blood pressure after starting this medication.
                Is Anaprox DS the same as naproxen?
                Anaprox DS is a prescription-strength medication that contains the sodium salt form of naproxen. Evidence suggests the body might absorb naproxen sodium (Anaprox DS) more quickly than naproxen (Naprosyn). Because of this, healthcare professionals (HCPs) might prescribe naproxen sodium (Anaprox DS) over naproxen (Naprosyn) for more acute pain, such as menstrual cramps or pain from a gout attack. Talk with your healthcare team if you've more questions about the different forms of naproxen.
                Is Anaprox over the counter?
                No, naproxen sodium (Anaprox DS) isn't over-the-counter, it's a prescription-strength brand of naproxen. But there is an over-the-counter (OTC) form, naproxen (Aleve), that's commonly found in most retail pharmacies.
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                What are the risks and warnings for Naproxen sodium (Anaprox DS)?

                Naproxen sodium (Anaprox DS) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Stomach bleeding

                • Risk factors: Older adult | History of stomach bleeding or bleeding problems | Liver problems | Taking other medications that raise your risk of bleeds | Drinking alcohol | Smoking | Taking naproxen sodium (Anaprox DS) for a long time

                  Naproxen sodium (Anaprox DS), like all NSAIDS, raises your risk for stomach ulcers (sores) and bleeds. Stomach bleeding can happen at anytime during treatment; it's a dangerous side effect that requires treatment right away. Often times, people who have stomach bleeds don't experience any symptoms. Make sure to tell your healthcare professional (HCP) or pharmacist about all of your conditions and medications before starting naproxen sodium (Anaprox DS) so they can talk with you about your risk for stomach bleeding. If you're feeling faint, vomiting blood, have bloody or dark stools, or have severe stomach pain or discomfort that doesn't go away while taking naproxen sodium (Anaprox DS), seek medical attention right away.

                  risk-warning

                  Heart attack and stroke

                  • Risk factors: Heart problems | Taking higher doses of naproxen sodium (Anaprox DS) | Taking naproxen sodium (Anaprox DS) for a long time | Past or planned heart surgery

                    Naproxen sodium (Anaprox DS) might raise your risk of having blood clots, which can cause a heart attack or stroke. To lower your risk of blood clots and heart problems, your HCP will prescribe naproxen sodium (Anaprox DS) for the shortest time needed to treat your condition. If you have heart problems, talk to your HCP before starting this medication. Don't take naproxen sodium (Anaprox DS) if you had, or will have, heart surgery. Call 911 or get immediate help if you experience chest pain, shortness of breath, weakness on one side of your body, or trouble speaking or walking.

                    risk-warning

                    High blood pressure and heart failure

                    • Risk factors: Heart problems

                      Naproxen sodium (Anaprox DS) can cause your body to hold onto extra fluid, which can raise your blood pressure or put you at risk for heart failure. Tell your HCP if you have a history of heart problems, or are taking blood pressure medications, before starting naproxen sodium (Anaprox DS) to make sure it's safe for you. Your HCP will screen you for heart problems before starting you on this medication. Some forms of naproxen sodium (Anaprox DS) contains sodium, so it's important to keep track of how much you're getting from your doses if you're on a low-salt diet. If you experience unexplained fainting, chest pain with physical activity, or irregular heartbeat while taking naproxen sodium (Anaprox DS), contact your HCP.

                      risk-warning

                      Kidney damage

                      • Risk factors: Older adult | Kidney problems | Heart failure | Liver problems | High blood sugar levels | Not enough fluids in the body (dehydration) | Taking other medications that can cause kidney problems

                        Naproxen sodium (Anaprox DS) can cause kidney problems. Your risk is higher if you have certain factors like older age, certain medical problems like diabetes, or you're taking medications that can cause kidney problems. Your healthcare professional might order lab tests to monitor your kidney health before and during treatment with naproxen sodium (Anaprox DS). If your kidney health worsens, your HCP might stop your naproxen sodium (Anaprox DS) treatment. Contact your HCP if you develop any signs or symptoms of kidney failure, including changes in your need to urinate, tiredness, dry and itchy skin, low appetite, and muscle cramps.

                        risk-warning

                        Liver problems

                        • Risk factors: History of liver problems

                          Though rare, naproxen sodium (Anaprox DS) can cause serious liver problems that can lead to liver failure. Get medical attention right away if you notice swelling of your stomach, stomach pain, yellowing of your skin or the whites of your eyes, stool changes (black, tarry, or bloody stools), nausea, vomiting, confusion, or dark or brown urine. You might need to stop using the medication to prevent further liver damage.

                          risk-warning

                          Severe allergic reactions

                          • Risk factors: Aspirin allergy | NSAID allergy

                            Severe allergic reactions to naproxen sodium (Anaprox DS) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis. Let your HCP know if you have an allergy to aspirin or other NSAIDs before starting naproxen sodium (Anaprox DS). If you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using naproxen sodium (Anaprox DS), get medical attention right away.

                            Although rare, naproxen sodium (Anaprox DS) can cause serious skin reactions called Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS). If you notice changes in your skin, such as rash, blisters, skin reddening, or skin peeling, stop using naproxen sodium (Anaprox DS) and get medical attention right away.

                            risk-warning

                            Not for use while pregnant or breastfeeding

                            Naproxen sodium (Anaprox DS) can cause harm to your unborn baby, especially if it's taken in the second half of pregnancy (after week 20). It can cause serious complications, such as heart or kidney problems in your unborn baby or problems during delivery. Speak to your HCP about the risks and benefits of taking naproxen sodium (Anaprox DS) if you're pregnant before taking this medication. Ask whether there are safer alternatives.

                            dosage

                            Naproxen sodium (Anaprox DS) dosage forms

                            The average cost for 20 tablets of 550mg of Naproxen sodium (Anaprox DS) is $10.00 with a free GoodRx coupon. This is 81.43% off the average retail price of $53.86.
                            tablet
                            Tablet
                            DosageQuantityPrice as low asPrice per unit
                            275mg20 tablets$17.09$0.85
                            550mg20 tablets$10.00$0.50

                            Typical dosing for Naproxen sodium (Anaprox DS)

                            The different strengths and formulations of naproxen aren't interchangeable. Your healthcare team will likely need to adjust your dose if they're switching you from one form of naproxen to another.

                            • RA, OA, and AS: The typical dose is from 275 mg or 550 mg by mouth twice per day. The maximum daily dose is 1,650 mg.

                            • Juvenile idiopathic arthritis (A naproxen liquid suspension (e.g., Naproxen (Naprosyn) suspension) is preferred for children. The tablet should only be taken by children who weigh more than 50 kg): Your child's pediatrician will determine the dose based on your child's body weight. The typical dose is 5 mg/kg by mouth twice daily.

                            • Pain, menstrual cramps, tendonitis, and bursitis: The typical dose is a single dose of 550 mg by mouth, followed by 550 mg by mouth every 12 hours or 275 mg every 6 to 8 hours as needed. The maximum dose is 1,100 mg per day or as directed by your healthcare team.

                            • Gout: The typical dose is 825 mg by mouth at the start of a gout attack, then 275 mg every 8 hours until your symptoms go away.

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                            interactions

                            Interactions between Naproxen sodium (Anaprox DS) and other drugs

                            Naproxen sodium (Anaprox DS) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Naproxen sodium (Anaprox DS). Please note that only the generic name of each medication is listed below.

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                            Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                            How much does Naproxen sodium (Anaprox DS) cost?

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                            contraindications-icon

                            Naproxen sodium (Anaprox DS) contraindications

                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Naproxen sodium (Anaprox DS) will not be safe for you to take.
                            alternatives

                            What are alternatives to Naproxen sodium (Anaprox DS)?

                            There are a number of medications that your doctor can prescribe in place of Naproxen sodium (Anaprox DS). Compare a few possible alternatives below.
                            Naproxen sodium (Anaprox DS)
                            Used for:
                            $10.00 Lowest GoodRx priceView Prices
                            Diclofenac
                            Used for:

                            • Mild to moderate pain

                            • Osteoarthritis

                            • Rheumatoid arthritis

                            • Ankylosing spondylitis (arthritis of the spine)

                            • Migraine attacks

                            • Menstrual cramps

                            $13.20 Lowest GoodRx priceView Prices
                            Ibuprofen
                            Used for:
                            $8.92 Lowest GoodRx priceView Prices
                            images

                            Naproxen sodium (Anaprox DS) images

                            Blue Oblong Nps 550 - Naproxen Sodium DS 550mg Tablet
                            This medicine is Blue, Oblong, Scored Tablet Imprinted With "Nps 550".Blue Oblong Nps 550 - Naproxen Sodium DS 550mg Tablet

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                            References

                            Best studies we found

                            Aurobindo Pharma Limited. (2021). Naproxen sodium - naproxen sodium tablet, film coated [package insert]. DailyMed.

                            Department of Justice/Drug Enforcement Administration. (2020). Narcotics.

                            Drugs and Lactation Database (LactMed®). (2024). Naproxen. National Institute of Child Health and Human Development.

                            View All References (4)

                            Moyer, S. (1986). 9: Pharmacokinetics of naproxen sodium. Cephalagia.

                            National Heart, Lung, and Blood Institute. (2022). What is coronary artery bypass grafting?

                            National Kidney Foundation. (2020). 10 signs you may have kidney disease.

                            U.S. Food and Drug Administration. (2022). FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid: FDA Drug Safety Podcast.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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