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Spironolactone / HCTZ Coupon - Spironolactone / HCTZ 25mg/25mg tablet

spironolactone / HCTZ

Generic Aldactazide
Used for Kidney Disease, Heart Failure, Hypertension, Cirrhosis
Used for Kidney Disease, Heart Failure, Hypertension, Cirrhosis

Aldactazide is a combination medication containing spironolactone, a potassium-sparing diuretic, and hydrochlorothiazide, a loop diuretic. This combination water pill treats high blood pressure (hypertension). It also helps lessen fluid buildup throughout the body from liver, kidney, or heart problems. This medication is a tablet that's taken by mouth. Side effects include frequent urination, stomach upset, and dizziness. It's available in a brand-name and generic version.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on November 5, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Aldactazide (spironolactone / hydrochlorothiazide)?

What is Aldactazide (spironolactone / hydrochlorothiazide) used for?

How Aldactazide (spironolactone / hydrochlorothiazide) works

Aldactazide is a combination of two different diuretics (or water pills). Spironolactone is a potassium-sparing diuretic and hydrochlorothiazide is a thiazide diuretic. They both work in the kidneys to help remove extra water from your body. This lowers blood pressure and lessens water retention (swelling).

Spironolactone also helps restore potassium in the body that's lost as a side effect of hydrochlorothiazide. The addition of spironolactone helps prevent low potassium levels that can possibly happen with hydrochlorothiazide.

Are you looking for information on spironolactone (Aldactone) or hydrochlorothiazide instead?

Drug Facts

Common BrandsAldactazide
Drug ClassDiuretic (water pill)
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Aldactazide (spironolactone / hydrochlorothiazide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Common hydrochlorothiazide side effects:
  • Weakness
  • Low blood pressure
  • Diarrhea
  • Vomiting
  • Low electrolyte levels (e.g., calcium, magnesium, sodium)
Common spironolactone side effects:

Other Side Effects

  • Difficulty getting or maintaining an erection
  • Low sex drive
  • Irregular or no menstrual periods
  • Leg cramps
  • Dehydration

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction or skin reaction: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
  • High potassium levels: nausea, muscle weakness, tingling, abnormal heartbeat
  • Abnormal levels of other electrolytes: muscle cramps, fainting, irregular heartbeat, seizure

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Back or leg pains

blistering, peeling, or loosening of the skin

bloody or black, tarry stools

bloody or cloudy urine

blue lips and fingernails

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or tightness

clay-colored stools

clear or bloody discharge from the nipple

confusion

cough or hoarseness

dark urine

decreased appetite

diarrhea

difficult, fast, or noisy breathing

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast or irregular heartbeat

fever with or without chills

flushed, dry skin

fruit-like breath odor

general body swelling

general feeling of discomfort or illness

greatly decreased frequency of urination or amount of urine

hives or welts, skin rash

increased hunger

increased thirst

inverted nipple

joint pain, stiffness, or swelling

lower back or side pain

lump in the breast or under the arm

muscle cramps or pain

nausea and vomiting

numbness, tingling, pain, or weakness in the hands, feet, or lips

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

persistent non-healing sore

pink growth

pinpoint red or purple spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red, irritated eyes

reddish patch or irritated area

redness or swelling of the breast

redness, soreness, or itching skin

seizures

shiny bump

sore on the skin of the breast that does not heal

sores, ulcers, or white spots on the lips or in the mouth

stomach cramping, burning, or tenderness

swelling of the face, hands, fingers, feet, or lower legs

swollen, painful, or tender lymph glands in the neck, armpit, or groin

trembling

trouble breathing

unusual bleeding or bruising

unusual tiredness or weakness

white, yellow or waxy scar-like area

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Difficulty with sleeping

disorientation

drowsiness to profound coma

hallucination

lethargy

lightheadedness

mood or other mental changes

rash with flat lesions or small raised lesions on the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Absent, missed, or irregular menstrual periods

bleeding after menopause

burning feeling in the chest or stomach

discoloration of the skin

feeling of constant movement of self or surroundings

inability to have or keep an erection

increased sensitivity of the skin to sunlight

muscle spasm

restlessness

sensation of spinning

severe sunburn

stomach upset

stopping of menstrual bleeding

swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Aldactazide (spironolactone / hydrochlorothiazide)

thumbs-up

Pros

Combines two different kinds of diuretics into a single pill for convenience

Helps minimize potassium loss

Can take at any time of day

Can take with or without food

thumbs-down

Cons

Can't customize the dose of each individual ingredient since it's a combination medication

Can make you urinate more often

Can cause breast growth in males

Need regular blood tests to check your potassium levels and kidney function

pharmacist-tips

Pharmacist tips for Aldactazide (spironolactone / hydrochlorothiazide)

pharmacist

  • Mark your calendar with your appointments to follow up with your prescriber about how well Aldactazide (spironolactone / hydrochlorothiazide) is working for you. Also get any blood work done as scheduled. Checking your electrolyte levels and kidney function through blood work helps make sure the medication is safe for you. Your prescriber can adjust the dose of your medication, if needed.

    • Take Aldactazide (spironolactone / hydrochlorothiazide) with or without food at the same time every day. Taking it with food can help ease any upset stomach from the medication.

      • Ask your prescriber whether you should take your Aldactazide (spironolactone / hydrochlorothiazide) dose all at once each day or whether you should split the dose into smaller ones that are taken throughout the day. For example, if you need to take 2 tablets of the medication per day for your dose, you have the option to take the tablets at the same time once a day or take 1 tablet twice a day at different times.

        • You might feel dizzy when you start taking Aldactazide (spironolactone / hydrochlorothiazide) or when your prescriber raises the dose. Dizziness typically goes away as your body gets used to the medication and to the lowered blood pressure. But let your healthcare team know if the dizziness is making it hard for you to go about your day. Don't drive until you know how this medication affects you.

          • Take Aldactazide (spironolactone / hydrochlorothiazide) exactly as prescribed. Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Otherwise, it's possible for your blood pressure to rise quickly or for fluid to build up in your body again. Your prescriber will work with you to lower your dose slowly over time, if needed.

            • Ask your care team about what types of food you can or can't eat while you're taking Aldactazide (spironolactone / hydrochlorothiazide). Follow a balanced and nutritious diet that's low in salt to help manage your condition. But avoid adding salt substitutes containing potassium to your food and ask your care team how much potassium-rich foods you should have, since this medication can raise your potassium levels.

              • Avoid alcohol or limit how much alcohol you drink while you're taking Aldactazide (spironolactone / hydrochlorothiazide). Drinking alcohol regularly, particularly in high amounts, can make your blood pressure go up. Alcohol can also make some side effects, like sleepiness, dizziness, and frequent urination, worse.

                • Contact your prescriber right away if you become pregnant or are thinking of getting pregnant while you're taking Aldactazide (spironolactone / hydrochlorothiazide). There are other recommended blood pressure medications during pregnancy, so your prescriber might consider a different medication for you.

                  faqs

                  Frequently asked questions about Aldactazide (spironolactone / hydrochlorothiazide)

                  Why are spironolactone and hydrochlorothiazide given together?
                  Both spironolactone and hydrochlorothiazide are two different types of diuretics (water pills) that help get rid of extra fluid from the body. Your prescriber might consider both medications if you're already taking hydrochlorothiazide and it's either not giving you the best results for your condition or making you have potassium levels that are too low. In addition to helping to remove extra fluid from the body, spironolactone also helps to prevent potassium loss from hydrochlorothiazide. Aldactazide (spironolactone / hydrochlorothiazide) can be a convenient option in this situation because it contains the two medications in a single tablet.
                  Is Aldactazide (spironolactone / hydrochlorothiazide) a thiazide diuretic?
                  Yes. One of the active ingredients in Aldactazide is hydrochlorothiazide, which is a thiazide diuretic. It helps the body get rid of extra salt and water through the urine. The other ingredient in this combination medication is spironolactone, which is a potassium-sparing diuretic. Spironolactone works similarly and it also helps prevent potassium levels from dropping too low from the hydrochlorothiazide part.
                  How quickly does Aldactazide (spironolactone / hydrochlorothiazide) work?
                  In general, Aldactazide starts to work within a few hours. This medication contains a combination of two diuretics: spironolactone and hydrochlorothiazide. So more specifically, spironolactone starts to work within 2 to 4 hours, and hydrochlorothiazide starts to work within an hour. Note that it can take a couple days to see the full effects of the medication. It can also take some time for your prescriber to find a dose that works best for you, and they might need to adjust your dose accordingly. Follow up with your prescriber about how well the medication is working for you.
                  When's the best time to take Aldactazide (spironolactone / hydrochlorothiazide)?
                  You can take Aldactazide (spironolactone / hydrochlorothiazide) at any time of day. The most important thing is to take the medication consistently around the same time each day. However, because this medication can make you urinate more often than usual, you might consider taking Aldactazide (spironolactone / hydrochlorothiazide) in the morning or early afternoon. Talk with your care team if you have any questions about the best time to take Aldactazide (spironolactone / hydrochlorothiazide).
                  Does Aldactazide (spironolactone / hydrochlorothiazide) cause weight gain?
                  No, Aldactazide (spironolactone / hydrochlorothiazide) doesn't cause weight gain. You might actually notice some weight loss because it's a diuretic that makes you urinate out the extra fluid in your body. So more specifically, you might lose some water weight while you're taking Aldactazide (spironolactone / hydrochlorothiazide). Check your weight while you're taking this medication, especially if you have heart failure. Let your prescriber know if you notice any concerning weight changes.
                  Does Aldactazide (spironolactone / hydrochlorothiazide) cause hair loss?
                  Hair loss isn't a commonly reported side effect of Aldactazide (spironolactone / hydrochlorothiazide). Contact a healthcare professional if you notice concerning hair loss while you're taking Aldactazide (spironolactone / hydrochlorothiazide). They can help you figure out what might be the cause.
                  Does Aldactazide (spironolactone / hydrochlorothiazide) cause sun sensitivity?
                  Yes, sensitivity to sunlight is a potential side effect of the hydrochlorothiazide active ingredient in Aldactazide, but it's rare. When your skin gets more sensitive to the sun, it might be easier for you to get sunburns. You can lower the risk for sunburns by wearing sunscreen and wearing long-sleeved clothing when going outside. Also, it's best to avoid tanning. Talk to your prescriber about other ways to manage this possible side effect.
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                  What are the risks and warnings for Aldactazide (spironolactone / hydrochlorothiazide)?

                  Aldactazide (spironolactone / hydrochlorothiazide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  High potassium levels

                  • Risk factors: Kidney problems | Illness that could affect kidney function | Diabetes | Taking other medications that raise potassium | Using potassium-based salt substitutes | Potassium-rich diet

                    The spironolactone in Aldactazide can raise the amount of potassium in your body, which can sometimes be dangerous. Your risk is greater if you have diabetes or kidney problems or if you're taking other medications that also raise potassium levels. For this reason, make sure your prescriber knows your full medical history and the medications you're taking before you start treatment. Tell a healthcare professional right away if you have signs of high potassium levels, like nausea, muscle weakness, or a numbing or tingling feeling.

                    risk-warning

                    Changes in electrolyte, blood sugar, and cholesterol levels

                    In addition to potassium, Aldactazide (spironolactone / hydrochlorothiazide) can affect the level of other electrolytes in your body, including sodium and magnesium. You might need blood work done regularly while you're taking this medication to check your electrolyte levels. Tell your care team if you have a fast heartbeat, muscle pain or cramps, or nausea. Also let them know if you feel weak, have low energy, or notice that you're urinating less than usual. These can be signs of electrolyte changes in your body.

                    In addition, hydrochlorothiazide can raise your blood sugar levels. Tell your prescriber if you have diabetes or a history of having high blood sugar levels. Your prescriber might recommend that you check your blood sugar at home, or they might order a blood test to check your blood sugar levels once in awhile.

                    Hydrochlorothiazide can also raise your cholesterol levels. Make sure to go get your blood work done if your prescriber orders a blood test while you're taking Aldactazide (spironolactone / hydrochlorothiazide) to check your cholesterol levels.

                    risk-warning

                    Low blood pressure and dizziness

                    • Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking higher doses of diuretic medications

                      Sometimes, taking Aldactazide (spironolactone / hydrochlorothiazide) can cause your blood pressure to drop too much, especially when you stand up. This can make you feel dizzy, tired, or lightheaded. Having instances of low blood pressure is more common when you first start Aldactazide (spironolactone / hydrochlorothiazide) or when the dose is raised.

                      To prevent low blood pressure and dizziness, make sure to stay well hydrated. Ask your care team how much fluid you need each day. If you feel dizzy at any time while you're taking Aldactazide (spironolactone / hydrochlorothiazide), make sure to sit down slowly while holding onto something. Contact your prescriber if you feel dizzy, lightheaded, faint, tired, or confused while you're taking Aldactazide (spironolactone / hydrochlorothiazide). These can be signs that your blood pressure is too low.

                      risk-warning

                      Breast growth or breast pain

                      • Risk factors: Taking high doses of spironolactone | Taking Aldactazide (spironolactone / hydrochlorothiazide) for a long time

                        The spironolactone in Aldactazide can cause breast growth in males, or gynecomastia. The medication can also cause breast pain or tenderness in both males and females. It usually goes away when you stop taking Aldactazide (spironolactone / hydrochlorothiazide), but it rarely can be permanent. Talk to your prescriber if you notice unusual or concerning breast growth or breast pain. Your prescriber can discuss with you about lowering your dose or trying other options to treat your condition.

                        risk-warning

                        Vision problems

                        • Risk factors: Sulfa or penicillin allergies

                          It's rare, but some people might have vision changes or eye pain within hours or weeks after starting Aldactazide. This can happen because the hydrochlorothiazide component of the combination medication can suddenly elevate the pressure in the eye. Stop taking Aldactazide (spironolactone / hydrochlorothiazide) and call your prescriber right away if you notice any eye pain, blurry vision, or other changes in vision. In some cases, you might need additional treatment to help avoid permanent vision loss.

                          risk-warning

                          Lupus

                          Although rare, some people who took thiazide diuretics, like hydrochlorothiazide in this combination medication, developed lupus. In addition, some people who already had lupus experienced flares or worsened symptoms after they started taking hydrochlorothiazide. Let your prescriber know if you notice a rash across your cheeks and nose, feel very tired, or have joint pain. These can be symptoms of lupus.

                          risk-warning

                          Allergic reaction

                          • Risk factors: History of sulfa allergies

                            People with allergies to other sulfa-containing medications might experience similar reactions when they take Aldactazide (spironolactone / hydrochlorothiazide). Make sure your prescriber and pharmacist know about all of your allergies, especially if they were severe. Get medical attention right away if you notice rash, trouble breathing, or other signs of an allergic reaction.

                            dosage

                            Aldactazide (spironolactone / hydrochlorothiazide) dosage forms

                            The average cost for 90 tablets of 25mg/25mg of Aldactazide (spironolactone / hydrochlorothiazide) is $280.17 with a free GoodRx coupon. This is -2.44% off the average retail price of $273.50.
                            tablet
                            Tablet
                            DosageQuantityPrice as low asPrice per unit
                            25mg/25mg100 tablets$280.17$2.80
                            50mg/50mg90 tablets$457.13$5.08

                            Typical dosing for Aldactazide (spironolactone / hydrochlorothiazide)

                            • Swelling due to liver cirrhosis, nephrotic syndrome, or heart failure: The typical dose is 100 mg/100 mg (spironolactone/hydrochlorothiazide) by mouth per day. It can be given as a single dose once a day or split up into smaller doses throughout the day. Your prescriber will adjust your dose depending on how well the medication works for you.

                            • High blood pressure: The typical dose is 50 mg/50 mg to 100 mg/100 mg (spironolactone/hydrochlorothiazide) by mouth per day. This can be given as a single dose once a day or split up into smaller doses throughout the day. Your prescriber will adjust your dose depending on how well the medication helps with your blood pressure.

                            interactions

                            Interactions between Aldactazide (spironolactone / hydrochlorothiazide) and other drugs

                            Aldactazide (spironolactone / hydrochlorothiazide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Aldactazide (spironolactone / hydrochlorothiazide). Please note that only the generic name of each medication is listed below.

                            Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                            drug-cost

                            How much does Aldactazide (spironolactone / hydrochlorothiazide) cost?

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                            contraindications-icon

                            Aldactazide (spironolactone / hydrochlorothiazide) contraindications

                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Aldactazide (spironolactone / hydrochlorothiazide) will not be safe for you to take.
                            alternatives

                            What are alternatives to Aldactazide (spironolactone / hydrochlorothiazide)?

                            There are a number of medications that your doctor can prescribe in place of Aldactazide (spironolactone / hydrochlorothiazide). Compare a few possible alternatives below.
                            Aldactazide (spironolactone / hydrochlorothiazide)
                            Used for:
                            $97.07 Lowest GoodRx priceView Prices
                            Maxzide (triamterene / hydrochlorothiazide)
                            Used for:

                            • High blood pressure

                            • Swelling

                            $4.00 Lowest GoodRx priceView Prices
                            Amiloride/hydrochlorothiazide
                            Used for:
                            $32.95 Lowest GoodRx priceView Prices
                            images

                            Aldactazide (spironolactone / hydrochlorothiazide) images

                            Beige Round M 41 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet
                            This medicine is Beige, Round, Scored Tablet Imprinted With "M 41".Beige Round M 41 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet
                            Beige Round Mp 40 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet
                            This medicine is Beige, Round Tablet Imprinted With "Mp 40".Beige Round Mp 40 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet
                            Tan Round G And 5014 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet
                            This medicine is Tan, Round Tablet Imprinted With "G" And "5014".Tan Round G And 5014 - Spironolactone / Hydrochlorothiazide 25mg-25mg Tablet

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                            References

                            Best studies we found

                            Carone, L., et al. (2017). Spironolactone. Journal of Pain and Symptom Management.

                            MedlinePlus. (2023). Potassium test.

                            Montford, J. R., et al. (2017). How dangerous is hyperkalemia? Journal of the American Society of Nephrology.

                            View All References (4)

                            National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Definition & facts of adrenal insufficiency & Addison's disease.

                            National Institute of Diabetes and Digestive and Kidney Diseases. (2020). Nephrotic syndrome in adults.

                            Pfizer Laboratories Div Pfizer Inc. (2024). Aldactazide- spironolactone and hydrochlorothiazide tablet, film coated [package insert]. DailyMed.

                            Tholey, D. (2023). Liver failure. Merck Manual Consumer Version.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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