Thiazide and potassium-sparing diuretic combinations are used to treat high blood pressure, heart failure, and edema (swelling). TThese medications work by combining two types of diuretics: thiazide diuretics, which help remove excess fluid and sodium from your body, and potassium-sparing diuretics, which help retain potassium to prevent low potassium levels. These combinations are available in oral form. Examples include triamterene/hydrochlorothiazide (Maxzide) and amiloride/hydrochlorothiazide. You can take these medications as prescribed to help manage your condition effectively.