The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
People with ulcerative colitis:
- COVID-19 symptoms (10%)
- Anemia (5%)
- Joint pain (4%)
- Reaction at the injection site (e.g., bruising, swelling, pain, redness; 3%)
- Elevated liver enzyme levels (3%)
- Belly pain (3%)
People with Crohn's disease:
- COVID-19 symptoms (10%)
- Headache (8%)
- Upper respiratory infections (7%)
- Reaction at the injection site (e.g., bruising, swelling, pain, redness; 5%)
- Diarrhea (5%)
- Higher creatine phosphokinase levels (4%)
- Joint pain (4%)
- Elevated liver enzyme levels (4%)
Less Common Side Effects
People with Crohn's disease:
- High blood pressure
- Urinary tract infection (UTI)
- Dizziness
- Low white blood cell count
Zymfentra serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infection: fever, difficulty breathing, cough, weakness, cough, sweating, chills, stomach pain, diarrhea, burning feeling when you urinate, urinating more frequently
- Symptoms of possible cancer: fatigue, loss of appetite, unusual skin changes, swollen lymph nodes, cough that doesn't go away, unexplained weight gain or weight loss, unusual bleeding
- Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion
- Heart failure: shortness of breath; swelling in the legs, ankles, or feet; irregular heartbeat; can't exercise; tiredness; weakness; sudden weight gain
- Low blood cell counts: fever, pale skin, fast heart rate, lightheadedness, easy bleeding or bruising, blood in urine or stool
- Problems related to the nervous system: seizure, changes in vision, weakness, numbness, tingling, balance problems
- Lupus-like symptoms: chest discomfort or pain, short of breath, joint or muscle pain, rash on cheeks or arms
- Serious allergic reaction: hives, itching, swelling of face or tongue, difficulty breathing, low blood pressure
Source: DailyMed
The following Zymfentra side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Lupus-like syndrome—joint pain, swelling, or stiffness, butterfly-shaped rash on the face, rashes that get worse in the sun, fever, unusual weakness or fatigue
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Cough
- Diarrhea
- Headache
- Pain, redness, or irritation at injection site
- Runny or stuffy nose
- Sore throat
- Stomach pain
