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Zeposia

Zeposia Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on September 11, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

Note: Side effects were reported by adults with MS. Side effects might differ for adults with UC.

Zeposia serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Infection: fever, chills, sweating, weakness, sore throat, trouble breathing, cough, diarrhea, stomach pain, painful urination
  • Serious brain infection (PML): weakness on one side of the body, clumsiness, confusion, changes in personality, changes in vision, changes in thinking or memory
  • Dangerously slow heart rate: tiredness, dizziness, lightheadedness, trouble breathing, chest pain, fainting
  • Dangerously high blood pressure: severe headaches, nosebleeds, trouble breathing, vision changes, irregular heartbeat, chest pain
  • Liver problems: nausea, vomiting, stomach pain, low appetite, yellowing of your skin or the whites of your eyes, dark urine
  • Vision problems: blurry vision, wavy vision, dull color vision
  • Posterior reversible encephalopathy syndrome (PRES): sudden and severe headache, changes in vision, changes in behavior, problems thinking or remembering
When do Zeposia possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Slower heart rate after taking
Risk of upper respiratory infection
Risk of other infection
Risk of higher liver enzymes
Higher blood pressure
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Zeposia side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Change in vision
  • Dizziness, loss of balance or coordination, confusion or trouble speaking
  • Fever, neck pain or stiffness, sensitivity to light, headache, nausea, vomiting, confusion, which may be signs of meningitis
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Shortness of breath
  • Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
  • Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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