The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Upper respiratory infection (26%)
- High liver enzyme levels (10%)
Less Common Side Effects
- Stomach pain
- Back pain
- Sudden low blood pressure when standing
- High blood pressure
- Urinary tract infection (UTI)
Note: Side effects were reported by adults with MS. Side effects might differ for adults with UC.
Zeposia serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infection: fever, chills, sweating, weakness, sore throat, trouble breathing, cough, diarrhea, stomach pain, painful urination
- Serious brain infection (PML): weakness on one side of the body, clumsiness, confusion, changes in personality, changes in vision, changes in thinking or memory
- Dangerously slow heart rate: tiredness, dizziness, lightheadedness, trouble breathing, chest pain, fainting
- Dangerously high blood pressure: severe headaches, nosebleeds, trouble breathing, vision changes, irregular heartbeat, chest pain
- Liver problems: nausea, vomiting, stomach pain, low appetite, yellowing of your skin or the whites of your eyes, dark urine
- Vision problems: blurry vision, wavy vision, dull color vision
- Posterior reversible encephalopathy syndrome (PRES): sudden and severe headache, changes in vision, changes in behavior, problems thinking or remembering
Source: DailyMed
The following Zeposia side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision
- Dizziness, loss of balance or coordination, confusion or trouble speaking
- Fever, neck pain or stiffness, sensitivity to light, headache, nausea, vomiting, confusion, which may be signs of meningitis
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Shortness of breath
- Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
- Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):


