The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea (65%)
- Low platelet count (60%)
- Low red blood cells (56%)
- Tiredness (55%)
- Constipation (39%)
- Muscle, bone, or joint pain (36%)
- Stomach pain (35%)
- Vomiting (33%)
- Poor appetite (24%)
Less Common Side Effects
- Difficulty sleeping
- Headache
- Difficulty breathing
- Rash
- Diarrhea
- High blood pressure
- Cough
- Dizziness
- Kidney problems
- Urinary tract infection
- Low magnesium levels
Zejula serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Bone marrow problems: infections, fever, trouble breathing, weight loss, bleeding or bruising more easily, blood in the urine or stool, weakness
- Extremely high blood pressure: headache, dizziness, nosebleeds
- Posterior reversible encephalopathy syndrome (PRES): severe headaches, seizures, confusion, changes in vision
Source: DailyMed
The following Zejula side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Fatigue
- Loss of appetite
- Muscle pain
- Nausea
- Trouble sleeping

