aspirin / omeprazole DR

Yosprala (aspirin / omeprazole) can irritate your stomach or intestines, which can feel like stomach pain or heartburn. It can also lead to serious stomach problems, including swelling, bleeding, and ulcers in the stomach or intestines. Your bleeding risk is higher if you drink alcohol, especially if you have three or more alcoholic drinks every day or drink regularly or heavily. The risk of bleeding is also higher if you're taking blood thinners like warfarin (Coumadin) or other NSAIDs (e.g., ibuprofen (Advil, Motrin), naproxen (Aleve)) with Yosprala (aspirin / omeprazole), since they can also cause bleeding. If you have stomach pain that doesn't get better, vomit blood or bits that look like coffee grounds, or have bloody or black, tarry stools, let your provider know right away. These might be signs of stomach bleeding or a stomach ulcer.

Yosprala (aspirin / omeprazole) can cause kidney damage at any time while you're taking the medication. The risk is especially high if you have a history of kidney problems or if you're taking Yosprala (aspirin / omeprazole) for a long period of time. Stop taking Yosprala (aspirin / omeprazole), and let your provider know if you're not urinating as often as usual or have fever, muscle weakness, nausea, or loss of appetite. These can be signs of kidney damage.

Yosprala (aspirin / omeprazole) might raise your risk of getting bone fractures (at the hip, wrist, or spine). Your risk is higher if you're taking the medication for more than 1 year, taking a higher dose of Yosprala (aspirin / omeprazole) than prescribed, or taking PPIs multiple times a day. If you have or are at risk of osteoporosis (bone weakening), discuss with your provider about ways to keep your bones healthy and if you need to take vitamin D and calcium supplements while taking this medication.

PPIs like the omeprazole in Yosprala (aspirin / omeprazole) can cause new or worsening lupus. Lupus is an autoimmune disease that can cause frequent fevers, tiredness, rash, or joint pain. Lupus can develop anytime while taking PPIs daily. If you notice any symptoms of lupus, stop Yosprala (aspirin / omeprazole) and contact your provider. Symptoms of lupus should improve within 4 to 12 weeks after stopping the medication.

In some rare cases, Yosprala (aspirin / omeprazole) can cause low levels of blood vitamin B12 or magnesium due to the omeprazole in it. This can happen with as little as 3 months of use, but more commonly occurs after you've been using Yosprala (aspirin / omeprazole) for a year or more. Your risk for low magnesium is higher if you're taking other medications that can cause low magnesium levels, like digoxin (Lanoxin) or furosemide (Lasix). Signs of low magnesium include irregular heart rate, muscle cramps, and tremors. Signs of low vitamin B12 include weakness, tiredness, "pins and needles" feeling in your hands and feet, dizziness, headaches, and pale skin. If you notice any of these symptoms, let your provider know. Your healthcare provider can do a blood test to see if you need to take a vitamin B12 or magnesium supplement while taking Yosprala (aspirin / omeprazole).

If you're pregnant and at 20 weeks of pregnancy or later, don't take Yosprala (aspirin / omeprazole). Taking aspirin doses that are 325 mg or higher at 20 weeks of pregnancy or later can cause developmental problems in your unborn baby's kidneys. It can also lower the level of fluid in your belly (oligohydramnios), which can affect your unborn baby's lung development. In addition, taking aspirin at 30 weeks of pregnancy or later can cause developmental problems in your unborn baby's heart. Discuss the risks and benefits of taking Yosprala (aspirin / omeprazole) during pregnancy with your provider.