The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low blood sugar (up to 37%)
- Common cold or flu (up to 10%)
- Headache (9%)
- Nausea (8%)
- Diarrhea (8%)
- Rise in a pancreas enzyme (lipase) (7%)
Less Common Side Effects
- Vomiting
- Constipation
- Upset stomach
- Stomach pain
- Heartburn
- Low appetite
- Low blood sugar
- Weight gain
- Swelling
- Injection-site reactions (e.g., redness, pain, bleeding, itching)
Xultophy serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Thyroid cancer: mass in the neck, trouble breathing or swallowing, hoarseness
- Inflammation of the pancreas (pancreatitis): severe stomach pain that spreads to your back, nausea, vomiting
- Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, can't think clearly
- Kidney damage: tiredness, dry and itchy skin, urinating more often, bloody or foamy urine, swelling in your feet or ankles, muscle cramping
- Dangerously low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
- Gallbladder problems: severe upper stomach and back pain, yellowing of your skin or eyes (jaundice), fever, nausea, vomiting
- Heart failure: shortness of breath, tiredness, swelling in your legs, ankles, or feet, sudden weight gain
- Severe allergic reaction: rash; hives; swelling of face, tongue, and throat; trouble breathing
Source: DailyMed
The following Xultophy side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Gallbladder problems—severe stomach pain, nausea, vomiting, fever
- Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
- Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat
- Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Thoughts of suicide or self-harm, worsening mood, feelings of depression
- Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Headache
- Loss of appetite
- Nausea
- Runny or stuffy nose
- Sore throat
- Upset stomach
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