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Xiaflex Coupon - Xiaflex 0.9mg vial

Xiaflex

collagenase clostridium histolyticum
Used for Connective Tissue Disorders
Used for Connective Tissue Disorders

Xiaflex is a collagen-specific enzyme that's used as a non-surgical treatment for adults with conditions called Peyronie's disease and Dupuytren’s contracture. It works by breaking down thickened tissue in certain parts of the body. This medication is injected into specific areas of thickened tissue with the help of a trained healthcare provider at a clinic. Side effects can include swelling and pain at the injected area. There's also a risk for serious ligament or tendon damage.

Last reviewed on December 20, 2023
basics-icon

What is Xiaflex (collagenase)?

What is Xiaflex (collagenase) used for?

  • Dupuytren’s contracture in certain adults

  • Peyronie’s disease in certain men

How Xiaflex (collagenase) works

Xiaflex (collagenase) is an enzyme (protein) that breaks down collagen.

  • For Dupuytren’s contracture, it breaks up hard tissue caused by stored up collagen in the hand. This helps straighten bent fingers.

  • For Peyronie's disease, it breaks up (or plaque) under the skin of the penis that causes it to curve.

Drug Facts

Common BrandsXiaflex
Drug ClassCollagen-specific enzyme
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Xiaflex (collagenase)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Peyronie's disease:
  • Bruising in the penis (up to 66%)
  • Swelling of the penis (55%)
  • Pain in the penis (45%)
Dupuytren’s contracture:
  • Swelling (usually of the injected hand; 73%)
  • Bruising (70%)
  • Bleeding at the injection site (38%)
  • Injection site reaction (e.g., redness, irritation, warmth; 35%)
  • Pain in the injected hand (35%)
  • Tenderness (24%)
  • Swelling at the injection site (24%)

Other Side Effects

Peyronie's disease:
  • Blood blister
  • Penis blister
  • Itchy genitals
  • Pain during injection procedure
  • Painful erection
  • Pain during sex
  • Erectile dysfunction
  • Skin color changes
Dupuytren’s contracture:
  • Itchiness
  • Skin cut
  • Skin redness
  • Swollen or painful lymph nodes
  • Armpit pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Complications from treatment for Peyronie's disease: severe pain, swelling, or bruising on penis; blood in urine; sharp back pain
  • Complications from treatment for Dupuytren's contracture: changes in sensation of touch in your finger(s); trouble bending your finger(s); deep skin cuts
  • Serious allergic reaction: hives; chest pain; trouble breathing; swelling of your lips, tongue, or face; dizziness; fainting; anaphylaxis

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—Dupuytren's contracture

Bruising or bleeding at the injection site

swelling of the hands

tearing of the skin

More common—Peyronie's disease

Itching, pain, redness, swelling, or bruise of the penis

popping sound or sensation in an erect penis

Less common—Peyronie's disease

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

painful sexual intercourse

Incidence not known—Dupuytren's contracture

Bone pain

lower back or side pain

painful, swollen joints

Incidence not known—Peyronie's disease

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or tightness

difficult or labored breathing

lower back pain, possibly radiating to the legs, feet, arms, or chest

muscle spasms

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—Dupuytren's contracture

Blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, lumps, numbness, rash, scarring, stinging, tingling, or ulceration at the injection site

bruise

flushing, redness of the skin or unusually warm skin at the injection site

itching, pain, swelling, or tenderness at the injection site

swollen, painful, or tender lymph glands in the neck or armpit

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Xiaflex (collagenase)

thumbs-up

Pros

Directly injected into the area that's causing the problem

Can get multiple injections over time depending on your response to treatment

thumbs-down

Cons

Must be injected by a trained healthcare provider

Commonly causes discomfort at the injection site

Unknown if safe or works well for children under 18 years old

pharmacist-tips

Pharmacist tips for Xiaflex (collagenase)

pharmacist

For Peyronie's disease:

  • After your Xiaflex (collagenase) injection, it's normal to see some bruising and swelling on your penis. But call your provider right away if you have severe pain, swelling, or bruising on your penis; blood in your urine; or trouble urinating.

    • Your provider will teach you exercises to do at home to help stretch and straighten your penis. Do these exercises every day for 6 weeks after each treatment.

      • To help with healing, don't have sex between the first and second injections of a Xiaflex (collagenase) treatment cycle and for at least 4 weeks after the second injection of a treatment cycle. Ask your provider when you can have sex again after each treatment cycle.

        • Avoid using a vacuum erection device during treatment with Xiaflex (collagenase).

          • Make sure to avoid situations that could cause you to strain your stomach muscles, like straining to have a bowel movement, while you're getting treated with Xiaflex (collagenase).

            For Dupuytren’s contracture:

            • Don't flex or extend your fingers after your Xiaflex (collagenase) injection(s) until your provider gives you further instructions. This lessens the risk of having medication leak out of the cord(s). Also, don't mess with the injected cord after your treatment.

              • Keep your injected hand elevated (raised) until you go to bed on the day of your injection(s).

                • Be sure to go to your follow-up appointment about 1 to 3 days after your Xiaflex (collagenase) injection(s). Your provider will gently stretch the affected finger to help straighten it.

                  • Follow your provider's instructions to do finger exercises every day for a few months to help stretch your fingers. Your provider will also give you a finger splint to protect your finger and keep it straight while you sleep; use the splint for a few months after treatment.

                    faqs

                    Frequently asked questions about Xiaflex (collagenase)

                    How long does it take to recover from Xiaflex (collagenase) injections for Peyronie's disease?
                    It might take a few weeks to completely recover from Xiaflex (collagenase) injections for Peyronie's disease. To help with healing, avoid doing activities that can cause injury to your penis. Don't have sex between the first and second injections of a treatment cycle. Also wait at least 4 weeks after the second injection of a treatment cycle to have sex. Call your provider right away if you have any severe pain, swelling, or bruising of the penis; trouble urinating; or blood in the urine after your injection. These can be signs of complications from treatment.
                    What should I expect after Xiaflex (collagenase) injections for Dupuytren's contracture?
                    Your provider will schedule a follow-up appointment with you about 1 to 3 days after your Xiaflex (collagenase) injection(s). At this appointment, your provider will stretch your finger to help straighten it. You'll be provided with a finger splint to use to protect your finger and keep it straight when you sleep; use the splint for a few months after treatment. Your provider might also instruct you to do finger exercises every day for a few months. Schedule another appointment in about 4 weeks so your provider can check how well the Xiaflex (collagenase) injection(s) worked.
                    How effective is Xiaflex (collagenase) for Peyronie's disease?
                    In clinical studies, men with Peyronie's disease who took Xiaflex (collagenase) saw on average of almost 35% improvement in the bend of the penis after four treatment cycles within a year. In comparison, those who took placebo saw on average of almost 20% improvement. People who took Xiaflex (collagenase) also had improvements related to concerns about erection pain and appearance and about how much Peyronie's disease affects sex for them. Speak with your provider after your Xiaflex (collagenase) injection(s) to discuss how well the medication is working for you.
                    How effective is Xiaflex (collagenase) for Dupuytren's contracture?
                    In clinical studies, treatment with Xiaflex (collagenase) helped straighten the affected finger of over 6 out of 10 adults with Dupuytren’s contracture. In addition, the range of motion in the affected joints of the finger significantly improved after injections with the medication. Follow up with your provider after your Xiaflex (collagenase) injection(s) to discuss how well the medication is working for you.
                    How is Xiaflex (collagenase) administered?
                    Xiaflex (collagenase) is given as an injection directly into the scar tissue by a trained healthcare provider. For treating Dupuytren’s contracture, the medication is injected directly into the cord of tissue in your hand. And for treating Peyronie's disease, the medication is injected directly into the bump in the penis (Peyronie's plaque) that's causing the penis to bend.
                    Is Xiaflex (collagenase) treatment painful?
                    It could be. In clinical studies, some men with Peyronie’s disease who were treated with Xiaflex (collagenase) had pain at the injection site on the penis. If you'd like, you can ask your provider for a numbing medication to lessen any pain before the injection. In addition, some adults with Dupuytren’s contracture treated with Xiaflex (collagenase) felt pain in the injected hand. Your provider won't be able to use a numbing medication beforehand because it could affect the placement of the Xiaflex (collagenase) injection in your hand. But you can ask for a numbing medication for your finger-stretching procedure at your follow-up visits.
                    Is there a generic for Xiaflex (collagenase)?
                    There are currently no generic versions of Xiaflex (collagenase). This medication is available as brand name only.
                    What's the difference between Peyronie's disease and Dupuytren’s contracture?
                    Peyronie's disease and Dupuytren’s contracture are both connective tissue conditions that are worsened by a buildup of collagen, but they affect different areas. Peyronie's disease affects the penis and can cause bent erections, painful erections, and an obvious bump in the penis. Dupuytren’s contracture affects the hand and can cause finger(s) to curl towards the palm of your hand. Xiaflex (collagenase) is helpful for both of these conditions since it helps reduce stored collagen deposits.
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                    What are the risks and warnings for Xiaflex (collagenase)?

                    Xiaflex (collagenase) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Serious injury to the penis (for Peyronie's disease only)

                    Xiaflex (collagenase) should only be injected by a trained healthcare provider. When treating Peyronie's disease, providers are trained to avoid injecting into the urethra (a structure needed for urination), nerves, blood vessels, erectile tissue inside the penis, or other collagen-containing structures of the penis. Injection into these areas can cause severe injury, such as a penile fracture. In some serious situations, surgery might be necessary.

                    Because of the serious risk for penile injury, Xiaflex (collagenase) is only available through a restricted Risk and Evaluation Mitigation Strategy (REMS) program called the Xiaflex REMS program. This program helps make sure that only trained providers inject this medication, people are made aware of its risks, and only certified healthcare settings provide it.

                    risk-warning

                    Tendon rupture or serious injury to the injected finger or hand (for Dupuytren's contracture only)

                    Xiaflex (collagenase) should only be injected by a trained healthcare provider. When treating Dupuytren’s contracture, providers are trained to avoid injecting into tendons, nerves, blood vessels, or other collagen-containing structures of the hand. Injection into these areas can cause permanent or severe injury, such as tendon rupture, ligament damage, or deep skin cuts. In some serious situations, surgery might be necessary.

                    risk-warning

                    Allergic reactions

                    • Risk factors: More injections of Xiaflex (collagenase) than recommended

                      Some people who got more injections of Xiaflex (collagenase) than recommended had mild allergic reactions, such as itching. In addition, it's possible to have severe allergic reactions to Xiaflex (collagenase). This can include anaphylaxis (e.g., closing of the throat). Tell your provider or get medical help right away if you feel itchy, dizzy, or faint or if you have hives, chest pain, trouble breathing, or swelling of your lips, tongue, or face.

                      risk-warning

                      Bleeding risk

                      • Risk factors: Medical history of blood clotting problems | Taking blood thinners

                        In clinical studies of people with Dupuytren’s contracture, Xiaflex (collagenase) commonly caused bruising or bleeding at the injection site on the hand. In clinical studies of people with Peyronie's disease, Xiaflex (collagenase) also often caused bruising at the injection site on the penis.

                        Bleeding can be especially dangerous if you have a history of a clotting problem or if you're taking blood thinners because these factors can raise your risk of bleeding even more. Make sure to tell your provider about your full medical history and all the medications you're taking before you start Xiaflex (collagenase) treatments.

                        risk-warning

                        Sudden back pain after injections

                        • Risk factors: Treating Peyronie's disease

                          Some people with Peyronie's disease reported having sudden back pain immediately or within minutes after Xiaflex (collagenase) injections. The feeling can either be mild or quite severe and can spread to the legs, arms, and chest. Usually, this pain only happens after you've gotten a few injections already; it typically doesn't happen after the first injection. This pain usually goes away after about half an hour, and you usually don't need any additional medications to help treat the pain. Let your provider know if you have any back pain after your injection(s).

                          risk-warning

                          Lightheadedness and fainting

                          Some people who were treated with Xiaflex (collagenase) felt lightheaded or have fainted. For people with Peyronie's disease, most cases were related to having pain in the penis or pain while urinating after injections. For people with Dupuytren's contracture, most cases were related to the treatment procedure or pain from the injections; these symptoms typically happened right after or within 1 to 2 days after the procedure. Lie down if you feel lightheaded or faint until these symptoms go away so you don't hurt yourself.

                          dosage

                          Xiaflex (collagenase) dosage forms

                          Typical dosing for Xiaflex (collagenase)

                          This medication is given as an injection directly into the scar tissue by a trained healthcare provider. Your provider will determine how many treatments of Xiaflex (collagenase) you need based on how you respond to the medication.

                          • Dupuytren’s contracture: Your provider will inject 0.58 mg directly into the cord of tissue in your hand. You can get an injection in up to two joints in your hand during a treatment visit. You can have up to 3 treatment visits that are each one month apart.

                          • Peyronie's disease: Your provider will inject 0.58 mg directly into a bump in your penis (Peyronie's plaque). This is followed by a second injection 1 to 3 days later. Your provider will inject Xiaflex (collagenase) into the plaque that's causing the penis to bend. You might need up to 4 treatment cycles that are each six weeks apart.

                          interactions

                          Interactions between Xiaflex (collagenase) and other drugs

                          Xiaflex (collagenase) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Xiaflex (collagenase). Please note that only the generic name of each medication is listed below.

                          Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

                          contraindications-icon

                          Xiaflex (collagenase) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xiaflex (collagenase) will not be safe for you to take.
                          • Peyronie’s plaques that involve the penile urethra (tube that lets urine out of the body)

                          • Allergy to other collagenase products

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                          Xiaflex (collagenase) images

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                          This medicine is White Vial.white - Xiaflex 0.9mg Powder for Injection

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                          References

                          Best studies we found

                          Alipour, H., et al. (2016). Therapeutic applications of collagenase (metalloproteases): A review. Asian Pacific Journal of Tropical Biomedicine.

                          American Society for Surgery of the Hand. (2021). Dupytren’s contracture.

                          Endo Pharmaceuticals Inc. (2022). Xiaflex- collagenase clostridium histolyticum kit [package insert]. DailyMed.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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