The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Peyronie's disease:
- Bruising in the penis (up to 66%)
- Swelling of the penis (55%)
- Pain in the penis (45%)
Dupuytren’s contracture:
- Swelling (usually of the injected hand; 73%)
- Bruising (70%)
- Bleeding at the injection site (38%)
- Injection site reaction (e.g., redness, irritation, warmth; 35%)
- Pain in the injected hand (35%)
- Tenderness (24%)
- Swelling at the injection site (24%)
Less Common Side Effects
Peyronie's disease:
- Blood blister
- Penis blister
- Itchy genitals
- Pain during injection procedure
- Painful erection
- Pain during sex
- Erectile dysfunction
- Skin color changes
Dupuytren’s contracture:
- Itchiness
- Skin cut
- Skin redness
- Swollen or painful lymph nodes
- Armpit pain
Xiaflex serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Complications from treatment for Peyronie's disease: severe pain, swelling, or bruising on penis; blood in urine; sharp back pain
- Complications from treatment for Dupuytren's contracture: changes in sensation of touch in your finger(s); trouble bending your finger(s); deep skin cuts
- Serious allergic reaction: hives; chest pain; trouble breathing; swelling of your lips, tongue, or face; dizziness; fainting; anaphylaxis
Source: DailyMed
The following Xiaflex side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common—Dupuytren's contracture
Bruising or bleeding at the injection site
swelling of the hands
tearing of the skin
More common—Peyronie's disease
Itching, pain, redness, swelling, or bruise of the penis
popping sound or sensation in an erect penis
Less common—Peyronie's disease
Decreased interest in sexual intercourse
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
painful sexual intercourse
Incidence not known—Peyronie's disease
Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or tightness
difficult or labored breathing
lower back pain, possibly radiating to the legs, feet, arms, or chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common—Dupuytren's contracture
Blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, lumps, numbness, rash, scarring, stinging, tingling, or ulceration at the injection site
bruise
flushing, redness of the skin or unusually warm skin at the injection site
itching, pain, swelling, or tenderness at the injection site
swollen, painful, or tender lymph glands in the neck or armpit
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Other Xiaflex articles
