The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Elevated liver enzymes (53%)
- Diarrhea (52%)
- Elevated blood sugar (41%)
- High blood pressure (40%)
- Changes in hair color (e.g., lighter hair color; 38%)
- Low white blood cell levels (up to 37%)
- Elevated bilirubin levels (36%)
- Low platelet levels (32%)
- Nausea (26%)
- Loss of appetite or not feeling hungry (22%)
- Vomiting (21%)
- Fatigue (19%)
- Low blood sugar (17%)
Less Common Side Effects
- Weakness
- Headache
- Taste changes
- Indigestion
- Belly pain
- Chest pain
- Hoarseness
- Hair loss
- Rash
- Hand-foot syndrome
- Changes in skin color (e.g., lighter skin color)
- Weight loss
- Protein in the urine (cloudy urine)
Note: Side effects listed here were reported by people with renal cell carcinoma during clinical studies. Side effects might differ for people with soft tissue sarcoma.
Votrient serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: body aches, chills, fever, headache, new cough, sore throat, tiredness
- Serious heart problems: chest pounding, chest pain, irregular heartbeat, shortness of breath, lightheadedness, swelling in the legs
- Gut problems: fever; chills; intense stomach pain or cramps; bloating; skin irritation, swelling, or redness around the anus; discharge from the anus; blood in stool
- Serious liver problems: right-sided stomach pain, tiredness, loss of appetite, yellowing of the skin or eyes
- Serious bleeding: unusual bleeding, bleeding that’s hard to stop, easy bruising, blood in urine or stool
- Blood clot in the lungs or serious lung problems: cough, chest pain, trouble breathing, shortness of breath, racing heart
- Blood clot near the heart: chest pain, stomach discomfort, sweating, nausea, dizziness
- Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
- Dangerously high blood pressure: anxiety, blurry vision, confusion, chest pain, nausea, vomiting, headache
- Tumor lysis syndrome: fever, chills, nausea or vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, muscle or joint pain, unusual tiredness
Source: DailyMed
The following Votrient side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Black, tarry stools
bleeding gums
blood in the urine or stools
blurred vision
chills
clay colored stools
cloudy urine
coughing up blood
dark urine
decreased appetite
depressed mood
difficulty with breathing or swallowing
dizziness
dry skin and hair
feeling cold
headache
hoarseness or husky voice
increased menstrual flow or vaginal bleeding
itching, skin rash
loss of appetite
lower back or side pain
muscle cramps and stiffness
nervousness
nosebleeds
painful or difficult urination
pale skin
paralysis
pinpoint red spots on the skin
pounding in the ears
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
redness, swelling, or pain of the skin
scaling of the skin on the hands and feet
slow or fast heartbeat
sores, ulcers, or white spots on the lips or in the mouth
stomach pain or tenderness
swelling of the feet or lower legs
swollen glands
tingling of the hands and feet
ulceration of the skin
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Less common
Bleeding from the rectum or bloody stools
bloody nose
chest discomfort
confusion
fainting
irregular or slow heart rate
numbness or tingling in the face, arms, or legs
pain or discomfort in the shoulders, arms, jaw, back, or neck
sweating
swelling or puffiness of the face
trouble speaking, thinking, or walking
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Change in hair color
change in taste
decreased weight
lack or loss of strength
loss of taste
thinning of the hair
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
