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Vivjoa Coupon - Vivjoa 18 capsules of 150mg carton

Vivjoa

oteseconazole
Used for Yeast Infection
Used for Yeast Infection

Vivjoa (oteseconazole) is an fda-approved antifungal medication to reduce yeast infections in people with vaginal yeast infections that keep coming back, also known as recurrent vulvovaginal candidiasis (RVVC). The medication shouldn't be taken by those who can get pregnant because it might cause harm to unborn babies, especially since it stays in your body for around 2 years after the last dose. Common side effects include headache and nausea. It's only available as a brand-name medication.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on July 21, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
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What is Vivjoa (oteseconazole)?

What is Vivjoa (oteseconazole) used for?

How Vivjoa (oteseconazole) works

Vivjoa (oteseconazole) is an azole antifungal medication that kills the fungus that causes yeast infections. It does so by blocking the fungus from making an important substance needed for its outer protective layer. It also kills the fungus by causing a toxic substance to build up inside of it.

Drug Facts

Common BrandsVivjoa
Drug ClassAzole antifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Vivjoa (oteseconazole)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (7%)
  • Nausea (4%)

Other Side Effects

  • Stomach upset
  • Hot flush
  • Painful urination
  • Vaginal bleeding
  • Vaginal irritation

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Vivjoa (oteseconazole)

thumbs-up

Pros

First FDA-approved medication for RVVC

Only taken once per day or once per week

Works well up to almost a year after starting treatment

Doesn't interact with as many medications compared to similar medications

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Cons

Available as a brand-name medication only

Can't be used in people who are able to become pregnant

Not recommended in people with severe kidney or liver problems

Must be taken with food in order to work fully

pharmacist-tips

Pharmacist tips for Vivjoa (oteseconazole)

pharmacist

  • The dosing schedule for Vivjoa (oteseconazole) can be confusing. Keep track of the days on your calendar when taking the medication, since you'll start taking it daily and then move to once a week dosing.

    • Take Vivjoa (oteseconazole) with food to help it get absorbed better, and swallow the Vivjoa (oteseconazole) capsules whole. Don't crush, chew, open, or dissolve the capsules, since this could damage the medication or prevent you from getting your full dose.

      • Vivjoa (oteseconazole) can raise the levels of some medications if taken together, like rosuvastatin (Crestor). This can lead to more side effects from the other medication. Make sure to tell your prescriber all of the medications you're taking before starting Vivjoa (oteseconazole).

        • Don't stop taking Vivjoa (oteseconazole) suddenly without speaking with your prescriber first, even if you begin to feel better. Stopping too early can cause yeast infections to come back stronger.

          • To help prevent yeast infections, a few things you can do include wearing cotton underwear, changing out of wet swimsuits and workout clothes as soon as possible, and avoiding certain scented products.

            faqs

            Frequently asked questions about Vivjoa (oteseconazole)

            Is Vivjoa (oteseconazole) available in the United States?
            Yes. Vivjoa (oteseconazole) is available in the United States.
            When was Vivjoa (oteseconazole) FDA approved?
            Vivjoa (oteseconazole) was FDA approved in April 2022.
            How long does Vivjoa (oteseconazole) stay in your system?
            A long time. It takes about 2 years for most of Vivjoa (oteseconazole) to leave your body. This time-frame is estimated based on the half-life of Vivjoa (oteseconazole). Talk to your prescriber if you have concerns about how long this medication stays in your body.
            Do I need to take Vivjoa (oteseconazole) with food?
            Yes, it's recommended to take Vivjoa (oteseconazole) with food. This is because food causes your body to absorb more of the medication. Take Vivjoa (oteseconazole) at the same time of day or week depending on which dosing step you're on. And try to be consistent with the amount of food you're eating with it. This will help the medication work the best for you.
            How well does Vivjoa (oteseconazole) work?
            In clinical studies, over 90% of people with recurrent vulvovaginal candidiasis who took Vivjoa (oteseconazole) didn't have a vaginal yeast infection for almost a year after taking it. This is compared to around 60% of those who took a placebo pill (a pill that doesn't contain any medication).
            What's the difference between fluconazole (Diflucan) and Vivjoa (oteseconazole)?
            Both fluconazole (Diflucan) and Vivjoa (oteseconazole) are azole antifungal medications that can treat yeast infections. Currently fluconazole (Diflucan) is recommended for 6 months for RVCC after initial therapy. Vivjoa (oteseconazole) is a newer antifungal medication that reduces yeast infections in those with RVVC. Both medications aren't recommended during pregnancy since they haven't been proven to be safe.
            Why can't I take Vivjoa (oteseconazole) if I'm not pregnant now?
            Vivjoa (oteseconazole) shouldn’t be taken in pregnancy or in anyone who can become pregnant. Animal studies showed that high doses of Vivjoa (oteseconazole) in pregnant animals caused harm to unborn babies, including eye damage and death. Because this medication can last in your body for around 2 years after taking it, it's not recommended in people who can get pregnant, even if they aren't pregnant at the time. Vivjoa (oteseconazole) can be taken by those who can't get pregnant, including those who have gone through menopause or those who've had surgeries that prevent them from becoming pregnant (e.g., hysterectomy or tied tubes). Talk to your prescriber if you have questions on whether this medication is right for you.
            Can I take Vivjoa (oteseconazole) if I'm breastfeeding?
            No. Even if you're not pregnant, Vivjoa (oteseconazole) shouldn't be taken if you're breastfeeding. In animal studies, Vivjoa (oteseconazole) caused eye problems in babies when given to mothers during breastfeeding. There isn’t much information about humans taking this medication while breastfeeding, but to be safe, it’s recommended to avoid it.
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            What are the risks and warnings for Vivjoa (oteseconazole)?

            Vivjoa (oteseconazole) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Harm to babies

            People who are of reproductive potential (able to get pregnant), pregnant, or breastfeeding shouldn't take Vivjoa (oteseconazole) because of the risks to unborn babies and breastfed infants. Based on animal studies, Vivjoa (oteseconazole) might cause eye damage including cataracts, trouble seeing, and bleeding in the eyes of unborn babies. The risk is high in those who can get pregnant because Vivjoa (oteseconazole) stays in the body for almost 2 years after taking the last dose. If you haven't gone through menopause or have had surgeries that prevent you from having children, or if you're currently pregnant or breastfeeding, speak with your prescriber about safe options to treat RVVC.

            dosage

            Vivjoa (oteseconazole) dosage forms

            The average cost for 1 carton of 18 capsules of 150mg of Vivjoa (oteseconazole) is $3000.55 with a free GoodRx coupon. This is 13.29% off the average retail price of $3460.63.
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            DosageQuantityPrice as low asPrice per unit
            18 capsules of 150mg1 carton$3000.55$3000.55

            Typical dosing for Vivjoa (oteseconazole)

            Vivjoa (oteseconazole) is either taken by itself or after taking fluconazole (Diflucan). Your prescriber will help you decide the best option for you.

            Vivjoa (oteseconazole) only - dosing lasts a total of 12 weeks

            • Day 1: Take 600 mg (4 capsules) by mouth once.

            • Day 2: Take 450 mg (3 capsules) by mouth once.

            • Starting on Day 14: Take 150 mg (1 capsule) by mouth once a week (every 7 days) for 11 weeks.

            Vivjoa (oteseconazole) and fluconazole (Diflucan): - dosing lasts a total of 14 weeks

            • Day 1: Take 150 mg of fluconazole (Diflucan).

            • Day 4: Take 150 mg of fluconazole (Diflucan).

            • Day 7: Take 150 mg of fluconazole (Diflucan).

            • Days 14 through 20: Take 150 mg (1 capsule) of Vivjoa (oteseconazole) by mouth once a day.

            • Starting on Day 28: Take 150 mg (1 capsule) of Vivjoa (oteseconazole) by mouth once a week (every 7 days) for 11 weeks.

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            How much does Vivjoa (oteseconazole) cost?

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            contraindications-icon

            Vivjoa (oteseconazole) contraindications

            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vivjoa (oteseconazole) will not be safe for you to take.

            • People who are able to become pregnant

            • Currently pregnant

            • Currently breastfeeding

            alternatives

            What are alternatives to Vivjoa (oteseconazole)?

            There are a number of medications that your doctor can prescribe in place of Vivjoa (oteseconazole). Compare a few possible alternatives below.
            Vivjoa (oteseconazole)
            Used for:
            $3000.55 Lowest GoodRx priceView Prices
            Monistat (miconazole)
            Used for:

            • Treatment of vaginal yeast infection

            • Relief of vaginal yeast infection symptoms (itching and irritation outside of the vagina)

            $6.07 Lowest GoodRx priceView Prices
            Fluconazole (Diflucan)
            Used for:
            $1.74 Lowest GoodRx priceView Prices
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            References

            Best studies we found

            American Pregnancy Association. (n.d.). Yeast infection during pregnancy.

            Centers for Disease Control and Prevention. (2021). Vulvovaginal candidiasis (VVC).

            Mao, Q., et al. (2015). Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--An update. The AAPS Journal.

            View All References (5)

            Mycovia Pharmaceuticals, Inc. (2024). Vivjoa- oteseconazole capsule [package insert]. DailyMed.

            Mycovia Pharmaceuticals. (2022). FDA approves Mycovia Pharmaceuticals’ Vivjoa™ (oteseconazole), the first and only FDA-approved medication for recurrent vulvovaginal candidiasis (chronic yeast infection).

            Sobel, J. D., et al. (2021). Oteseconazole: An advance in treatment of recurrent vulvovaginal candidiasis. Future Microbiology.

            Sobel, J. D., et al. (2022). Efficacy and safety of oteseconazole in recurrent vulvovaginal candidiasis. The New England Journal of Medicine Evidence.

            U.S. Food and Drug Administration. (2024). Drug trials snapshots: Vivjoa.

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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