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Varubi Coupon - Varubi 90mg tablet

Varubi

rolapitant
Used for Nausea
Used for Nausea

Varubi (rolapitant) is an antiemetic medication that belongs to the drug class called neurokinin-1 (NK-1) receptor antagonists. It's used for adults to prevent nausea and vomiting caused by certain anticancer medications (chemotherapy). Varubi (rolapitant) is used with two other medications, dexamethasone and a serotonin receptor antagonist. Varubi (rolapitant) is typically given only on day 1 of your chemotherapy cycle. Side effects include low appetite and dizziness.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on November 29, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Varubi (rolapitant)?

What is Varubi (rolapitant) used for?

How Varubi (rolapitant) works

Varubi (rolapitant) is a neurokinin-1 (NK-1) receptor antagonist. It blocks a chemical called substance P from attaching to NK-1 receptors in the brain that control nausea and vomiting. This helps prevent nausea and vomiting from chemotherapy.

Drug Facts

Common BrandsVarubi
Drug ClassNK-1 receptor antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$820.81(save 19.75%)
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$658.69
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What are the side effects of Varubi (rolapitant)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low appetite (9%)
  • Dizziness (6%)
  • Indigestion (4%)
  • Urinary tract infection (UTI, 4%)
  • Inflamed and sore mouth (4%)

Other Side Effects

  • Hiccups
  • Stomach pain

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Varubi (rolapitant)

thumbs-up

Pros

Good option for preventing nausea and vomiting from chemotherapy

Only need to take once per chemotherapy cycle

Can take with or without food

thumbs-down

Cons

Only used to prevent nausea and vomiting, not treat it

Can interact with many medications (e.g., dextromethorphan (Delsym), methotrexate)

Might not be a good option for people with severe liver problems

pharmacist-tips

Pharmacist tips for Varubi (rolapitant)

pharmacist

  • Make sure you understand when you should take Varubi (rolapitant). You should take Varubi (rolapitant) within 2 hours before your chemotherapy on day 1 of your chemotherapy cycle. This timing helps you get the most benefit from the medication to prevent nausea and vomiting from your chemotherapy.

    • Swallow Varubi (rolapitant) whole. Don't crush or chew the tablets. Talk to your provider if you're having trouble swallowing the tablets whole.

      • Don't take Varubi (rolapitant) any more often than once every 2 weeks. Ask your provider about other options if you're still feeling nauseous even after taking Varubi (rolapitant).

        • Varubi (rolapitant) can interact with many medications, such as digoxin (Lanoxin), dextromethorphan (Delsym), and methotrexate. Tell your provider about all the medications you take before you start Varubi (rolapitant). Also, don't start any new medications while you're taking Varubi (rolapitant) without talking to your provider first. Your provider can check that all your medications are safe for you to take.

          faqs

          Frequently asked questions about Varubi (rolapitant)

          When should I take Varubi (rolapitant)?
          Take Varubi (rolapitant) within 2 hours of starting chemotherapy on day 1 of your chemotherapy cycle. You should only take the medication once during each chemotherapy cycle. You can take Varubi (rolapitant) again when it's time for your next chemotherapy cycle. But don't take Varubi (rolapitant) more than one time every 2 weeks.
          How long does Varubi (rolapitant) last?
          Varubi (rolapitant) is a long-lasting medication. It takes about 35 days for most of Varubi (rolapitant) to leave your body after a single dose. This time frame is estimated based on the half-life of Varubi (rolapitant). This is why you typically only need a single dose of Varubi (rolapitant) before each chemotherapy cycle and why you shouldn't take the medication any sooner than every 2 weeks. Talk to your provider if you feel Varubi (rolapitant) isn't working well enough to help prevent nausea and vomiting.
          Does Varubi (rolapitant) cause allergic reactions?
          Studies didn't report anyone having a severe allergic reaction to Varubi (rolapitant) tablets. But it's still a possibility just like with any other medication. Go to the hospital right away if you have symptoms of an allergic reaction after you take Varubi (rolapitant). These symptoms can include rash; hives; shortness of breath; or a swollen throat, tongue, or face.
          Can Varubi (rolapitant) be used in people with a soybean oil allergy?
          Yes, Varubi (rolapitant) can safely be used for people with a soybean oil allergy. Varubi (rolapitant) tablets don't contain any soybean oil.
          Is Varubi (rolapitant) available as an injection?
          No, Varubi (rolapitant) is currently only available as a tablet. The medication used to be available as an intravenous (IV) injection, but the IV form was discontinued. In January 2018, the FDA and the manufacturer issued a warning stating that some people who were given the IV form of Varubi (rolapitant) had serious allergic reactions, including anaphylaxis and other allergic reactions that needed hospitalization. These reactions happened during or very soon after people got their Varubi (rolapitant) infusion.
          Can Varubi (rolapitant) be used in children?
          It's not known if Varubi (rolapitant) is safe or or if it works well in children younger than 18 years old. Varubi (rolapitant) shouldn't be used for children under 2 years old because the medication affected the sexual development and fertility (ability to have babies) of young rats in animal studies. Ask your child's provider for other options to prevent nausea and vomiting from chemotherapy for your child.
          Can I use Varubi (rolapitant) if I'm pregnant?
          Talk to your provider to see if Varubi (rolapitant) is right for you if you're pregnant or thinking of getting pregnant. Your provider will discuss your options with you. There haven't been enough studies looking at how the medication affects mothers and babies during pregnancy. Because of this, it's not known if Varubi (rolapitant) is safe to use during pregnancy. In studies done on animals, Varubi (rolapitant) didn't cause harm to unborn babies, but it affected the ability to have babies in female rats. Note that what happens in animals doesn't always mean that it'll happen in humans.
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          What are the risks and warnings for Varubi (rolapitant)?

          Varubi (rolapitant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Interactions with other medications

          Varubi (rolapitant) interacts with many medications. It can change the level of other medications in your blood. This can lead to serious side effects. Some medications, like pimozide (Orap) and thioridazine, can't be used at all with Varubi (rolapitant). Other medications will need to have their dose adjusted; you'll also need to watch more closely for side effects if you have to take them with Varubi (rolapitant).

          Make sure to tell your provider about all the medications you're taking before you take Varubi (rolapitant). Don't start any new medications while you're taking Varubi (rolapitant) without talking to your provider or pharmacist first.

          dosage

          Varubi (rolapitant) dosage forms

          The average cost for 2 tablets of 90mg of Varubi (rolapitant) is $658.69 with a free GoodRx coupon. This is 19.75% off the average retail price of $820.81.
          tablet
          Tablet
          DosageQuantityPrice as low asPrice per unit
          90mg2 tablets$658.69$329.35

          Typical dosing for Varubi (rolapitant)

          The typical dose is 180 mg by mouth within 2 hours before starting chemotherapy on day 1 of each chemotherapy cycle. Varubi (rolapitant) shouldn't be taken any sooner than every 2 weeks.

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          How much does Varubi (rolapitant) cost?

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          contraindications-icon

          Varubi (rolapitant) contraindications

          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Varubi (rolapitant) will not be safe for you to take.
          alternatives

          What are alternatives to Varubi (rolapitant)?

          There are a number of medications that your doctor can prescribe in place of Varubi (rolapitant). Compare a few possible alternatives below.
          Varubi (rolapitant)
          Used for:
          $658.69 Lowest GoodRx priceView Prices
          Emend (aprepitant)
          Used for:
          $32.14 Lowest GoodRx priceView Prices
          Akynzeo (netupitant / palonosetron)
          Used for:

          • Prevention of acute and delayed nausea and vomiting caused by certain chemotherapy when used together with dexamethasone

          $702.34 Lowest GoodRx priceView Prices
          images

          Varubi (rolapitant) images

          Blue Oblong 100 And T0101 - VARUBI 90mg Tablet
          This medicine is Blue, Oblong Tablet Imprinted With "T0101" And "100".Blue Oblong 100 And T0101 - VARUBI 90mg Tablet

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          References

          Best studies we found

          American College of Allergy, Asthma, & Immunology. (2018). Drug allergies.

          Drugs@FDA: FDA-Approved Drugs. (n.d.). Rolapitant hydrochloride. U.S. Food and Drug Administration.

          Ibrahim, M. A., et al. (2022). Antiemetic neurokinin-1 receptor blockers. StatPearls.

          View All References (3)

          National Cancer Institute. (2023). Nausea and vomiting related to cancer treatment (PDQ®)–Health professional version.

          TerSera Therapeutics LLC. (2020). Varubi- rolapitant tablet [package insert]. DailyMed.

          Tesaro, Inc. (2018). Important drug warning; important prescribing information.

          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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