What is Vanrafia?

They need to know if you have any of these conditions:

• Heart failure
• Liver disease
• An unusual or allergic reaction to atrasentan, other medications, food, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

Take this medication by mouth. Take it as directed on the prescription label at the same time each day. Do not cut, crush, or chew this medication. Swallow the tablets whole. Take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

If you miss a dose, skip it. Take your next dose at the normal time. Do not take double or extra doses.

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original container. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.