Compare
Vanrafia vs. Filspari

Vanrafia (atrasentan) is a medication used to lower protein levels in the urine in adults with immunoglobulin A nephropathy (IgAN). It works as an endothelin receptor antagonist to help reduce stress on the kidneys. Vanrafia (atrasentan) comes as a tablet that’s taken by mouth once a day. Common side effects include swelling in the arms or legs and low red blood cells.

• Lowering the amount of protein in the urine in adults with immunoglobulin A nephropathy (IgAN)

• Swelling of the arms or legs (10%)
• Low red blood cells (anemia, 6%)

• Harmful during pregnancy
• Liver damage
• Too much fluid buildup in the body
• Lower sperm counts

Filspari (sparsentan) is a medication that works well to lower urine protein levels in people with immunoglobulin A nephropathy (IgAN). It's not known if this means Filspari (sparsentan) slows down worsening kidney function, but this is something that's currently being studied. Filspari (sparsentan) is taken by mouth, typically once daily. Some of the more common side effects it can cause include swelling in the arms and legs, low blood pressure, and dizziness.

• Lower urine protein levels in adults with immunoglobulin A nephropathy (IgAN)

• Swelling in arms or legs (14%)
• Low blood pressure (14%)
• Dizziness (13%)
• High blood potassium levels (13%)

• Serious liver damage
• Not for use during pregnancy
• Dangerously low blood pressure
• Serious kidney damage
• High potassium levels
• Too much fluid