Vanrafia vs. Filspari for Kidney Disease: Important Differences and Potential Risks.

Vanrafia

(atrasentan)

Filspari

(sparsentan)

Summary for Vanrafia

Prescription only

Vanrafia (atrasentan) is a medication used to lower protein levels in the urine in adults with immunoglobulin A nephropathy (IgAN). It works as an endothelin receptor antagonist to help reduce stress on the kidneys. Vanrafia (atrasentan) comes as a tablet that’s taken by mouth once a day. Common side effects include swelling in the arms or legs and low red blood cells.

Indications for Vanrafia

Lowering the amount of protein in the urine in adults with immunoglobulin A nephropathy (IgAN)

Pros and Cons for Vanrafia

Pros

Only taken once a day
Can take it with or without food
Can take it with other common medications that help with kidney problems

Cons

Unknown whether it can slow the worsening of kidney function
Commonly causes swelling in your arms or legs
Not safe to take while pregnant

Common Side Effects for Vanrafia

Swelling of the arms or legs (10%)
Low red blood cells (anemia, 6%)

Warnings for Vanrafia

Harmful during pregnancy
Liver damage
Too much fluid buildup in the body
Lower sperm counts

Summary for Filspari

Prescription only

Filspari (sparsentan) is a medication that works well to lower urine protein levels in people with immunoglobulin A nephropathy (IgAN). It's not known if this means Filspari (sparsentan) slows down worsening kidney function, but this is something that's currently being studied. Filspari (sparsentan) is taken by mouth, typically once daily. Some of the more common side effects it can cause include swelling in the arms and legs, low blood pressure, and dizziness.

Indications for Filspari

Lower urine protein levels in adults with immunoglobulin A nephropathy (IgAN)

Pros and Cons for Filspari

Pros

Works better at lowering urine protein levels than irbesartan (Avapro), an existing IgAN treatment option
Taken by mouth
Taken once daily

Cons

More studies needed to show Filspari (sparsentan) can slow the worsening of kidney problems
Not a cure for IgAN
Can cause dangerously low blood pressure
Not studied in children

Common Side Effects for Filspari

Swelling in arms or legs (14%)
Low blood pressure (14%)
Dizziness (13%)
High blood potassium levels (13%)

Warnings for Filspari

Serious liver damage
Not for use during pregnancy
Dangerously low blood pressure
Serious kidney damage
High potassium levels
Too much fluid

Prices with our coupons for Vanrafia vs. Filspari

Vanrafia30 tablets / 0.75mg

$15,271.39-

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Filspari30 tablets / 400mg

$14,069.55-

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Vanrafia vs. Filspari

Vanrafia

Filspari

Summary for Vanrafia

Indications for Vanrafia

Pros and Cons for Vanrafia

Pros

Cons

Common Side Effects for Vanrafia

Warnings for Vanrafia

Summary for Filspari

Indications for Filspari

Pros and Cons for Filspari

Pros

Cons

Common Side Effects for Filspari

Warnings for Filspari

Prices with our coupons for Vanrafia vs. Filspari

Browse medications by letter

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Vanrafia

Filspari

Summary for Vanrafia

Indications for Vanrafia

Pros and Cons for Vanrafia

Pros

Cons

Common Side Effects for Vanrafia

Warnings for Vanrafia

Summary for Filspari

Indications for Filspari

Pros and Cons for Filspari

Pros

Cons

Common Side Effects for Filspari

Warnings for Filspari