Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Vanrafia vs. Filspari

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Vanrafia (atrasentan)
    Filspari (sparsentan)
  • Vanrafia (atrasentan)
    Filspari (sparsentan)

  • Summary of Vanrafia vs. Filspari

    Summary for Endothelin receptor antagonist
    Prescription only

    Vanrafia (atrasentan) is a medication used to lower protein levels in the urine in adults with immunoglobulin A nephropathy (IgAN). It works as an endothelin receptor antagonist to help reduce stress on the kidneys. Vanrafia (atrasentan) comes as a tablet that’s taken by mouth once a day. Common side effects include swelling in the arms or legs and low red blood cells.

    Summary for Endothelin receptor antagonist and angiotensin II receptor blocker
    Prescription only

    Filspari (sparsentan) is a medication that works well to lower urine protein levels in people with immunoglobulin A nephropathy (IgAN). It's not known if this means Filspari (sparsentan) slows down worsening kidney function, but this is something that's currently being studied. Filspari (sparsentan) is taken by mouth, typically once daily. Some of the more common side effects it can cause include swelling in the arms and legs, low blood pressure, and dizziness.

  • Indications of Vanrafia vs. Filspari

    Indications for
    •Lowering the amount of protein in the urine in adults with immunoglobulin A nephropathy (IgAN)
    Indications for
    •Lower urine protein levels in adults with immunoglobulin A nephropathy (IgAN)

  • Pros and Cons of Vanrafia vs. Filspari

    Pros and Const for Endothelin receptor antagonist
    Pros
    •Only taken once a day
    •Can take it with or without food
    •Can take it with other common medications that help with kidney problems
    Cons
    •Unknown whether it can slow the worsening of kidney function
    •Commonly causes swelling in your arms or legs
    •Not safe to take while pregnant
    Pros and Const for Endothelin receptor antagonist and angiotensin II receptor blocker
    Pros
    •Works better at lowering urine protein levels than irbesartan (Avapro), an existing IgAN treatment option
    •Taken by mouth
    •Taken once daily
    Cons
    •More studies needed to show Filspari (sparsentan) can slow the worsening of kidney problems
    •Not a cure for IgAN
    •Can cause dangerously low blood pressure
    •Not studied in children

  • Common Side Effects of Vanrafia vs. Filspari

    Common Side Effects for
    •Swelling of the arms or legs (10%)
    •Low red blood cells (anemia, 6%)
    Common Side Effects for
    •Swelling in arms or legs (14%)
    •Low blood pressure (14%)
    •Dizziness (13%)
    •High blood potassium levels (13%)

  • Warnings of Vanrafia vs. Filspari

    Common Side Effects for
    •Harmful during pregnancy
    •Liver damage
    •Too much fluid buildup in the body
    •Lower sperm counts
    Common Side Effects for
    •Serious liver damage
    •Not for use during pregnancy
    •Dangerously low blood pressure
    •Serious kidney damage
    •High potassium levels
    •Too much fluid

  • Prices with our coupons for Vanrafia vs. Filspari

    Learn more about Vanrafia
    Learn more about Filspari

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.