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Tramadol / Acetaminophen Coupon - Tramadol / Acetaminophen 37.5mg/325mg tablet

tramadol / acetaminophen

Generic Ultracet
Used for Pain
Used for Pain

Ultracet (tramadol / acetaminophen) is a combination pain medication that should only be used for pain that hasn't responded to other alternatives. It's only used for short-term pain, so it should be taken for no more than 5 days.

Last reviewed on June 17, 2021
Ultracet (tramadol / acetaminophen) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Ultracet (tramadol / acetaminophen)?

What is Ultracet (tramadol / acetaminophen) used for?

  • Acute (short-term) pain

How Ultracet (tramadol / acetaminophen) works

Ultracet (tramadol / acetaminophen) is a combination pain medication that contains tramadol (an opioid) and acetaminophen (an analgesic). It's unclear how tramadol works in the treatment of pain, but it's thought that its activities with the mu-opioid receptor and effects on serotonin and norepinephrine levels in the brain may lower your perception (awareness) of pain. Acetaminophen relieves pain and lowers fevers by stopping the production of certain chemicals in the brain that cause both pain and fever.

Are you looking for information on tramadol (Ultram) or acetaminophen (Tylenol) instead?

Drug Facts

Common BrandsUltracet
Drug ClassOpioid / Analgesic
Controlled Substance ClassificationSchedule IV
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Ultracet (tramadol / acetaminophen)?

Ultracet (tramadol / acetaminophen) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Addiction, abuse, and misuse

  • Risk factors: Mental health conditions (e.g., depression) | History of or family history of substance abuse

    Ultracet (tramadol / acetaminophen) has a risk of addiction, abuse, and misuse. Your body can develop tolerance to Ultracet (tramadol / acetaminophen), which means that more medication is needed to treat the same pain. You may become physically dependent on Ultracet (tramadol / acetaminophen) if you have been using it continuously, which means that you'll feel withdrawal symptoms if you stop taking it suddenly. Take only the prescribed dose. People with a history of substance abuse shouldn't take Ultracet (tramadol / acetaminophen) if an alternative medication is available.

    risk-warning

    Medication education programs

    Since Ultracet (tramadol / acetaminophen) can cause potentially life-threatening and deadly side effects, the manufacturers are required to provide healthcare providers with the resources to prescribe this medication properly and safely. Your provider or pharmacist will discuss the risks and benefits with taking Ultracet (tramadol / acetaminophen) before you start the medication.

    risk-warning

    Life-threatening breathing problems

    • Risk factors: People age 65 or older | People who are severely ill | Lung disease

      Ultracet (tramadol / acetaminophen) can cause irregular or slowed breathing that can put you in a coma and can even cause death. Don't take more than what your provider prescribed to you. Always check with your provider before starting any new medications or supplements. Make sure to take special precautions to store this medication in a safe place away from the reach of children. If a child accidentally uses this medication, they may overdose, develop breathing problems, and potentially have a deadly outcome. If this happens, call the poison control center right away at 1-800-222-1222.

      risk-warning

      Slowed breathing in children

      • Risk factors: Children with obstructive sleep apnea or lung disease | Children who are obese | Adenoid or tonsil surgery in children

        Some people have a gene that causes them to process Ultracet (tramadol / acetaminophen) too fast. Children who have this gene can be especially sensitive to this quick metabolism (breakdown) of Ultracet (tramadol / acetaminophen), which can result in slowed breathing and even death. Deadly breathing problems have also occurred in children who received Ultracet (tramadol / acetaminophen) following removal of their tonsils or adenoids. This medication shouldn't be used in children younger than 12 years old or children between 12 and 18 years old who are at high risk for breathing problems.

        risk-warning

        Withdrawal in infants

        • Risk factors: Long-term use of Ultracet (tramadol / acetaminophen) during pregnancy

          There is a high risk that your newborn baby could develop withdrawal symptoms if you've been using Ultracet (tramadol / acetaminophen) for a long period of time during pregnancy. These withdrawal symptoms can be deadly for infants. If you're pregnant or think you may be pregnant, discuss with your provider about all of the risks that are associated with this medication before starting it.

          risk-warning

          Dangerous interactions with other medications and alcohol

          Ultracet (tramadol / acetaminophen) can interact with other medications, which can change how it affects your body and pain overall. Some medications can increase the levels of Ultracet (tramadol / acetaminophen) in your body and cause potentially deadly respiratory depression (slowed breathing). Other medications can lower the levels of Ultracet (tramadol / acetaminophen) in your body and lead to poor control of your pain. Some examples of medications that might interact with Ultracet (tramadol / acetaminophen) include, certain anbiotics, antifungals, and medications used for anxiety or depression. It's also very important to avoid alcohol while on this medication, because the combination can lead to serious side effects such as slowed breathing, low blood pressure, and extreme sedation. While taking Ultracet (tramadol / acetaminophen), don't start any new prescription or over-the-counter medications until confirming with your provider or pharmacist that it is safe to do so.

          risk-warning

          Liver damage

          • Risk factors: Taking more than 4 grams of acetaminophen a day | Taking multiple products containing acetominophen

            Acetaminophen, which is in Ultracet (tramadol / acetaminophen), has been associated with liver failure. You are at higher risk if you're taking more than one product containing acetaminophen and taking more than 4 grams a day. If you suspect that you took more than this maximum daily dose, get medical help right away, even if you're feeling okay.

            risk-warning

            Increased serotonin levels (serotonin syndrome)

            • Risk factors: Using other medications that affect serotonin | Using monoamine oxidase inhibitors (MAOIs) within 14 days of Ultracet (tramadol / acetaminophen)

              Serotonin syndrome is a rare, but potentially life-threatening condition caused by higher levels of serotonin in the brain. Your risk goes up if you use Ultracet (tramadol / acetaminophen) with other medications that affect serotonin, such as antidepressants, lithium, triptans, and St. John's wort. Symptoms of serotonin syndrome include fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion. If you notice any of these symptoms, get medical attention right away.

              risk-warning

              Seizures

              • Risk factors: History of seizures | Taking with antidepressants, medications that can cause seizures, or other opioids

                Ultracet (tramadol / acetaminophen) can raise your risk of seizures. If you have a history of seizures, taking medications that can cause seizures, or have risk factors for getting seizures, let your provider know so that they can monitor for new or worsening of symptoms.

                risk-warning

                Suicide risk

                Ultracet (tramadol / acetaminophen) shouldn't be given to people who have a history of substance or alcohol abuse, or to people who are depressed or suicidal, because this medication can worsen those problems.

                risk-warning

                Adrenal problems

                • Risk factors: Using Ultracet (tramadol / acetaminophen) for more than a month

                  Ultracet (tramadol / acetaminophen) can cause your adrenal glands to not make the right amount of hormones for your body to function properly. If you experience nausea, vomiting, loss of appetite, fatigue, weakness, dizziness, and low blood pressure while taking this medication, let your provider know. Your provider may need to do a proper exam to rule out adrenal problems.

                  risk-warning

                  Low blood pressure

                  Ultracet (tramadol / acetaminophen) can cause a sudden drop in your blood pressure. You may feel dizzy and lightheaded. If you're sensitive to low blood pressures, change positions slowly, such as going from sitting to standing. If you always get low blood pressure symptoms, you may need to try a different pain medication.

                  risk-warning

                  Head or brain injuries

                  People who have brain or head injuries are at higher risk of developing extreme sedation and breathing problems while taking Ultracet (tramadol / acetaminophen). Let your provider know about all of your medical conditions before starting this medication.

                  risk-warning

                  Digestive tract blockage

                  If you have certain stomach conditions or digestive tract blockage, don't use Ultracet (tramadol / acetaminophen), because it can worsen your problems. Let your provider know if you experience stomach pain, feeling of fullness in your stomach, or extreme constipation while taking this medication.

                  risk-warning

                  Withdrawal symptoms

                  • *Risk factors: Abrupt discontinuation of

                    Ultracet (tramadol / acetaminophen)*

                    Ultracet (tramadol / acetaminophen) shouldn't be used for more than 5 days. If you are instructed by your provider to take this medication for longer than 5 days, don't stop taking it all of a sudden on your own. Doing so can cause withdrawal symptoms and the return of your pain. Withdrawal symptoms can include restlessness, yawning, chills, nausea, vomiting, diarrhea, and increased irritability. Your provider will work with your to lower your dose slowly to avoid side effects.

                    risk-warning

                    Driving and operating machinery

                    Ultracet (tramadol / acetaminophen) can affect your abilities to think, focus, and react. Be careful driving, operating machinery, or doing any dangerous activities until you know how this medication affects you.

                    risk-warning

                    Serious allergic reactions

                    Ultracet (tramadol / acetaminophen) can cause serious and potentially life-threatening allergic reactions. If you experience hives, swelling of your face, throat, or tongue, or difficulty breathing while taking this medication, get medical help right away. You will need to stop taking Ultracet (tramadol / acetaminophen) and switch to a different medication.

                    risk-warning

                    Serious skin reactions

                    In some rare cases, Ultracet (tramadol / acetaminophen) can cause serious skin reactions. If you notice a rash, blisters, or skin peeling after taking Ultracet (tramadol / acetaminophen), you should stop using it right away and get medical attention as quickly as possible.

                    basics-icon

                    What are the side effects of Ultracet (tramadol / acetaminophen)?

                    The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                    Common Side Effects

                    • Constipation (6%)
                    • Sleepiness (6%)
                    • Increased sweating (4%)
                    • Diarrhea (3%)
                    • Nausea (3%)
                    • Poor appetite (3%)
                    • Dizziness (3%)

                    Other Side Effects

                    • Dry mouth
                    • Stomach pain
                    • Indigestion or upset stomach
                    • Weakness
                    • Fatigue
                    • Headache
                    • Anxiety
                    • Shakiness
                    • Trouble sleeping
                    • Itching
                    • Prostate problems

                    Serious Side Effects

                    Contact your healthcare provider immediately if you experience any of the following.
                    • __Trouble breathing __
                    • Fast heartbeat
                    • Chest pain
                    • Swelling of your face, tongue or throat
                    • Extreme sleepiness
                    • Increased irritability
                    • Increased body temperature
                    • Trouble walking
                    • Stiff muscles
                    • Mental changes, such as confusion

                    Source: DailyMed

                    The following side effects have also been reported

                    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                    Check with your doctor immediately if any of the following side effects occur:

                    Rare

                    Burning, itching, and redness of the skin

                    chest pain or tightness

                    cough

                    difficulty with swallowing

                    dizziness

                    fast heartbeat

                    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

                    seizures

                    skin rash, hives, or itching skin

                    trouble breathing

                    unusual tiredness or weakness

                    vomiting

                    Incidence not known

                    Agitation

                    bigger, dilated, or enlarged pupils

                    blistering, peeling, or loosening of the skin

                    chills

                    confusion

                    confusion as to time, place, or person

                    constricted, pinpoint, or small pupils

                    darkening of the skin

                    diarrhea

                    fainting

                    fever

                    hallucinations

                    holding false beliefs that cannot be changed by fact

                    increased sensitivity of the eyes to light

                    irregular or slow heart rate

                    joint or muscle pain

                    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

                    loss of appetite

                    nausea

                    noisy breathing

                    overactive reflexes

                    poor coordination

                    red skin lesions, often with a purple center

                    red, irritated eyes

                    shivering

                    sore throat

                    sores, ulcers, or white spots in the mouth or on the lips

                    sweating

                    talking or acting with excitement you cannot control

                    trembling or shaking

                    twitching

                    unusual excitement, nervousness, or restlessness

                    Get emergency help immediately if any of the following symptoms of overdose occur:

                    Symptoms of overdose

                    Black, tarry stools

                    dark urine

                    depression

                    disorientation

                    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

                    drowsiness to profound coma

                    fever

                    headache

                    irregular, fast or slow, or shallow breathing

                    lightheadedness

                    loss of appetite

                    mood or other mental changes

                    nausea

                    pale or blue lips, fingernails, or skin

                    seeing, hearing, or feeling things that are not there

                    stomach pain

                    trouble sleeping

                    unpleasant breath odor

                    unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

                    vomiting of blood

                    yellow eyes or skin

                    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                    Less common

                    Anxiety

                    belching

                    bloated or feeling of fullness

                    constipation

                    dry mouth

                    excess air or gas in the stomach or bowels

                    false or unusual sense of well-being

                    feeling of warmth

                    heartburn

                    increase in bowel movements

                    increased sweating

                    indigestion

                    loose stools

                    loss of strength or energy

                    muscle pain or weakness

                    numbness or tingling of the hands, legs, and feet

                    painful or difficult urination

                    redness of the face, neck, arms, and occasionally the upper chest

                    sleepiness or unusual drowsiness

                    soft stools

                    stomach discomfort

                    weight loss

                    Rare

                    Abnormal thinking

                    blurred vision

                    change in vision

                    clumsiness, unsteadiness, trembling, or problems with muscle control or coordination

                    cold sweats

                    continuing ringing, buzzing, or unexplained noise in the ears

                    crying

                    decrease in the frequency or amount of urination

                    decreased awareness or responsiveness

                    decreased interest in sexual intercourse

                    delusions of persecution, mistrust, suspiciousness, or combativeness

                    difficulty in passing urine (dribbling)

                    false or unusual sense of well-being

                    feeling of constant movement of self or surroundings

                    feeling unusually cold

                    headache, severe or continuing

                    increased muscle tone

                    involuntary muscle contractions

                    loss of memory

                    loss of sense of reality

                    loss of sexual ability, desire, drive, or performance

                    migraine headache

                    morbid dreaming

                    pounding in the ears

                    problems with memory

                    quick to react or overreact emotionally

                    rapidly changing moods

                    sensation of spinning

                    severe stomach pain

                    shakiness and unsteady walk

                    shivering

                    vomiting of blood or material that looks like coffee grounds

                    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                    pros-and-cons

                    Pros and cons of Ultracet (tramadol / acetaminophen)

                    thumbs-up

                    Pros

                    Two pain medications conveniently combined into one tablet to provide pain relief

                    Has a lower chance of causing breathing problems compared to stronger opioid pain medications

                    Doesn't cause as much constipation compared to other opioid pain medications

                    Pain relief kicks in faster than using tramadol (Ultram) alone

                    Pain relief lasts longer than using acetaminophen (Tylenol) alone

                    Generic available, making it more affordable

                    thumbs-down

                    Cons

                    Only used for short-term treatment of pain (less than 5 days)

                    Has to be taken multiple times a day

                    Has a risk of addiction and abuse

                    While taking Ultracet (tramadol / acetaminophen), you need to keep track of the total amount of acetaminophen (Tylenol) you are taking to avoid liver damage.

                    Not best option for people with liver problems

                    pharmacist-tips

                    Pharmacist tips for Ultracet (tramadol / acetaminophen)

                    pharmacist
                    • There are several prescription and over-the-counter (OTC) medications that contain acetaminophen (Tylenol). This can become a problem when taking Ultracet (tramadol / acetaminophen) because this combination medication also contains acetaminophen. If you're not sure if the medications you're taking contain acetaminophen, ask your provider or pharmacist. Limit the amount of acetaminophen you take per day to avoid any damage to your liver.

                      • Ultracet (tramadol / acetaminophen) should only be used for 5 days or less for acute (short-term) pain. There is a risk for addiction, abuse, and misuse with this medication. Therefore, try to take the lowest dose for the shortest amount of time that's needed to treat your pain.

                        • Ultracet (tramadol / acetaminophen) can make you sleepy. Avoid driving or other tasks that require you to be alert until you know how this medication affects you.

                          • Don't take Ultracet (tramadol / acetaminophen) with alcohol. The acetaminophen component of Ultracet (tramadol / acetaminophen) can cause liver damage, and alcohol can raise this risk. Additionally, taking Ultracet (tramadol / acetaminophen) with alcohol can raise your risk of extreme sedation (drowsiness), breathing problems, coma, and even death.

                            • Ultracet (tramadol / acetaminophen) can cause a sudden drop in blood pressure when changing positions, such as from sitting to standing. This is especially common when you first start Ultracet (tramadol / acetaminophen) and when the dose is changed. Be careful when changing positions to avoid falling and hurting yourself.

                              faqs

                              Frequently asked questions about Ultracet (tramadol / acetaminophen)

                              Is Ultracet (tramadol / acetaminophen) the same thing as tramadol (Ultram)?
                              No, Ultracet (tramadol / acetaminophen) is not quite the same thing as tramadol (Ultram). Ultracet (tramadol / acetaminophen) is a combination medication that contains both tramadol and acetaminophen, whereas tramadol is just one ingredient. While taking Ultracet (tramadol / acetaminophen), it's important to avoid any other tramadol- or acetaminophen-containing products, because you may take too much of either ingredient, which raises your risk of side effects.
                              Do I take Ultracet (tramadol / acetaminophen) with food?
                              You can take Ultracet (tramadol / acetaminophen) with food if you have an upset stomach or nausea after taking it. When taken with food, Ultracet (tramadol / acetaminophen) may take a little bit longer to kick in. However, you'll still eventually absorb the same amount of medication, but the pain relief just make take longer to achieve.
                              Can I take Ultracet (tramadol / acetaminophen) with ibuprofen (Advil, Motrin)?
                              Ultracet (tramadol / acetaminophen) can be taken with ibuprofen (Advil, Motrin), if needed. Instead of taking them at the same time, try alternating them with each other so you give each medication time to kick in. With this being said, you should always consult with your provider or pharmacist before starting any new medications while taking Ultracet (tramadol / acetaminophen).
                              How fast does Ultracet (tramadol / acetaminophen) work?
                              Ultracet (tramadol / acetaminophen) starts working in less than 1 hour after taking it. If you take it with food, it may take longer to start to work.
                              Can Ultracet (tramadol / acetaminophen) make you sleepy?
                              Yes, Ultracet (tramadol / acetaminophen) can make you sleepy. Avoid driving or doing anything that requires full alertness until you know how this medication affects you.
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                              dosage

                              Ultracet (tramadol / acetaminophen) dosage forms

                              The average cost for 60 tablets of 37.5mg/325mg of Ultracet (tramadol / acetaminophen) is $34.29 with a free GoodRx coupon. This is 54.96% off the average retail price of $76.12.
                              tablet
                              Tablet
                              DosageQuantityPrice as low asPrice per unit
                              37.5mg/325mg12 tablets$34.29$2.86

                              Typical dosing for Ultracet (tramadol / acetaminophen)

                              Your provider will work with you to prescribe the right dose of Ultracet (tramadol / acetaminophen) for your individual needs. It's recommended to use the lowest dose possible for the shortest duration of time to manage your pain.

                              In general, the starting dose is 2 tablets by mouth every 4 to 6 hours as needed for pain.

                              Each tablet contains 37.5 mg of tramadol and 325 mg of acetaminophen.

                              interactions

                              Interactions between Ultracet (tramadol / acetaminophen) and other drugs

                              Ultracet (tramadol / acetaminophen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Ultracet (tramadol / acetaminophen). Please note that only the generic name of each medication is listed below.

                              Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                              Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                              drug-cost

                              How much does Ultracet (tramadol / acetaminophen) cost?

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                              alternatives

                              What are alternatives to Ultracet (tramadol / acetaminophen)?

                              There are a number of medications that your doctor can prescribe in place of Ultracet (tramadol / acetaminophen). Compare a few possible alternatives below.
                              Ultracet (tramadol / acetaminophen)
                              Used for:
                              • Acute (short-term) pain

                              $34.29 Lowest GoodRx priceView Prices
                              Used for:
                              • Pain that isn't relieved by non-opioid pain medications alone

                              $20.41 Lowest GoodRx priceView Prices
                              Used for:
                              $6.17 Lowest GoodRx priceView Prices
                              images

                              Ultracet (tramadol / acetaminophen) images

                              Yellow Round M And P / T - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              This medicine is Yellow, Round Tablet Imprinted With "M" And "P / T".Yellow Round M And P / T - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              Yellow Oblong I03 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              This medicine is Yellow, Oblong Tablet Imprinted With "I03".Yellow Oblong I03 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              Beige Oblong An 617 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              This medicine is Beige, Oblong Tablet Imprinted With "An 617".Beige Oblong An 617 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              Yellow Oblong 537 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              This medicine is Yellow, Oblong Tablet Imprinted With "537".Yellow Oblong 537 - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              Yellow Oblong 37.5-325 And Apo - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet
                              This medicine is Yellow, Oblong Tablet Imprinted With "Apo" And "37.5-325".Yellow Oblong 37.5-325 And Apo - Tramadol Hydrochloride / Acetaminophen 37.5mg-325mg Tablet

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