Who makes Tryptyr (acoltremon)?

Tryptyr (acoltremon) is manufactured by [Alcon Laboratories, Inc](https://investor.alcon.com/news-and-events/press-releases/news-details/2025/Alcon-Announces-FDA-Approval-of-TRYPTYR-acoltremon-ophthalmic-solution-0-003-for-the-Treatment-of-the-Signs-and-Symptoms-of-Dry-Eye-Disease/default.aspx).

Tryptyr

acoltremon

Used for Dry Eye

Tryptyr (acoltremon) is an eye drop used to treat the signs and symptoms of dry eye disease. It's approved for adults with long-term (chronic) dry eye. This medication belongs to the TRPM8 agonist drug class. It comes as preservative‑free, single‑use vials. You place a drop in each eye twice a day (about 12 hours apart). The most common side effect is a brief burning or stinging feeling when the drop goes in.

Reviewed by:

Kristianne Hannemann, PharmD

Cydnee Ng, PharmD

Last reviewed on May 13, 2026

What is Tryptyr (acoltremon)?

What is Tryptyr (acoltremon) used for?

Dry eye in adults

How Tryptyr (acoltremon) works

Tryptyr (acoltremon) is a TRPM8 thermoreceptor agonist. The exact way the medication works to relieve symptoms of dry eye disease isn’t fully known.

It's thought to act on cold‑sensing receptors called TRPM8 on the surface of the eye. This sends signals to your body to boost your natural tear production. This helps keep the eye surface moist and comfortable.

When does Tryptyr (acoltremon) start working?Time passed since treatment started:

HOURS

DAYS

Initial effect

WEEKS

Full effect

MONTHS

Drug facts

Common Brands	Tryptyr
Drug Class	TRPM8 receptor agonist
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Prescription only

Common Brands

Tryptyr

Drug Class

TRPM8 receptor agonist

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Prescription only

Side effects of Tryptyr (acoltremon)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Pain when placing the drop into the eye (50%)

When do Tryptyr (acoltremon) possible side effects begin and end?

Time passed since treatment started:

MMINUTES

HHOURS

DDAYS

WWEEKS

MMONTHS

Pain in the eye (burning or stinging)

Source: DailyMed

The following Tryptyr (acoltremon) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
New or worsening eye pain, redness, irritation, or discharge

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Burning or stinging of the eyes after use

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Avg retail price

$1058.76(Save 19.62%)

$851.05

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Pros and cons of Tryptyr (acoltremon)

Pros

Preservative‑free single‑use vials
Can help improve tear production within 2 weeks of regular use
Can be used with other eye drops if spaced by at least 5 minutes

Cons

Works best when used every day
Brief burning or stinging is common
Not approved for children

Pharmacist tips for Tryptyr (acoltremon)

Use Tryptyr (acoltremon) twice a day, about 12 hours apart. Setting phone reminders can help you remember when to use the medication.
If you miss a dose of Tryptyr (acoltremon), just wait for the next dose at your usual time. Don’t double up.
If you wear contact lenses, take them out before using Tryptyr (acoltremon). Then, wait at least 15 minutes before putting them back in after using the drops.
Tryptyr (acoltremon) is preservative‑free and comes in single‑dose vials for one‑time use. Using a fresh vial each time helps lower infection risk and avoids contamination. There's enough liquid in each vial for both eyes.
How to use Tryptyr (acoltremon): Wash your hands, then open one foil pouch and remove one vial. Hold the vial upright and twist off the tab at the top. Then, tilt your head back or lie down, pull down your lower lid, and look up. Place the tip of the vial very close (but not touching) your eye. Squeeze one full drop into your eye. If a drop misses, try again. Then, close your eye gently for a few seconds. Repeat for your other eye. Throw away the vial right after using for both eyes.
Burning or stinging is common after using Tryptyr (acoltremon) and it's usually brief. If the pain is severe or doesn’t fade, stop using the medication and tell your prescriber.
Keep using Tryptyr (acoltremon) as directed, even if your symptoms improve. In studies, dry eye symptoms got better within 2 weeks, though some people felt relief sooner. These improvements stayed stable over 3 months of regular use. That's why it's important to use the eye medication every day.
If you use other eye drops, wait at least 5 minutes between those and Tryptyr (acoltremon). This helps each drop absorb well into your eye and keeps them from washing each other out. Ask your prescriber or pharmacist if you need help planning how to space out each eye medication.
Don’t touch the Tryptyr (acoltremon) vial tip to your eye, with your fingers, or to any surface. This prevents germs from getting into the medication and possibly into your eye. It also helps you avoid hurting your eye with the plastic tip.

How to store Tryptyr (acoltremon):

Store unopened cartons in the refrigerator between 36°F and 46°F. After opening it, you can keep it refrigerated or at room temperature (36°F to 77°F). If stored at room temperature, use it within 30 days or before the expiration date (whichever comes first). Write the date you opened it on the carton.
After you open a Tryptyr (acoltremon) foil pouch, use the vials inside within 7 days. Write down the date you opened the pouch so you remember when to use the vials by. Always keep unused vials in the original pouch until you're ready, and never reuse a vial.
Don't keep Tryptyr (acoltremon) in places warmer than 77°F. This includes inside a car, outside, or in direct sunlight.

Common questions about Tryptyr

No, Tryptyr isn't a steroid eye drop. Instead, it's a different kind of medication called a TRPM8 thermoreceptor agonist. Tryptyr works by acting on a protein called TRPM8 thermoreceptor on the eye surface. This helps promote tear production. This is unlike steroid eye drops, which work to lower inflammation related to dry eye.

Tryptyr can start working fairly quickly, but you might not feel the full benefits right away. Most people notice better tear production within about 2 weeks of use. Some have even felt relief as early as the first day. Keep in mind that it usually takes a few weeks of regular use to see the maximum effect. In studies, symptom improvements stayed steady over 3 months of use. Keep using Tryptyr exactly as your prescriber directed, even if you don't feel a big difference right away. If you feel like your symptoms aren't getting better after using the medication for a few weeks, talk to your prescriber.

Keep unopened cartons of Tryptyr in the refrigerator until you're ready to use it. After opening it, you can keep it in the fridge or at room temperature (up to 77ºF). If you choose to keep the carton at room temperature, it's good for up to 30 days. Each carton contains 12 foil pouches, and each pouch has 5 single-use vials. After you open a foil pouch, the vials inside must be used within 7 days (and before the expiration date on the vial).

You can buy Tryptyr at your local pharmacy with a prescription if they have it in stock. It's a good idea to call ahead to check first. You can also check if your insurance offers a mail order program for Tryptyr.

Tryptyr is manufactured by Alcon Laboratories, Inc.

Risks and warnings for Tryptyr (acoltremon)

Tryptyr (acoltremon) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Potential for eye injury and contamination

Risk factors: Touching the vial tip to your eye, eyelid, fingers, or any surface

Tryptyr (acoltremon) comes in small, single‑use vials. Don't let the tip touch your eye or lashes because it can scratch your eye and cause irritation or injury. Also avoid touching the tip with your fingers and letting it touch any other surface. The tip can also pick up germs from your skin or the environment. This can contaminate the medication and raise your risk of an eye infection. These problems are more likely if you rush, have trouble keeping your hand steady, or try to reuse a vial.

Always wash your hands before and after using Tryptyr (acoltremon). Use each vial one time for both eyes, then throw it away. If the tip accidentally touches something, throw the vial away and open a new one.

Watch for signs of eye infection or injury. This can include more eye redness, thick discharge, swelling, severe eye pain, light sensitivity, or vision changes. Call a healthcare professional right away if you notice these.

Must take out contact lenses

Don’t use Tryptyr (acoltremon) while wearing contact lenses. Be sure to take your lenses out before using the eye drop and wait 15 minutes before putting them back in. This timing gives Tryptyr (acoltremon) a chance get absorbed into the eye and lowers irritation. If you still feel burning or stinging or have blurry vision after you put your lenses back in, remove them and talk to an eye care professional.

Tryptyr (acoltremon) dosage

The average cost for 1 carton of 60 vials of 0.003% of Tryptyr (acoltremon) is $851.05 with a free GoodRx coupon. This is 19.62% off the average retail price of $1,058.76.