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Thiothixene

Thiothixene Side Effects

Daisy Chau, PharmDAshley Wong, PharmD
Reviewed by Daisy Chau, PharmD, Ashley Wong, PharmD
Last reviewed on January 21, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Constipation
  • Blurred vision
  • Fainting or lightheadedness
  • Nausea or vomiting
  • Diarrhea
  • Dry mouth or more salivation
  • Changes in appetite
  • Weight gain
  • Very high fever
  • Weakness
  • Sexual side effects
  • Absent or irregular menstrual periods

Thiothixene serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Neuroleptic malignant syndrome (NMS): very high fever, muscle stiffness, confusion, abnormal pulse, changes in blood pressure, fast heartbeat, sweating, changes in heart rhythm
  • Uncontrolled muscle movements (tardive dyskinesia): involuntarily sticking out your tongue, puffing out your cheeks, puckering your mouth, lip smacking, chewing, foot tapping
  • Serious infection (from low blood cell count): fever, weakness, fatigue, sore throat, cough, body aches, chills
  • Seizures

Source: DailyMed

The following Thiothixene side effects have also been reported

Along with their needed effects, thioxanthenes can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. Some of these side effects, including severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures, may be the sign of a condition called neuroleptic malignant syndrome. You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Rare

Convulsions (seizures)

difficulty in breathing

fast heartbeat

high fever

high or low (irregular) blood pressure

increased sweating

loss of bladder control

muscle stiffness (severe)

unusually pale skin

unusual tiredness

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Difficulty in talking or swallowing

inability to move eyes

lip smacking or puckering

loss of balance control

mask-like face

muscle spasms, especially of the neck and back

puffing of cheeks

rapid or worm-like movements of tongue

restlessness or need to keep moving (severe)

shuffling walk

stiffness of arms and legs

trembling and shaking of fingers and hands

twisting movements of body

uncontrolled chewing movements

uncontrolled movements of the arms and legs

Less common

Blurred vision or other eye problems

difficult urination

fainting

skin discoloration

skin rash

Rare

Hot, dry skin or lack of sweating

increased blinking or spasms of eyelid

muscle weakness

sore throat and fever

uncontrolled twisting movements of neck, trunk, arms, or legs

unusual bleeding or bruising

unusual facial expressions or body positions

yellow eyes or skin

Symptoms of overdose

Difficulty in breathing (severe)

dizziness (severe)

drowsiness (severe)

muscle trembling, jerking, stiffness, or uncontrolled movements (severe)

small pupils

unusual excitement

unusual tiredness or weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation

decreased sweating

dizziness, lightheadedness, or fainting

drowsiness (mild)

dryness of mouth

increased appetite and weight

increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin, or severe sunburn)

stuffy nose

Less common

Changes in menstrual period

decreased sexual ability

swelling of breasts (in males and females)

unusual secretion of milk

After you stop taking this medicine your body may need time to adjust, especially if you took this medicine in high doses or for a long time. If you stop taking it too quickly, the following withdrawal effects may occur and should be reported to your doctor:

Dizziness

nausea and vomiting

stomach pain

trembling of fingers and hands

uncontrolled, continuing movements of mouth, tongue, or jaw

Although not all of the side effects listed above have been reported for all thioxanthenes, they have been reported for at least one of them. However, since these medicines are very similar, any of the above side effects may occur with any of them.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.
Ashley Wong, PharmD, is a licensed pharmacist in California. She has over 6 years of experience providing drug information.

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