Type your drug name (like Atorvastatin, Sildenafil, etc)
Pentazocine / Naloxone Coupon - Pentazocine / Naloxone 50mg/0.5mg tablet
Talwin NXPentazocine / Naloxone
PENTAZOCINE; NALOXONE is a pain reliever. It is used to treat moderate to severe pain. It also contains naloxone, which is used to prevent the misuse of this medicine. The lowest GoodRx price for the most common version of pentazocine / naloxone is around $78.90, 69% off the average retail price of $260.17. Compare opioid Agonist/Antagonists.
Prescription Settings
90 tablets
Pentazocine / Naloxone Coupon - Pentazocine / Naloxone 50mg/0.5mg tablet
pentazocine / naloxone(generic)
90 tablets

Talwin NX Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

If you are also taking a narcotic medicine for pain or cough or another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Your mouth may get dry. Chewing sugarless gum or sucking on hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:


Black, tarry stools

chest pain


cough or hoarseness

difficult or troubled breathing


fever with or without chills

general feeling of tiredness or weakness

irregular, fast or slow, or shallow breathing

lower back or side pain

painful or difficult urination

pale or blue lips, fingernails, or skin

shakiness in the legs, arms, hands, or feet

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

trembling or shaking of the hands or feet

unusual bleeding or bruising

unusual tiredness or weakness

Incidence not known

Blistering, peeling, or loosening of the skin

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


decrease in the frequency of urination


difficulty in passing urine (dribbling)

difficulty with swallowing


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


fast, slow, pounding, or irregular heartbeat or pulse

feeling of warmth




joint or muscle pain

loss of bladder control

loss of consciousness


pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid breathing

red skin lesions, often with a purple center

red, irritated eyes

redness of the face, neck, arms, and occasionally, upper chest

skin rash


swelling of the lower legs or arms

swelling of the face

tightness in the chest

total body jerking

upper abdominal or stomach pain

weight gain


Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Seeing, hearing, or feeling things that are not there

seizures (convulsions)

sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Abdominal or stomach distress

hives or welts

redness of the skin

Incidence not known

Blistering, crusting, irritation, itching, or reddening of the skin

confusion about identity, place, and time


constricted, pinpoint, or small pupils (black part of the eye)

continuing ringing or buzzing or other unexplained noise in the ears

cracked, dry, or scaly skin


difficulty in focusing the eyes

disturbed dreams


dry mouth


false or unusual sense of well-being

hearing loss



loss of appetite

mood or mental changes


relaxed and calm feeling

trouble with sleeping

unable to sleep



weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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