Fluocinolone, also known by its brand name, Synalar, is a prescription topical steroid used to treat many inflammatory and itchy skin conditions, such as psoriasis or eczema. It comes as a lower-cost generic cream, ointment, and topical solution. The medication is typically applied to the skin two to four times per day, depending on the condition. Side effects aren't common, but can include skin burning and irritation.
Inflammatory and itchy skin conditions
Fluocinolone is a topical steroid. It blocks certain substances in the body that cause inflammation, which can lead to symptoms like swelling, redness, and itching. This helps treat flare-ups in certain skin conditions.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Body aches or pain
congestion
dryness or soreness of the throat
headache
hoarseness
lightening of normal skin color
lightening of treated areas of dark skin
stuffy or runny nose
tender, swollen glands in the neck
trouble swallowing
unusual tiredness or weakness
voice changes
Less common
accumulation of pus
blistering, crusting, irritation, itching, or reddening of the skin
burning, itching, and pain in hairy areas, or pus at the root of the hair
burning and itching of the skin with pinhead-sized red blisters
change in hearing
cracked, dry, scaly skin
ear drainage
flushing or redness of the skin
darkening of the skin
itching, scaling, severe redness, soreness, or swelling of the skin
itchy, raised, round, smooth, skin-colored bumps found on just one area of the body
ooze thick white fluid
raised, dark red, wart-like spots on skin, especially when used on the face
redness or swelling in the ear
skin irritation
skin rash, encrusted, scaly and oozing
spots on your skin resembling a blister or pimple
swelling
swollen, red, tender area of infection
thickened patches of the skin
vomiting
Incidence not known
Redness and scaling around the mouth
thinning, weakness, or wasting away of the skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Changes in skin color
shiny skin
Incidence not known
increased hair growth on the forehead, back, arms, and legs
reddish purple lines on the arms, face, legs, trunk, or groin
softening of the skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Can treat various inflammatory and itchy skin conditions
Available in different forms (cream, ointment, topical solution)
Available as a lower-cost generic
Needs to be applied two to four times per day
Not meant for long-term use
Young children might be at higher risk for side effects
Apply fluocinolone as a thin layer to the affected area(s) of your skin 2 to 4 times per day, as prescribed.
Avoid applying fluocinolone on cuts or scrapes in the skin. Keep the medication away from your eyes as well.
Wash your hands well after you apply fluocinolone to your skin. This helps prevent the medication from getting in your eyes.
Don't place bandages or dressings over the areas where you've applied fluocinolone unless your prescriber instructed you to. This can cause more medication to get absorbed into your body than intended. It can also raise your risk of side effects, like burning and irritation.
If your prescriber recommended that you cover the area with bandages or dressings after applying fluocinolone, and you notice redness, itching, pain, or swelling, contact them. These could be signs of a skin infection.
Don't apply other topical steroids to the skin while you're using fluocinolone unless your prescriber specifically said it's safe for you. Applying more than one topical steroid can raise your risk for side effects.
Make sure to tell your prescriber if you're pregnant or breastfeeding before you start treatment with fluocinolone. Discuss the risks and benefits of using this medication with them.
Store fluocinolone at room temperature and in a dry place.
Fluocinolone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Applying fluocinolone to large areas of the body | Applying fluocinolone for a long time | Applying more than one topical steroid onto the skin | Covering the medicated area | Applying onto damaged skin | Children
It's possible for your body to absorb too much fluocinolone through the skin in certain situations, like applying the medication to larger areas of skin over longer periods of time and covering the treated area with tight bandages. This can cause changes in your stress hormone levels (e.g., cortisol), affecting many bodily functions. Symptoms can include tiredness, nausea, and muscle aches, which usually go away after stopping the medication, though severe cases may require additional treatment. And very rarely, more serious problems related to having too much medication in the body can include having higher blood sugar levels and, in children, possibly delayed growth. So it's important to apply fluocinolone only as directed by your prescriber.
Risk factors: Applying fluocinolone to the folds of the skin or face
Unless instructed by your prescriber, don't apply fluocinolone to the face. This medication can cause skin thinning and skin damage, even with short-term use. Apply the smallest amount needed for the shortest duration possible.
Fluocinolone comes as a cream, ointment, and topical solution.
The typical dose is to apply a thin layer to the affected area(s) 2 to 4 times daily, depending on the condition that's being treated.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Inflammatory skin conditions - cream and ointment only
Plaque psoriasis - lotion and foam only
Treatment of skin rashes and itchy skin - all topical forms except shampoo
Treatment of moderate to severe scalp psoriasis - foam and shampoo only
Treatment of plaque psoriasis not on the scalp - all topical forms except shampoo
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Alexandraki, K. I., et al. (2018). Adrenal suppression. Endotext.
Glasshouse Pharmaceuticals Limited Canada. (2024). Fluocinolone acetonide solution [package insert]. DailyMed.
Medimetriks Pharmaceuticals, Inc. (2023). Synalar- fluocinolone acetonide ointment [package insert]. DailyMed.
Medimetriks Pharmaceuticals, Inc. (2024). Synalar- fluocinolone acetonide cream [package insert]. DailyMed.
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