Sudafed (pseudoephedrine) is an alpha agonist used to treat nasal congestion and sinus pressure. It works by restricting the blood vessels in the nose and sinuses. Sudafed doesn't require a prescription, but there are restrictions on its purchase and it is only available at the pharmacy counter. Generic pseudoephedrine is available, and Sudafed PE is another over-the-counter alternative with a different active ingredient (phenylephrine) that has no restrictions.

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