The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Less Common Side Effects
- Herpes simplex infection (e.g., cold sores, genital herpes)
- Mouth ulcers or sores
- Swollen hair follicles
- Acne
- Higher triglyceride levels
Sotyktu serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: rash, trouble breathing, feeling faint, swelling of the face or throat
- Serious infection: fever, weakness, chills, trouble breathing, cough, night sweats, diarrhea, stomach pain, burning when you urinate, urinating more or less often
- Severe muscle damage (rhabdomyolysis): dark brown urine, severe muscle weakness or pain, fever, tiredness
- Liver damage: nausea, stomach pain, yellowing of the skin or whites of the eyes
Source: Prescribing information
The following Sotyktu side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Acne
- Pain, redness, or swelling with sores inside the mouth or throat
- Runny or stuffy nose
- Sinus pain or pressure around the face or forehead
- Small, red, pus-filled bumps on skin around hair follicles








