The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Signifor LAR: Your risk for side effects is higher if you haven't used a somatostatin analog before, and if you have Cushing's disease.
- High blood sugar (29-47%)
- Diarrhea (16-39%)
- Fatigue (10-27%)
- Stomach pain (8-23%)
- Nausea (3-21%)
- Headache (3-19%)
- Diarrhea (58-59%)
- Nausea (46-58%)
- High blood sugar (38-43%)
- Gallstones (30%)
- Headache (28-29%)
- Stomach pain (23-25%)
- Fatigue (15-24%)
Less Common Side Effects
- Dizziness
- Inflammation in nose and throat
- Low blood sugar
- Gallstones
- Fatigue
- Joint pain
- Low appetite
- Dizziness
- Low appetite
- Itching
- Anxiety
- Flu infection
- Joint pain
- Low blood sugar
- Injection-site reactions
Signifor serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Dangerously low blood sugar: feeling faint, shaking, sweating, dizziness, fast heartbeat, nervousness, anxious, confused, irritable, feeling very hungry
- Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
- Extremely low cortisol level: weight loss, feeling very weak, feeling tired, vomiting, no appetite
- Heart rhythm problems: Chest pounding, fluttering in the chest, difficulty breathing, chest pain, feeling faint or lightheaded
- Swelling of the gallbladder or pancreas: sudden pain in upper right portion of your stomach area, back pain between your shoulder blades, nausea, vomiting, fever, swelling in the belly, fast heartbeat, difficulty breathing
Source: DailyMed
The following Signifor side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
bloating or swelling of the face, arms, hands, lower legs, or feet
blurred vision
chills
cold sweat
confusion
cool, pale skin
darkening of the skin
decreased urine
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
flushed, dry skin
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
loss of appetite
loss of consciousness
muscle pain or cramps
nightmares
numbness or tingling in the hands, feet, or lips
pounding in the ears
rapid weight gain
recurrent fever
seizures
shakiness
skin rash
slow, fast, or irregular heartbeat
slurred speech
stomach pain or fullness
sweating
tingling of the hands or feet
trouble breathing
unusual tiredness or weakness
unusual weight gain or loss
vomiting
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Back pain
bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
difficulty with moving
feeling of constant movement of self or surroundings
general feeling of discomfort or illness
joint pain
lack or loss of strength
pain in the arms or legs
sensation of spinning
shivering
stuffy or runny nose
swollen joints
trouble sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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