Ser-Ap-Es is part of the Catecholamine Depletors / Arteriolar Vasodilators / Thiazide Diuretic Combinations class and treats Hypertension. Catecholamine Depletors / Arteriolar Vasodilators / Thiazide Diuretic Combinations are used to treat hypertension. This combination of ingredients lowers blood pressure by decreasing heart rate, relaxing blood vessels, and removing excess water and salt from the body. Ser-Ap-Es is only available as a brand name drug.