What are examples of currently available medications that are used in place of Ser-Ap-Es ?

While [reserpine](https://www.goodrx.com/reserpine/what-is) as a single-ingredient medication has also been discontinued, both [hydralazine](https://www.goodrx.com/hydralazine/what-is) and [hydrochlorothiazide (Microzide)](https://www.goodrx.com/hydrochlorothiazide/what-is) are still available today on their own as well as part of a combination of other medications. There are also many [available medications commonly used today for the treatment of high blood pressure](https://www.goodrx.com/conditions/hypertension/high-blood-pressure-medications).

Ser-Ap-Es

Used for Hypertension

Ser-Ap-Es is a combination medication containing hydralazine, hydrochlorothiazide, and reserpine. The medication is used to lower blood pressure. It's no longer available in the United States because it was discontinued.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Daisy Chau, PharmD

Last reviewed on June 27, 2022

What is Ser-Ap-Es ?

What is Ser-Ap-Es used for?

High blood pressure

Drug facts

Common Brands	Ser-Ap-Es(brand no longer available)
Drug Class	Vasodilator / Diuretic / Rauwolfia alkaloid
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Discontinued

Common Brands

Ser-Ap-Es(brand no longer available)

Drug Class

Vasodilator / Diuretic / Rauwolfia alkaloid

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Discontinued

Common questions about Ser-Ap-Es

Ser-Ap-Es is made up of three medications that all lower your blood pressure. Hydralazine is a vasodilator that relaxes blood vessels, causing them to open up (dilate). Hydrochlorothiazide (Microzide) (HCTZ), is a thiazide diuretic (water pill) that works in the kidneys to remove extra water, which lowers blood pressure and gets rid of swelling. Reserpine is a Rauwolfia alkaloid that works by lowering the levels of certain chemicals in your body that can raise your blood pressure.

No, Ser-Ap-Es has been discontinued and is no longer available in the United States. Although it's not exactly clear why Ser-Ap-Es has been discontinued, it's probably because newer medications are available.

While reserpine as a single-ingredient medication has also been discontinued, both hydralazine and hydrochlorothiazide (Microzide) are still available today on their own as well as part of a combination of other medications. There are also many available medications commonly used today for the treatment of high blood pressure.